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KCNJ11
| Symbol: | KCNJ11 | | Name(s): | potassium inwardly-rectifying channel, subfamily J, member 11 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17976307 |
Carriers of the predisposing Kir6.2 E23K K allele showed no increased risk of either type of diabetes mellitus development. |
| 17919178 |
Both mutations reduced the sensitivity of the K(ATP) channel to inhibition by MgATP and enhanced whole-cell K(ATP) currents. In pancreatic beta cells, such an increase in the K(ATP) current would reduce insulin secretion and thereby cause diabetes. |
| 18290324 |
The polymorphism in KCNJ11 is implicated in the persistent hyperglycemia hypolycemia of infancy disorder. |
| 18290324 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17720745 |
the common E23K genetic variant at the KCNJ11 gene locus was significantly associated with cardiovascular function |
| 18162508 |
The association of 6 loci with type 2 diabetes risk in Japanese patients is reported. |
| 17922473 |
Our results report for the first time a positive association of the E23K variant with type 2 diabetes in an Arab population. |
| 11424233 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12196481 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12540637 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Recent Publications on KCNJ11: |  |
PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
BACKGROUND: Recent advance in genetic studies added the confirmed... | 29th October, 2009
| Department of Endocrinology and Metabolism, Shanghai Jiao Tong University
| PLoS One. 2009 Oct 28;4(10):e7643.
DOI Direct Link |
Improved diabetic control during oral sulfonylurea treatment in two children with permanent neonatal diabetes mellitus.
Permanent neonatal diabetes mellitus (PND), defined as diabetes diagnosed... | 29th October, 2009
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| J Pediatr Endocrinol Metab. 2009 Jul;22(7):661-7.
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Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.
OBJECTIVE: A number of studies have found that reduced birth weight is... | 24th October, 2009
| Division of Human Genetics, The Children's Hospital of Philadelphia,
| Diabetes. 2009 Oct;58(10):2414-8. Epub 2009 Jul 10.
DOI Direct Link |
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.
OBJECTIVE: In the pancreatic beta-cell, ATP-sensitive K(+) (K(ATP))... | 24th October, 2009
| Department of Pharmacology, Alberta Diabetes Institute, University of
| Diabetes. 2009 Oct;58(10):2419-24. Epub 2009 Jul 8.
DOI Direct Link |
A Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps.
Objective- At least twenty type 2 diabetes loci have now been identified... | 8th October, 2009
| 1 Department of Molecular Cell Biology, Leiden University Medical Center,
| Diabetes. 2009 Oct 6.
DOI Direct Link |
→View more research publications. |
KCNJ11 results (if any) from reagent suppliers | 
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KIR6.2 (G-14) Antibody sc-11227
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KCNJ11, 3767, 11p15.1, NM_000525 ...
http://www.scbt.com/datasheet-11227-kir6-2-g-14-antibody.htm...
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Complete Solutions for Ion Channels
... inwardly-rectifying channel: subfamily J: member 8, P0874. KCNJ11, NM_000525 , potassium inwardly-rectifying channel: subfamily J: member 11, P4621 ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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Ion Channels in Endocrine Pancreatic Cells and their Role in Diabetes
Kir6.2 (KCNJ11) pore-forming subunits surrounded by four SUR1 (sulphanylurea receptor, of the ABC transporter protein family) auxiliary subunits. ...
http://www.alomone.com/System/UpLoadFiles/DGallery/Docs/panc...
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D9035 Diazoxide
Gria1(50592), Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj8(25472). mouse ... Kcnj1(56379), Kcnj11(16514). Safety. Personal Protective Equipment, dust ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=D903...
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P154 Pinacidil monohydrate solid
0.1 M HCl: 7 mg/mL. H2O: insoluble. Gene Information, rat ... Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj5(29713), Kcnj8(25472). mouse ... Kcnj11(16514)
...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=P154...
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G2539 Glyburide meets USP testing specifications
suitability, meets USP testing specifications. Gene Information, human ... KCNH2 (3757), KCNJ11(3767). rat ... Kcnj1(24521). storage temp. 2-8°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=G253...
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G0639 Glybenclamide ≥99% (HPLC)
solubility, ethanol: 2 mg/mL. DMSO: soluble. H2O: insoluble. Gene Information, human ... KCNH2(3757), KCNJ1(3758), KCNJ11(3767). rat ... Kcnj1(24521) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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