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KCNJ12
| Symbol: | KCNJ12 | | Name(s): | potassium inwardly-rectifying channel, subfamily J, member 12 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FLJ14167, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x, kcnj12x | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12417321 |
Molecular cloning of functional KCNJ12 with an arginine residue at position 285. |
| 16373386 |
In conclusion, the data are consistent with the universal mechanism of rectification in Kir2 channels, but also point to significant, and physiologically important, quantitative differences between Kir2 isoforms. |
| 15958527 |
Kir2.2 and Kir2.1 are primary determinants of endogenous K(+) conductance in HAECs under resting conditions and that Kir2.2 provides the dominant conductance in these cells. |
| 12032359 |
heteromerization contributes to the phenotype of Andersen syndrome |
| 12598232 |
transcripts for Kir2.2 potassium channels are identified in proliferative smooth muscle cells |
| 16258766 |
Results describe the regulation of inwardly rectifying potassium current and its main molecular correlates, Kir2.1, Kir2.2 and Kir2.3 channels, by endothelin-1 in human atrial cardiomyocytes. |
| 12034888 |
glutamate residue at the C terminus regulates activity -- implications for Andersen Disease (inward rectifier potassium channel 2; IRK2) |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | MINT1 | potassium inwardly-rectifying channel, subfamily J, member 12 | - | - | Pubmed |
| HPRD | Synapse associated protein 97 | potassium inwardly-rectifying channel, subfamily J, member 12 | - | - | Pubmed |
| HPRD | Channel associated protein of synapse 110 | potassium inwardly-rectifying channel, subfamily J, member 12 | - | - | Pubmed |
| HPRD | Synapse associated protein 102 | potassium inwardly-rectifying channel, subfamily J, member 12 | - | - | Pubmed |
| HPRD | Synapse associated protein 90 | potassium inwardly-rectifying channel, subfamily J, member 12 | - | - | Pubmed |
| HPRD | Dystrophin | potassium inwardly-rectifying channel, subfamily J, member 12 | - | - | Pubmed |
| HPRD | Dystrobrevin alpha | potassium inwardly-rectifying channel, subfamily J, member 12 | - | - | Pubmed |
| HPRD | Potassium inwardly rectifying channel subfamily J member 12 | lin-7 homolog A | - | - | Pubmed |
| HPRD | potassium inwardly-rectifying channel, subfamily J, member 12 | CASK | - | - | Pubmed |
| HPRD | potassium inwardly-rectifying channel, subfamily J, member 12 | Veli 1 | - | - | Pubmed |
Recent Publications on KCNJ12: |  |
Kir2.x inward rectifier potassium channels are differentially regulated by adrenergic alpha1A receptors.
Inhibition of I(K1) currents by adrenergic alpha(1) receptors has been... | 7th March, 2008
| Department of Cardiology, Medical University Hospital Heidelberg, Im
| J Mol Cell Cardiol. 2008 Jan;44(1):84-94. Epub 2007 Oct 18.
DOI Direct Link |
Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2.
beta(3)-adrenoceptors have recently been shown to induce a complex... | 5th October, 2007
| Department of Cardiology, Medical University Hospital Heidelberg, Im
| Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):311-22. Epub 2007 May
DOI Direct Link |
17p11.2p12 triplication and del(17)q11.2q12 in a severely affected child with dup(17)p11.2p12 syndrome.
Multiple congenital anomalies/mental retardation syndromes due to genomic... | 31st August, 2007
| Department of Human Genetics, Virginia Commonwealth University, Richmond,
| Clin Genet. 2007 Jul;72(1):47-58.
DOI Direct Link |
Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation.
Cardiac hypertrophy is an independent predictor of cardiovascular... | 28th February, 2007
| Department of Medicine, University of Lausanne Medical School, CHUV
| J Mol Cell Cardiol. 2007 Jan;42(1):63-70. Epub 2006 Oct 30.
DOI Direct Link |
Critical pathways in heart function: bis(2-chloroethoxy)methane-induced heart gene transcript change in F344 rats.
Gene transcript changes after exposure to the heart toxin,... | 15th September, 2006
| National Institutes of Environmental Health Sciences, Research Triangle
| Toxicol Pathol. 2006;34(4):348-56.
DOI Direct Link |
→View more research publications. |
KCNJ12 results (if any) from reagent suppliers | 
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Complete Solutions for Ion Channels
KCNJ12, NM_021012, potassium inwardly-rectifying channel: subfamily J: member 12 , P4496. KCNJ4, NM_008427, potassium inwardly-rectifying channel: subfamily ...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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KIR2.2 siRNA (m) sc-146485
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Kcnj12, 16515, 11 B2, P52187 ...
http://www.scbt.com/datasheet-146485-kir2-2-sirna-m.html...
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KIR2.2 (h): 293T Lysate sc-115662
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KCNJ12, 3768, 17p11.2, Q14500 ...
http://www.scbt.com/datasheet-115662-kir2-2-h-293t-lysate.ht...
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KIR2.1 (N-18) Antibody sc-18708
Mouse, Kcnj12, 16515, 11 B2, P52187, 없음. Mouse, Kcnj2, 16518, 11 E2, P35561, 없음. 주문정보. 제품명, 카탈로그 번호, 단위, 가격, 수량, 관심상품 ...
http://www.scbt.com/ko/datasheet-18708-kir2-1-n-18-antibody....
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KIR2.1 (N-18) Antibody sc-18708
マウス, Kcnj12, 16515, 11 B2, P52187, N/A. マウス, Kcnj2, 16518, 11 E2, P35561, N/A. 注文情報. 製品名, カタログ #, Unit, 価格, 数量, ウィッシュリスト ...
http://www.scbt.com/ja/datasheet-18708-kir2-1-n-18-antibody....
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KIR2.1 (N-18) Antibody sc-18708
Ratón, Kcnj12, 16515, 11 B2, P52187, No Aplicable. Ratón, Kcnj2, 16518, 11 E2, P35561, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-18708-kir2-1-n-18-antibody....
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