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KCNMA1
| Symbol: | KCNMA1 | | Name(s): | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | BKTM, DKFZp686K1437, KCa1.1, MGC71881, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, mSLO1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18227273 |
The influence of the intrinsic electrostatic potential on the channel conductance of KCNMA1 was studied experimentally and theoretically by amino acid substitution. |
| 17901123 |
data suggest sensory nerves and BKCa channels play major roles in the EDHF component of reactive hyperaemia and appear to work partly independent of each other |
| 17150299 |
Alternative splicing of this protein may represent a mechanism with which relaxation of corporal tissue may be triggered as a result of a diabetes-related decline in erectile capacity. |
| 17989352 |
Slo1-actin interactions are necessary for normal trafficking of calcium channels to the plasma membrane. |
| 18162557 |
analysis of how the RCK2 domain of the human BKCa channel is a calcium sensor |
| 17521822 |
reports that coexpression of beta2 subunit (KCNMB2) with hSlo can also modulate hSlo surface expression levels in HEK293T cells |
| 17586600 |
Interactions with filamin A stimulate surface expression of KCNMA1 in the absence of direct actin binding. |
| 17468961 |
both the inner and outer domains of the KCNMA1 channel where these two channel functions are localized respond to deformation and that a fixed amount of distortion results in reciprocal changes in protein function. |
| 17483867 |
The activity of BK(Ca) channels present in human cardiac fibroblasts may contribute to the functional activities of heart cells through transfer of electrical signals between these two cell types. |
| 17591990 |
the beta(2) subunit of BK(Ca) channels facilitates channel activation by changing the voltage sensor equilibrium and that the beta(2)-induced inactivation process does not follow a typical N-type mechanism | →View more information from publications. |
Recent Publications on KCNMA1: |  |
Activation of the BK(Ca) channel increases outflow facility and decreases trabecular meshwork cell volume.
PURPOSE: Inhibition of the BK(Ca) channel attenuated the nitric... | 22nd October, 2009
| Department of Pharmacodynamics, University of Florida, 1600 SW Archer
| J Ocul Pharmacol Ther. 2009 Aug;25(4):309-14.
DOI Direct Link |
Intersubunit coupling in the pore of BK channels.
The structural basis underlying the gating of large conductance... | 20th October, 2009
| Key Laboratory of Molecular Biophysics, Huazhong University of Science and
| J Biol Chem. 2009 Aug 28;284(35):23353-63. Epub 2009 Jun 26.
DOI Direct Link |
Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy.
A long-sought goal in structural biology has been the imaging of membrane... | 7th October, 2009
| Department of Cellular and Molecular Physiology, Yale University, 333
| Nature. 2009 Sep 10;461(7261):292-5. Epub 2009 Aug 30.
DOI Direct Link |
The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin.
Large conductance calcium-activated potassium channels (MaxiK) play a... | 6th October, 2009
| University of Rochester School of Medicine and Dentistry, United States;
| J Biol Chem. 2009 Oct 1.
DOI Direct Link |
A Large Conductance (BK) Potassium Channel subtype affects both growth and mineralisation of Human Osteoblasts.
The pharmacology of the large conductance BK channel in human osteoblasts... | 25th September, 2009
| 1Cardiff University.
| Am J Physiol Cell Physiol. 2009 Sep 23.
DOI Direct Link |
→View more research publications. |
KCNMA1 results (if any) from reagent suppliers | 
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Anti-Potassium Channel BKCa (High-conductance Ca2+-activated K+ ...
Maxi-K+, Slo, KCNMA1). Developed in Rabbit, Affinity Isolated Antibody. Product Number P 8357 ... Activated K+ Channel, Maxi-K+, Slo, KCNMA1) is ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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Anti-KCa1.1 (BKCa)
7 Aug 2007 ... (Large conductance Ca2+-activated K+ channel, BKCa, Maxi K+, KCNMA1). Product #: APC-107. Current Lot ##: AN-01, AN-02; AN-03. Host: Rabbit. ...
http://www.alomone.com/System/UpLoadFiles/DGallery/Docs/APC-...
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Anti-Potassium Channel KCa1.1, (BKCa) (1184-1200)(Large ...
Channel); MAXI K+ ; KCNMA1). Developed in Rabbit, Affinity Isolated Antibody. Product Number P 4872. Product Description. Anti-Potassium Channel KCa1.1 ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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MaxiKα siRNA (h) sc-42511
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KCNMA1, 3778, 10q22.3, NM_001014797,
...
http://www.scbt.com/datasheet-42511-maxikalpha-sirna-h.html...
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Complete Solutions for Ion Channels
KCNMA1, NM_002247, potassium large conductance calcium-activated channel: subfamily M: alpha member 1, P8357 · P4872. KCNMB1, NM_004137, potassium large
...
http://www.sigmaaldrich.com/life-science/functional-genomics...
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MaxiKα siRNA (m) sc-42512
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Kcnma1, 16531, 14 A3, Q08460 ...
http://www.scbt.com/datasheet-42512-maxikalpha-sirna-m.html...
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Antibodies to Ion Channels
Anti-Potassium Channel BKCa (High-conductance Ca2+-activated K+ Channel, Maxi-K+ , Slo, KCNMA1), rabbit, P8357. Anti-KV Channel Interacting Protein 2, rabbit ...
http://www.sigmaaldrich.com/life-science/cell-biology/antibo...
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