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ACAT1
| Symbol: | ACAT1 | | Name(s): | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ACAT, MAT, T2, THIL | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15158756 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18000807 |
increase in the in vitro ACAT1 activity in PC-3 prostate cancer cells treated with androgen |
| 17236799 |
E252del is a temperature-sensitive K(m) mutant. |
| 17691824 |
Several residues in one subunit closely interact with the same residues in the other subunit; mutating these res. to Cys does not lead to loss in enzyme activity. Mutating residues F453, A457, or H460 to Cys causes large loss in enzyme activity. |
| 15128923 |
"mild" mutations (A132G, D339-V340insD) retained some residual T2 activity |
| 16935016 |
Cloning and sequencing long range PCR products revealed a 6.4kb deletion. Alu element-mediated unequal homologous recombination between an Alu-Sx in intron 1 and another Alu-Y in intron 4 appears to be responsible for this deletion. |
| 12754704 |
Single base substitutions at the initiator codon produced wild-type T2 polypeptide to various degrees |
| 17371050 |
Crystallographic and kinetic studies were made on mitochondrial acetyl-CoA thiolase: the importance of potassium and chloride ions were noted for its structure and function. |
Recent Publications on ACAT1: |  |
Niacin Improves Renal Lipid Metabolism and Slows Progression in Chronic Kidney Disease.
Background: Mounting evidence point to lipid accumulation in the diseased... | 3rd November, 2009
| Division of Nephrology and Hypertension, University of California, Irvine,
| Biochim Biophys Acta. 2009 Oct 27.
DOI Direct Link |
Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model.
BACKGROUND: Emerging evidence suggests that androgens and the androgen... | 30th October, 2009
| Faculty of Pharmaceutical Sciences, University of British Columbia,
| Prostate. 2009 Oct 28.
DOI Direct Link |
Modulation Peroxisome Proliferators Activated Receptor alpha (PPAR alpha) and Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1) Gene expression by Fatty Acids in Foam cell.
:... | 28th October, 2009
| Department of Medical Biochemistry, Faculty of medicine, Tehran University
| Lipids Health Dis. 2009 Oct 26;8(1):47.
DOI Direct Link |
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation.
The specific role of dietary fat in breast cancer progression is unclear,... | 24th October, 2009
| Cellular Biochemistry Laboratory, Methodist Research Institute, 1800 N.
| Breast Cancer Res Treat. 2009 Oct 23.
DOI Direct Link |
The Physiologic Effects of Caloric Restriction Are Reflected in the in Vivo Adipocyte-Enriched Proteome of Overweight/Obese Subjects.
We have applied our recently designed proteomics apparoach to search for... | 16th October, 2009
| NUTRIM School for Nutrition, Toxicology and Metabolism, Department of
| J Proteome Res. 2009 Oct 27.
DOI Direct Link |
→View more research publications. |
ACAT1 results (if any) from reagent suppliers | 
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