Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18347914 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11754000 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15333596 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15730517 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15896204 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16403292 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17200871 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17490516 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17498266 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17868255 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18074414 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18186800 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17610421 |
8 known KIR2DL4 alleles were observed in individuals involved in bone marrow transplantation; 3 new alleles, KIR2DL4*00203, *00502, *0080104, differering from known alleles at the nucleotide but not the protein sequence level were also identified |
| 11994457 |
The single tyrosine-based inhibitory motif (ITIM)in the cytoplasmic domain of KIR2DL4 efficiently inhibits natural cytotoxicity responses and recruits SHP-2 protein tyrosine phosphatase (but not SHP-1) to the 2DL4 cytoplasmic domain in NK cells. |
| 15853895 |
KIR2DL4 alleles may explain the high frequency of this variation in the population. |
| 16366734 |
KIR2DL4 was constitutively internalized into Rab5-positive compartments in NK cells via dynamin-dependent process. Chemokine secretion induced by KIR2DL4 transfection into 293T cells occurred only with recombinant forms of KIR2DL4 trafficked to endosomes. |
| 15778373 |
an inhibitory element was identified in the KIR2DL4 promoter and an activating element was found in the KIR3DL3 promoter; AML-2 acts as a repressor of expression of both KIR2DL4 and KIR3DL3 in mature NK cells |
| 15778339 |
evidence that FcepsilonRI-gamma (gamma) associates with 2DL4 to promote surface expression and provide signal transducing function. |
| 12616484 |
NK cell receptor, KIR2DL4:HLA-G interaction is not essential for human reproduction. |
| 12794136 |
The promoter for KIR2DL4 is expressed by all natural killer (NK) cell clones and drives reporter gene expression only in NK cells. |
| 17171757 |
New insights are provided into the mechanisms by which genetic polymorphism of the KIR2DL4 gene influences its expression. |
| 12055234 |
KIR2DL4 has the potential for both activating and inhibitory functions. |
| 14700593 |
Specific amplification of the D0 & D2 domains permit PCR discrimination of KIR2DL4 alleles & their frequencies in various cell lines and human populations. |
| 15670976 |
report that ILT2 receptor, ILT3 receptor, ILT4 receptor, and KIR2DL4 receptor expression is up-regulated by HLA-G histocompatibility antigen in antigen-presenting cells, natural killer cells, and T cells |
| 15580659 |
4.5% of the individuals of a Caucasoid population bear a recombinant allele of KIR3DP1, officially designed KIR3DP1*004, that associates tightly with gene duplications of KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 |
| 14500636 |
Appropriate engagement of KIR2DL4 can selectively stimulate NK cells to elicit a strong IFN-gamma response, which has the potential to contribute significant biological benefits, but only in individuals capable of expressing this receptor. |
| 12826375 |
isolated 3 distinct KIR2DL4 allele clones in each individual with multiple copies of KIR3DL/S1; assumption that unequal crossover event occurred between differing KIR haplotypes resulting in the duplication of the 2DL4, 3DS1/3DL1 genes |
| 12902476 |
KIR2DL4 transmembrane exon genotype influences both levels of membrane expression and activation of cytotoxic function. |
| 12559621 |
All genotypes seen included genes for KIR2DL4. |
| 12538663 |
NK clones express both 2DL4 alleles and either one or both alleles of the clonally restricted KIR 3DL1 and 3DL2 genes. |
| 11489965 |
Crosslinking of KIR2DL4 with a mAb induces interferon-gamma production, but not cytotoxicity, by resting NK cells in the absence of cytokines. |
