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KIT


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Symbol:KIT
Name(s):v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Type:protein-coding
Organism:Homo sapiens
Synonyms:C-Kit, CD117, PBT, SCFR
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17726262 The frequency of KIT overexpression in gliomas was assessed and the genetic mechanisms underlying KIT overexpression were investigated.
18270328 Observational study of gene-disease association. (HuGE Navigator)
18212542 CD117 proved to be a very sensitive marker of Atypical fibroxanthoma
17960171 c-KIT but not CSF1R mutations play a role in the leukemogenesis of childhood CBF-AML
17645464 The size of the mucosal mast cell (MC) population in patients with inactive inflammatory bowel disease (IBD) is not altered by disease or by stress, yet MC in IBD are different (fewer c-kit receptors) and respond differently (greater activation).
18259950 Exon 11 mutation of CD-117 is associated with gastrointestinal stromal tumor
18265633 c-kit protein expression may play an important role in neoplasia of pancreatic neoplasms.
18265649 C-kit oncogenic mutations are more likely seen in CD-117-positive GISTs arising in the gastrointestinal tract and have no obvious relationship with biological behavior of GISTs.
18006222 Presence of c-kit gene mutations in testicular germ cell tumours may not be associated with bilateral diseases, at least in Japan.
16015387 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD9v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor--Pubmed
HPRDCD9 antigenKIT--Pubmed
HPRDCD63 antigen isoform Av-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor--Pubmed
HPRDCD63 antigen isoform Av-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor--Pubmed
HPRDCD81 antigenv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor--Pubmed
HPRDCD81 antigenv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor--Pubmed
HPRDclathrin heavy chain 1v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor--Pubmed
HPRDclathrin heavy chain 1v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor--Pubmed
HPRDCRKLv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor--Pubmed
HPRDv-crk sarcoma virus CT10 oncogene homolog-likeKIT--Pubmed

Recent Publications on KIT:

Pubmed Logo
Multiple gastrointestinal stromal tumors in neurofibromatosis type 1: Report of a case.
This report presents a case of multiple gastrointestinal stromal tumors...
3rd November, 2009
Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Surg Today. 2009;39(11):979-83. Epub 2009 Nov 1.
DOI Direct Link
Breviscapine ameliorates cardiac dysfunction and regulates the myocardial Ca(2+)-cycling proteins in streptozotocin-induced diabetic rats.
To investigate the influence of breviscapine on the cardiac structure and...
3rd November, 2009
Key Laboratory of Biotherapy of Zhejiang Province, Department of Acta Diabetol. 2009 Oct 31.
DOI Direct Link
Fatal abdominal sarcomatosis secondary to gastrointestinal stromal tumor with bland histology.
Fatal abdominal sarcomatosis is a rare complication secondary to...
3rd November, 2009
Department of Pathology and Laboratory Medicine, James H. Quillen VA Saudi Med J. 2009 Nov;30(11):1469-72.
Nucleic acid amplification technology for hepatitis B virus, and its role in blood donation screening in blood banks.
OBJECTIVE: To investigate the performance of hepatitis B virus polymerase...
3rd November, 2009
Department of Molecular Pathology, Al-Hada Armed Forces Hospital, Taif, Saudi Med J. 2009 Nov;30(11):1416-21.
Carney triad in an adult with aggressive behavior: the first case in Korea.
Carney triad is a rare syndrome of unknown etiology characterized by...
3rd November, 2009
Department of Pathology, Samsung Medical Center, Sungkyunkwan University Yonsei Med J. 2009 Oct 31;50(5):709-12. Epub 2009 Oct 21.
DOI Direct Link

View more research publications.

Press Releases on KIT:

BioPortfolio Logo
Bayer and Onyx Announce Nexavar Data Presentations at 60th American Association for the Study of Liver Diseases Annual Meeting 29th October, 2009 Onyx Pharmaceuticals, Inc.
-- Late Breaker #9

First-in-men Demonstration of Sorafenib Plus TACE for the Treatment of Advanced Hepatocellular Carcinoma (SOCRATES trial)

    -- 
        
Bayer and Onyx Initiate Phase 3 Trial of Nexavar in Patients With Non-Responsive Thyroid Cancer 23rd October, 2009 Onyx Pharmaceuticals, Inc.

WAYNE, N.J. and EMERYVILLE, Calif., Oct. 23 /PRNewswire-FirstCall/ -- Bayer HealthCare Pharmaceuticals, Inc. and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today

Results Reported for Exploratory Phase 2 Study of Nexavar in Combination With Chemotherapeutic Agent Paclitaxel for Treatment of Advanced Breast Cancer 30th September, 2009 Onyx Pharmaceuticals, Inc.

WAYNE, N.J. and EMERYVILLE, Calif., Sept. 30 /PRNewswire-FirstCall/ -- Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced results

MDOUTLOOK(R) Quick Polls Report on Clinical Integration of Key Oncology Developments Following ASCO 2009 24th June, 2009 The Arcas Group

ATLANTA, June 24 /PRNewswire/ -- MDOUTLOOK(R), the innovative oncology intelligence platform, today announced the results from its Quick Poll research, which was launched immediately following

Bayer and Onyx Initiate Phase 3 Trial of Nexavar in Non-Small Cell Lung Cancer 1st June, 2009 Bayer HealthCare Pharmaceuticals, Inc.

WAYNE, N.J. and EMERYVILLE, Calif., June 1 /PRNewswire-FirstCall/ -- Bayer HealthCare Pharmaceuticals, Inc. and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced that the companies have

BioNews Results for KIT

: RSS Logo
BioPortfolio Logo
SoluLinK Develops More Sensitive Analyte Detection With a Breakthrough All-in-One Conjugation Kit: HRP-Antibod
Freshnews.com:  Oct 13 2009 10:51PM Matching: kit
New generation of forensic DNA kits to provide faster DNA results
News-Medical.Net:  Oct 14 2009 7:43AM Matching: kit
New generation of forensic DNA kits to provide faster recovery of more DNA results
News-Medical.Net:  Oct 14 2009 7:35AM Matching: kit
Applied Biosystems Advances 21st Century Forensics with Innovative DNA Analysis Solutions
Freshnews.com:  Oct 13 2009 10:52PM Matching: kit
Gibson Laboratories Achieves CE Mark Conformity For Tri-Valent Swab
Pharmaceutical Online:  Oct 14 2009 9:29AM Matching: kit
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
An Open Label, Prospective, One Arm, Feasibility, Study for The Use of Halevy Kit for the Treatment of Perianal Fistulas in Patients With Crohn's Disease

Patents:

Patents logo
US Patent No.Title
7598345 Immunostimulatory compositions and methods
7598369 siRNA targeting histamine receptor H1
7598370 siRNA targeting polo-like kinase-1 (PLK-1)
7598373 Process for the production of 2-C-methyl-D-ribonolactone
7598382 Aryl substituted imidazoquinolines

View more patents.

KIT results (if any) from reagent suppliers

Google CSE Logo
c-Kit Antibody / c-Kit Antibodies
The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and, more specifically, is closely related to the platelet derived growth factor ...
http://www.scbt.com/table-c-kit.html...

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APEX™ Antibody Labeling Kits
APEX™ Antibody Labeling Kits utilize a unique solid-phase labeling method that enables an efficient, convenient and reliable method for covalently attaching
...
http://www.invitrogen.com/site/us/en/home/brands/Molecular-P...

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Cellular Localization IF Antibody Sampler Kit #4753
The Cellular Localization IF Antibody Sampler Kit provides an economical means for identification cellular organelles by fluorescence immnuocytochemistry ...
http://www.cellsignal.com/products/4753.html...

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DyLight Antibody Labeling Kits
Fast and efficient kits for labeling antibodies with any one of seven high- performance DyLight Fluors (em/ex from 405-800 nm). Two convenient kit formats
...
http://www.piercenet.com/products/browse.cfm?fldID=294EFD98-...

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Redi-Pro Antibody Biotinylation Kit Redi-Pro&trade Antibody ...
Redi-Pro Antibody Biotinylation Kit provided by ProSci Incorporated,
http://www.prosci-inc.com/shop/catalog1/Redi-Pro-Antibody-Bi...

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mTOR Pathway Antibody Sampler Kit #9964
The mTOR Pathway Antibody Sampler Kit contains reagents to investigate the control of protein translation, cell growth, and proliferation through mTOR ...
http://www.cellsignal.com/products/9964.html...

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Pacific Blue Anti-mouse CD117 C-Kit Antibody Anti-CD117 - BioLegend
Pacific Blue Anti-mouse CD117 C-Kit Antibody Anti-CD117 - CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor ...
http://www.biolegend.com/pacific-blue-anti-mouse-cd117-c-kit...

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