BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

KLK2


Suggest Content
Advertise Here
Gene DB Home
Symbol:KLK2
Name(s):kallikrein-related peptidase 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:KLK2A2, MGC12201, hK2
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17593395 role of kallikrein gene 2 and 3 variant SNPs in the etiology of prostate cancer among men of European ancestry
11130770 Observational study of gene-disease association. (HuGE Navigator)
12805332 Observational study of gene-disease association. (HuGE Navigator)
15643194 Observational study of gene-disease association. (HuGE Navigator)
17085659 Observational study of gene-disease association. (HuGE Navigator)
17257635 Observational study of gene-disease association. (HuGE Navigator)
17593395 Observational study of gene-disease association. (HuGE Navigator)
17657743 %fPSA and hK2 add important predictive value in older men and much closer to diagnosis
12124798 Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3.
16152616 Measurements of free prostate specific antigen and hK2 improve on our ability to counsel patients prior to treatment as to their risk of biochemical recurrence

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-1-antichymotrypsin, precursorkallikrein 2, prostatic isoform 1--Pubmed
HPRDalpha-1-antichymotrypsin, precursorkallikrein 2, prostatic isoform 1--Pubmed
BINDandrogen receptor isoform 1Homo sapiens chromosome 19 genomic contig, reference assemblyAR interacts with p-KLK-2.-Pubmed
HPRDKLK2alpha-2-plasmin inhibitor--Pubmed
HPRDKLK2serine proteinase inhibitor, clade A, member 4--Pubmed
HPRDkallikrein 2, prostatic isoform 1Alpha 2 antiplasmin--Pubmed
HPRDkallikrein 2, prostatic isoform 1Kallistatin--Pubmed
HPRDkallikrein 2, prostatic isoform 1Protease inhibitor 6--Pubmed
HPRDkallikrein 2, prostatic isoform 1serine proteinase inhibitor, clade A, member 5--Pubmed
HPRDkallikrein 2, prostatic isoform 1serine proteinase inhibitor, clade A, member 5--Pubmed

Recent Publications on KLK2:

Pubmed Logo
Emerging Biomarkers for the Diagnosis and Prognosis of Prostate Cancer.
BACKGROUND: Early detection of prostate cancer (CaP), the most prevalent...
18th October, 2008
Department of Laboratory Medicine and Pathobiology, University of Toronto, Clin Chem. 2008 Oct 16.
DOI Direct Link
The time course of expression of genes involved in specific pathways in normal human bronchial epithelial cells following exposure to cigarette smoke.
This study was conducted to determine the time course of gene expression...
14th October, 2008
Department of Physiology and Pharmacology, Wake Forest University School Exp Lung Res. 2008 Oct;34(8):513-30.
DOI Direct Link
Proteomic analysis of conditioned media from the PC3, LNCaP, and 22Rv1 prostate cancer cell lines: discovery and validation of candidate prostate cancer biomarkers.
Early detection of prostate cancer is problematic due to the lack of a...
3rd October, 2008
Department of Laboratory Medicine and Pathobiology, University of Toronto, J Proteome Res. 2008 Aug;7(8):3329-38. Epub 2008 Jun 26.
DOI Direct Link
Development of peptides specifically modulating the activity of KLK2 and KLK3.
The prostate produces several proteases, the most abundant ones being...
27th September, 2008
Department of Clinical Chemistry, Biomedicum Helsinki, University of Biol Chem. 2008 Jun;389(6):633-42.
DOI Direct Link
Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration.
Tissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a...
27th September, 2008
Program for Molecular Neuroscience, Mayo Clinic College of Medicine, Biol Chem. 2008 Jun;389(6):739-45.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Correlation of Urinary Kallikrein With Cytokines, Proteinuria and Renal Function in Chronic Renal Disease Patients
Chronic Kidney Disease

Patents:

Patents logo
US Patent No.Title
7361474 Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer
6197511 Human kallikrein
6184357 Prostate-specific kallikrein
6093796 Recombinant hK2 polypeptide
6043033 Human prostate-associated protease

View more patents.

KLK2 results (if any) from reagent suppliers

Google CSE Logo
KLK2 Antibody (C-term)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/catalog_no/AP6321b...

Thumbshot
KLK2 siRNA (h) sc-41531
Recommended Control Antibody (click catalog # for product information). Product Name, Catalog #, Unit, Price, Qty, Wish List. KLK2 (F-17), sc-20368 ...
http://www.scbt.com/datasheet-41531-klk2-sirna-h.html...

Thumbshot
View Cart
KLK2 Antibody (C-term), AP6321b, 0.1mg, $99.00, $99.00. Shipping, flat fee, $35.00. Tax will be added to the Total after the order is processed. ...
https://www.abgent.com/store/add_to_cart/AP6321b...

Thumbshot
KLK Antibody / KLK Antibodies
KLK2 (R-15) Antibody, sc-20370, goat IgG, internal (r), WB, IF, ELISA, rat. KLK2 (F-17) Antibody, sc-20368, goat IgG, internal (h), WB, IF, ELISA, human ...
http://www.scbt.com/table-klk.html...

Thumbshot
View Cart
KLK2 Antibody (N-term) Blocking Peptide, BP6321a, 0.1mg, $42.00, $42.00. Shipping, flat fee, $35.00. Tax will be added to the Total after the order is
...
https://www.abgent.com/store/add_to_cart/BP6321a...

Thumbshot
Orbigen Inc. - Orbigen Inc.
... and malignant glandular epithelial cells, thus exhibiting an expression pattern similar to that of two other prostatic kallikreins, KLK2 and KLK3. ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

Thumbshot
Discovery
that the KLK2 product,which has trypsin-like. Kallikrein /. Disease ... KLK2. Prostate cancer, breast cancer ... enhancer regions of KLK1,KLK2,KLK3,and ...
http://www.qedbio.com/pdf/newsletters/winter2004_newsletter....

Thumbshot
New Tools: Human Tissue Kallikrein Products - R&D Systems
KLK2, Human glandular Kallikrein 1 (hGK-1), Breast, Prostate. KLK3, Prostate- specific antigen (PSA), Breast, Prostate. KLK4, Kallikrein-like 1 (KLK-L1) ...
http://www.rndsystems.com/cb_detail_objectname_FA04_NTHumanT...

Thumbshot
PEPTIDE NAME: Z-GPR-AMC, Fluorogenic Substrate
but not KLK2. 7-12 . Ex.: 365nm, Em.: 440nm, although the following Ex/Em can also be used:. 355380/450460. This substrate is useful for inhibitor screening
...
http://www.biomol.com/SiteData/docs/productdata/p142.pdf...

Thumbshot
Part 2 3 2 06.qxp
Kallikrein 2 Antibody See KLK2 (Kallikrein 2). Kallikrein 3 Antibody See KLK3 ( Kallikrein 3 / PSA). Kallikrein 4 Antibody See KLK4 (Kallikrein 4) ...
http://www.imgenex.com/dfiles/DownloadN-36.pdf...

Thumbshot

Search Bioportfolio and other Life Science Sites for KLK2
This page has been viewed 107 times
Recent Search Terms used to find this page: kallikrein related peptidase-2 | klk2 recombinant | recombinant kallikrein 13 | .

Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

  Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2008 - BioPortfolio Limited.