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ARF6


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Gene DB Home
Symbol:ARF6
Name(s):ADP-ribosylation factor 6
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp564M0264
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18084281 Results indicate that GEP100 links EGFR signalling to Arf6 activation to induce invasive activities of some breast cancer cells, and hence may contribute to their metastasis and malignancy.
17623778 ARF6 and ELMO, two proteins known to couple ARNO to the cytoskeleton, were required for calcium-sensing receptor -dependent morphological changes and translocated to the plasma membrane ruffles
17719203 These results suggest that the cycling of ARF6 between its GDP-and GTP-bound states coordinates the recruitment of AP-2 and clathrin to activated receptors during the endocytic process.
17628206 FIP3 is a scaffolding protein that, in addition to regulating endosome targeting to the cleavage furrow, also is required for Arf6 recruitment to the midbody during late telophase.
17640372 ARF6 recruits KALRN to the cell membrane facilitating Rac activation.
17157409 Rab 11 and Arf6 function synergistically in the switch from furrowing to abscission, as well as in the terminal stage of abscission.
16669702 A phosphatidylinositol-3-kinase-dependent signal transition defines the sequence of ARF6 activation during phagocytosis.
15897187 ARF6 activation was necessary for extensive actin reorganization at the bacteria invasion sites.
15590645 ADP-ribosylation factor 6 (ARF6) is essential for the endocytosis of a broad variety of G protein coupled receptors
15231847 role of AMAP2 in cellular function of GTP-Arf6

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDadaptor-related protein complex 1 beta 1 subunit isoform aADP-ribosylation factor 6--Pubmed
HPRDadaptor-related protein complex 1 beta 1 subunit isoform aADP-ribosylation factor 6--Pubmed
HPRDADP ribosylation factor 6development- and differentiation-enhancing factor 2--Pubmed
HPRDADP ribosylation factor 6adaptor-related protein complex 3, delta 1 subunit--Pubmed
HPRDADP ribosylation factor 6ADP-ribosylation factor interacting protein 2--Pubmed
HPRDADP ribosylation factor 6pleckstrin homology, Sec7 and coiled/coil domains 2 isoform 1--Pubmed
HPRDADP-ribosylation factor 6Partner of RAC1--Pubmed
HPRDADP-ribosylation factor 6Cytohesin 2--Pubmed
HPRDADP-ribosylation factor 6PYK C terminus associated protein--Pubmed
HPRDADP-ribosylation factor 6Adaptin, delta--Pubmed

Recent Publications on ARF6:

Pubmed Logo
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.
Slit-Roundabout (Robo) signalling has a well-understood role in axon...
27th October, 2009
[1] Department of Oncological Sciences, University of Utah, Salt Lake Nat Cell Biol. 2009 Oct 18.
DOI Direct Link
Regulation of Insulin Secretion by Phosphatidylinositol-4,5-Bisphosphate.
Abstract The role of PIP(2) in pancreatic beta cell function was examined...
23rd October, 2009
Department of Genetic Medicine and Development, University of Geneva Traffic. 2009 Sep 28.
DOI Direct Link
Reversible bleb formation in mast cells stimulated with antigen is Ca2+-calmodulin -dependent and bleb size is regulated by ARF6.
Mast cells stimulated with antigen undergo extensive changes in their...
23rd October, 2009
Biochem J. 2009 Oct 21.
DOI Direct Link
Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathway.
To understand the role of clathrin-mediated endocytosis in the...
22nd October, 2009
J Cell Sci. 2009 Oct 21.
DOI Direct Link
Phenotypic Plasticity of Adventitious Rooting in Arabidopsis Is Controlled by Complex Regulation of AUXIN RESPONSE FACTOR Transcripts and MicroRNA Abundance.
The development of shoot-borne roots, or adventitious roots, is...
13th October, 2009
Umea Plant Science Centre, Department of Forest Genetics and Plant Plant Cell. 2009 Oct 9.
DOI Direct Link

View more research publications.

BioNews Results for ARF6

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Medical News: Insights Into The Molecular Basis Of Tumor Cell Behavior
BioFind:  Nov 7 2009 11:56AM Matching: arf6
Medical News: Insights Into The Molecular Basis Of Tumor Cell Behavior
BioFind:  Nov 7 2009 11:56AM Matching: arf6
Insights Into The Molecular Basis Of Tumor Cell Behavior
Medical News Today:  Nov 7 2009 11:48AM Matching: arf6
Insights Into The Molecular Basis Of Tumor Cell Behavior
MediLexicon:  Nov 7 2009 8:49AM Matching: arf6

Patents:

Patents logo
US Patent No.Title
7192752 Real time electronic cell sensing systems and applications for cell-based assays
7482334 Therapeutic treatment methods
7507811 siRNA targeting KRAS
7511132 Functional and hyperfunctional siRNA directed against Bcl-2
7511190 Polynucleotides and polypeptides in plants

View more patents.

ARF6 results (if any) from reagent suppliers

Google CSE Logo
ARF6 antibody [SPM371] (ab19871) | Abcam
Mouse monoclonal [SPM371] to ARF6. ARF6 (ADP ribosylation factor 6) is a member of the human ARF gene family. These genes encode small guanine nucleotide ...
http://www.abcam.com/ARF6-antibody-SPM371-ab19871.html...

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Arf6 Antibody
structural similarity, with Arf6 as the single class III protein to date. ... membrane-associated Arf6 appears to play several functions ...
http://www.cellsignal.com/pdf/3546.pdf...

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ARF6 Antibody
ARF6. We're sorry, but this particular item (#82313) has been discontinued. Please visit the Pierce Antibodies web site to search for a suitable alternative
...
http://www.piercenet.com/Products/browse.cfm?fldID=F77FC49A-...

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Arf6 Antibody #3546
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide (KLH-coupled) corresponding to residues surrounding Gly165 of human Arf6
...
http://www.cellsignal.com/products/3546.html...

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ARF6 (3A-1) Antibody sc-7971
See how others have used ARF6 (3A-1): sc-7971 antibody and or ARF6 (3A-1) ... Western blot analysis of ARF6 expression in non-transfected: sc-117752 (A) and
...
http://www.scbt.com/datasheet-7971-arf6-3a-1-antibody.html...

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A5230 Monoclonal Anti-ARF6 antibody produced in mouse 2 mg/mL ...
A5230 Monoclonal Anti-ARF6 antibody produced in mouse 2mg/mL, clone ARFAG, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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The Abcam catalog
ARF6 antibodies. ... ARF6 antibody [6ARF01] - BSA and Azide free. WB. Mouse monoclonal ... ARF6 antibody [ARFAG]. ICC, WB, ELISA. Mouse monoclonal ...
http://www.abcam.com/index.html?t=112161&pt=1&c=2249...

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