BioPortfolio - KPNB1 - karyopherin (importin) beta 1

KPNB1

Symbol:

KPNB1

Name(s):

karyopherin (importin) beta 1

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

IMB1, IPOB, Impnb, MGC2155, MGC2156, MGC2157, NTF97

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

18028944

crystal structure of Imp beta (127-876) in complex SPN1 (1-65) at 2.8-A resolution reveals that Imp beta adopts an open conformation, which is unique for a functional Imp beta/cargo complex, and resembles the conformation of the Imp beta/RanGTP complex

17646395

Data show that a novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta1 interactions.

17916694

study found binding interactions with karyopherin-beta1 caused FG domains of nucleoporin Nup153 to collapse into compact molecular conformations; reversible collapse of the FG domains may play an important role in regulating nucleocytoplasmic transport

17596301

SARS-COV ORF6 protein is localized to the endoplasmic reticulum (ER)/Golgi membrane in infected cells, where it binds to and disrupts nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane.

13679510

XCTK2 binding to microtubules inhibited in the presence of importin alpha and beta

15795315

Inhibition by Impbeta results from depletion nuclear RanGTP, and, in support of this mechanism, expression of mRFP-Ran reversed the inhibition.

16552725

These data suggest the importance of receptor endocytosis, endosomal sorting machinery, interaction with importins alpha1/beta1, and exportin CRM1 in EGFR nuclear-cytoplasmic trafficking.

17537211

dengue virus nonstructural protein 5 nuclear localization through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection

15194443

Importin alpha/beta-mediated nuclear import machinery is regulated in a cell cycle-dependent manner through the modulation of interaction modes between importins alpha and beta.

16982803

These results show that maximum nucleocytoplasmic transport velocities can be modulated by at least approximately 10-fold by the importin beta concentration and hence suggest a potential mechanism for regulating the speed of cargo traffic across the NE.

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