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KRT5
| Symbol: | KRT5 | | Name(s): | keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CK5, DDD, EBS2, K5, KRT5A | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18064689 |
Cytokeratin markers (CK5/6 and K903) are useful in differentiating squamous cell carcinoma from adenocarcinoma when malignant mesothelioma is already excluded |
| 18035671 |
Existence of Ck5-positive cells that differentiate to the glandular or myoepithelial breast cell lineage via intermediary cells. |
| 17855059 |
reports 2 novel mutations in keratin 5 in patients with epidermolysis bullosa complex with an unusual genotype-phenotype correlation |
| 17650314 |
CK5/6 and/or EGFR expressing tumor types have a persistently poorer prognosis over the longer term. |
| 16152605 |
loss of p63 or CK5/6 was associated with features of aggressive tumors, and lack of CK5/6 was significantly associated with reduced survival in multivariate analysis |
| 12655565 |
Four novel KRT5 mutations identified two of which were outside of the KRT5 hotspot domains in 9 Epidermolysis bullosa simplex patients. |
| 12466114 |
expression in breast cancer cells was associated with a poor clinical outcome |
| 17229601 |
Missence mutation is a causse of epidermolysis bullosa simplex in a 3-year old boy. |
| 11973334 |
stutter mutation plays an important role in the organization of the keratin intermediate filament network |
| 15618924 |
a useful adjunct marker in distinguishing cutaneous adnexal neoplasms from metastatic lesions | →View more information from publications. |
Recent Publications on KRT5: |  |
BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.
Expression profiling of BRCA1-deficient tumours has identified a pattern... | 3rd November, 2009
| Department of Oncology, Centre for Cancer Research and Cell Biology,
| Breast Cancer Res Treat. 2009 Oct 31.
DOI Direct Link |
A novel mutation (p.Thr198Ser) in the 1A helix of keratin 5 causes the localized variant of epidermolysis bullosa simplex.
A novel missense mutation (p.Thr198Ser) in the 1A helix of keratin 5 (K5)... | 24th October, 2009
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| Exp Dermatol. 2009 Jul;18(7):650-2. Epub 2009 Feb 8.
DOI Direct Link |
Culture of endodermal stem/progenitor cells of the mouse tongue.
The tongue represents a very accessible source of tissue-specific... | 8th October, 2009
| Department of Cell Biology, Duke University Medical Center, Box 3709,
| In Vitro Cell Dev Biol Anim. 2009 Jan-Feb;45(1-2):44-54. Epub 2008 Oct 2.
DOI Direct Link |
A new pathogenic keratin 5 mutation in a Hindoestan family with localized epidermolysis bullosa simplex.
Epidermolysis bullosa simplex is an autosomal dominant inherited skin... | 3rd October, 2009
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| Eur J Dermatol. 2009 Oct 2.
DOI Direct Link |
New common variants affecting susceptibility to basal cell carcinoma.
In a follow-up to our previously reported genome-wide association study of... | 10th September, 2009
| deCODE genetics,
| Nat Genet. 2009 Aug;41(8):909-14. Epub 2009 Jul 5.
DOI Direct Link |
→View more research publications. |
KRT5 results (if any) from reagent suppliers | 
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Antibodies to Cytokeratins
Krt10(16661), Krt13(16663), Krt18(16668), Krt4(16682), Krt5(110308), Krt6a(16687 ), Krt6b(16688), Krt8(16691) human ... KRT13(3858), KRT18(3875), KRT4(3851), ...
https://www.sigmaaldrich.com/etc/controller/controller-page....
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C1801 Monoclonal Anti-Cytokeratin, pan antibody produced in mouse ...
rat ... Krt2-5(369017), Krt2-8(25626). mouse ... KRT1(16678), Krt5(110308), Krt6a(16687), Krt6b(16688), Krt8(16691). shipped in, dry ice. storage temp. ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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Cytokeratin 5/8 (RCK102) Antibody sc-32328
Mouse, Krt5, 110308, 15 F2, Q922U2, N/A. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. Cytokeratin 5/8 (RCK102), sc-32328 ...
http://www.scbt.com/datasheet-32328-cytokeratin-5-8-rck102-a...
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Cytokeratin 5 antibody (ab24647) | Abcam
Defects in KRT5 are a cause of epidermolysis bullosa simplex. Alternative names Cytokeratin 5 antibody (ab24647). Database links ...
http://www.abcam.com/Cytokeratin-5-antibody-ab24647.html...
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Cytokeratin 5 (3E2F1) Antibody sc-81702
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KRT5, 3852, 12q13.13, NM_000424 ...
http://www.scbt.com/datasheet-81702-cytokeratin-5-3e2f1-anti...
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Integrin
ACTG1 (Actin γ2), KRT4 (Keratin 4), LMNB2 (Lamin B2), VCL (Vinculin). ACTN4 (α- Actinin), KRT5 (Keratin 5), MAPRE1 (EB1), VIM (Vimentin) ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...
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Basic Cytokeratin (AE3) Antibody sc-57004
Human, KRT5, 3852, 12q13.13, NM_000424 · P13647 · 179850. Human, KRT6A, 3853, 12q13.13, NM_005554, NM_058242 · P02538 ...
http://www.scbt.com/datasheet-57004-basic-cytokeratin-ae3-an...
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