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KRT8

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Symbol:	KRT8
Name(s):	keratin 8
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	CARD2, CK8, CYK8, K2C8, K8, KO
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
12868678	Observational study of gene-disease association. (HuGE Navigator)
16143128	Observational study of gene-disease association. (HuGE Navigator)
16327287	Observational study of gene-disease association. (HuGE Navigator)
17509943	Observational study of gene-disease association. (HuGE Navigator)
17954264	Invasive ductal carcinomas of the breast align with the KRT8/18 staining phenotypes.
17509943	A novel but rare keratin-8 Arg341-to-Cys is identified in IBD patients.
17039343	KRT8 sequence variants were studied in patients with pancreatitis and pancreatic neoplasms.
14568682	Aberrantly spliced CK8 (AS-CK8) that lacks caspases cleavage site identified in lung cancer cell lines and primary tumors of NSCLC. Suggests that cancer cells expressing AS-CK8 may have resistance to apoptosis and may perturb keratin network formation.
14756564	A 20-residue region (313-332) in the rod domain of K8 specifically recognized by A45-B/B3 monoclonal antibody undergoes a conformational change following interaction with keratin K18 and plays a role in stabilization of the keratin cytoskeleton.
15319370	K8 alters the epidermal cell differentiation, favors the neoplastic transformation of cells, and is ultimately responsible of the invasive behavior of transformed epidermal cells leading of conversion of benign to malignant tumors
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	Annexin I	keratin 8	-	-	Pubmed
HPRD	annexin I	Keratin 8	-	-	Pubmed
HPRD	bystin	keratin 8	-	-	Pubmed
HPRD	bystin	keratin 8	-	-	Pubmed
HPRD	epidermal growth factor receptor oncogene homolog, avian)	keratin 8	-	-	Pubmed
HPRD	epidermal growth factor receptor oncogene homolog, avian)	keratin 8	-	-	Pubmed
HPRD	Heat shock 70kD protein 5	keratin 8	-	-	Pubmed
HPRD	heat shock 70kDa protein 5	Keratin 8	-	-	Pubmed
HPRD	Keratin 8	plakophilin 1	-	-	Pubmed
HPRD	keratin 8	Plakophilin 1	-	-	Pubmed

Recent Publications on KRT8:
On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network. In the current study, we extend our own previous results on the thymocyte...	20th October, 2009	Department of Cell Biology, Complutense University, Madrid, Spain.	Int J Dev Biol. 2009;53(7):971-82. DOI Direct Link
Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries. The purpose of this study was to screen for genes involved in ovarian...	30th September, 2009	Division of Functional Genomics, School of Medicine, Jichi Medical	Int J Oncol. 2009 Nov;35(5):973-6.
Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones. Atypical PKC (PKC iota) is a key organizer of cellular asymmetry....	18th September, 2009	Department of Cell Biology and Anatomy, University of Miami Miller School	J Cell Sci. 2009 Jul 15;122(Pt 14):2491-503. Epub 2009 Jun 23. DOI Direct Link
Breast carcinoma cells in primary tumors and effusions have different gene array profiles. The detection of breast carcinoma cells in effusions is associated with...	15th August, 2009	Department of Pharmacology and Experimental Therapeutics, School of	J Oncol. 2010;2010:969084. Epub 2009 Aug 11. DOI Direct Link
Effect of the microenvironment and embryo density on developmental characteristics and gene expression profile of bovine preimplantative embryos cultured in vitro. The Well of the Well (WOW) system has been developed to culture embryos in...	16th June, 2009	Animal Breeding and Husbandry Group, Insititute of Animal Science,	Reproduction. 2009 Mar;137(3):415-25. Epub 2008 Dec 19. DOI Direct Link
→View more research publications.

Patents:
US Patent No.	Title
7598051	Compositions and methods for the therapy and diagnosis of ovarian cancer
6953663	Polymorphism detection
6936417	Gene expression in bladder tumors
6867283	Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells
6774223	Method of diagnosing, monitoring, staging, imaging and treating colon cancer
→View more patents.

KRT8 results (if any) from reagent suppliers

Antibodies to Cytokeratins KRT8(3856), feline, rabbit, bovine, canine, human, IF (i), IHC (f), WB, pricing .... human ... KRT8(3856), human, bovine, EM, IF (i), IHC (f), WB, pricing ... https://www.sigmaaldrich.com/etc/controller/controller-page....
Cytokeratin 8 (Ks8.7) Antibody sc-101459 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KRT8, 3856, 12q13.13, NM_002273 ... http://www.scbt.com/datasheet-101459-cytokeratin-8-ks8-7-ant...
Anti-Cytokeratin 18 Polyclonal Antibody The PY-10150 immunogen is a KRT8 fusion protein corresponding to residues 391- 483. Cytokeratins are a subfamily of intermediate filament proteins and are ... http://www.bioreagents.com/products/productDetails/productDe...
C1801 Monoclonal Anti-Cytokeratin, pan antibody produced in mouse ... rat ... Krt2-5(369017), Krt2-8(25626). mouse ... KRT1(16678), Krt5(110308), Krt6a(16687), Krt6b(16688), Krt8(16691). shipped in, dry ice. storage temp. ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
Monoclonal Antibody to Cytokeratin 8/18 (Clone 5D3) Principal Names: Keratin 8 Official Gene Symbol: KRT8 Gene ID: 3856 (Human) Gene Map Locus: ... accession no is NP_954657.1 (KRT18), NP_002264.1 (KRT8) ... http://www.imgenex.com/tds/IMG-80125.pdf...
Cytokeratin 8 + 18 + 19 antibody [2A4] (ab41825) \| Abcam Cytokeratins 8, 18 and 19 are encoded by the genes KRT8, ... KRT8/18 mutations may predispose to liver disease, including cryptogenic cirrhosis, in humans. ... http://www.abcam.com/Cytokeratin-8-18-19-antibody-2A4-ab4182...
Cytokeratin 5/8 (RCK102) Antibody sc-32328 Mouse, Krt8, 16691, 15 F3, P11679, N/A. Mouse, Krt5, 110308, 15 F2, Q922U2, N/A. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List ... http://www.scbt.com/datasheet-32328-cytokeratin-5-8-rck102-a...

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KRT8

Gene Information from Publications

Interacting gene products

Recent Publications on KRT8:

Patents:

KRT8 results (if any) from reagent suppliers