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LAIR1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18209062 |
LAIR-2 prevents binding of human LAIR-1 to collagens and LAIR-1 cross-linking in vitro, suggesting that the protein has an immunoregulatory function in vivo. |
| 17764536 |
in cell lines, LAIR-1, which is not expressed on platelets but is present on most hematopoietic cells, inhibits GPVI responses to collagen but not convulxin |
| 12757266 |
NK cells derived from a boy with CAEBV showed decreased cytotoxic function and impaired IFN-gamma secretion. In addition, the NK cells lacked expression of the broadly expressed NK receptor, LAIR-1. |
| 12072189 |
LAIR-1 exerts inhibitory functions on antigen-specific effector T cells |
| 15065762 |
structure and role of LAIR (review) |
| 17330824 |
Regulated expression of LAIR-1 and the subsequent change in the threshold for activation may be a mechanism to modulate inhibition of the immune system. |
| 16754721 |
Collagens are functional ligands for LAIR-1 and directly inhibit immune cell activation in vitro. |
Recent Publications on LAIR1: |  |
Detection of novel leukocyte differentiation antigens on basophils and mast cells by HLDA8 antibodies.
BACKGROUND: Basophils (BA) and mast cells (MC) are important effector... | 11th January, 2007
| Department of Internal Medicine I, Division of Hematology and
| Allergy. 2006 Sep;61(9):1054-62.
DOI Direct Link |
Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene.
Peripheral blood monocytes migrate to and accumulate in hypoxic areas of... | 7th September, 2006
| Laboratory of Molecular Biology, G. Gaslini Institute, Genova, Italy.
| J Immunol. 2006 Aug 1;177(3):1941-55.
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Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells.
BACKGROUND: The cell adhesion molecule integrin alpha 4 beta 7 helps... | 23rd February, 2005
| Department of Medicine, University of California, San Francisco, CA
| BMC Immunol. 2004 Jul 5;5:13.
DOI Direct Link |
[Preparation, characterization and application of monoclonal antibodies to Fc fragment of Ig fusion protein]
AIM: To prepare and characterize mAb to Fc fragment of Ig fusion protein,... | 21st May, 2004
| Deparment of Immunology, Fourth Military Medical University, Xi'an 710032,
| Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003 Mar;19(2):170-1.
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[Cloning, prokaryotic expression of LAIR and identification of their immunological reactivities]
AIM: To clone and express the leukocyte-associated immunoglobulin-like... | 21st May, 2004
| Department of Immunology, Fourth Military Medical University, Xi'an
| Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003 Mar;19(2):118-20.
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