Friday November 27 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

LAMA3


Suggest Content
Advertise Here
Gene DB Home
Symbol:LAMA3
Name(s):laminin, alpha 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:E170, LAMNA, LOCS, lama3a
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17825249 These results suggest that Crk is required for early attachment to laminin, cell motility, and growth of glioblastoma cell line KMG4.
15149852 co-cultures of epithelial cells and fibroblasts were studied to analyse the processing of laminin 5 alpha3, beta3, and gamma2 chains
15695818 the LG4-5 domain synergistically enhances integrin signaling as it is released from the precursor LN5
15044476 Characterization of laminin 5B and NH2-terminal proteolytic fragment of its alpha3B chain
15373767 Premature termination codon mutations in both alleles of LAMB3 or LAMC2 genes were found in nine of the 11 H junctional epidermolysis bullosa patients
12826666 laminin alpha 3 LG4 module may play an important role in tissue remodeling by inducing MMP-1 expression during wound healing
16219677 Suppression of laminin-5 alpha 3-chain expression in human mammary epithelial cells results in loss of reconstituted extracellular matrix-mediated growth control and apoptosis.
12532327 These results suggest that the G3 domain of laminin 5 alpha 3 contains two distinct regions that differently regulate cell adhesion and migration.
15694127 in the NtA-laminin complex, conserved amino acids in the gamma 1 chain are prerequisite for the binding to agrin
12943669 a missense mutation in the adhesion G domain of laminin-5 causes mild junctional epidermolysis bullosa

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBone morphogenic protein 1laminin alpha 3 subunit precursor--Pubmed
HPRDbone morphogenetic protein 1 isoform 3, precursorLaminin alpha 3 subunit--Pubmed
HPRDIntegrin alpha 3laminin alpha 3 subunit precursor--Pubmed
HPRDintegrin alpha 3 isoform b, precursorLaminin alpha 3 subunit--Pubmed
HPRDLaminin alpha 3 subunitlaminin S B3 chain--Pubmed
HPRDLaminin alpha 3 subunitplasminogen activator, tissue type isoform 1 preproprotein--Pubmed
HPRDlaminin alpha 3 subunit precursorLaminin beta 3--Pubmed
HPRDlaminin alpha 3 subunit precursorTissue type plasminogen activator--Pubmed
HPRDlaminin alpha 3 subunit precursorPlasminogen--Pubmed
HPRDlaminin alpha 3 subunit precursorsyndecan 2--Pubmed

Recent Publications on LAMA3:

Pubmed Logo
Enhanced human bone marrow stromal cell affinity for modified poly(L-lactide) surfaces by the upregulation of adhesion molecular genes.
To enhance and regulate cell affinity for poly (L-lactic acid) (PLLA)...
3rd October, 2009
Institute of Health and Biomedical Innovation, Queensland University of Biomaterials. 2009 Dec;30(36):6903-11. Epub 2009 Sep 30.
DOI Direct Link
Identification of a novel family of laminin N-terminal alternate splice isoforms: structural and functional characterization.
The laminins are a family of heterotrimeric basement membrane proteins...
24th September, 2009
Northwestern University, United States; J Biol Chem. 2009 Sep 22.
DOI Direct Link
Muscle genome-wide expression profiling during disease evolution in mdx mice.
Mdx mice show a milder phenotype than Duchenne patients despite bearing an...
29th May, 2009
Laboratori de Neurologia Infantil, Institut de Recerca, Barcelona, Spain. Physiol Genomics. 2009 Apr 10;37(2):119-32. Epub 2009 Feb 17.
DOI Direct Link
Partial deletion of the LAMA3 gene is responsible for hereditary junctional epidermolysis bullosa in the American Saddlebred Horse.
Laminin 5 is a heterotrimeric basement membrane protein integral to the...
13th March, 2009
Department of Veterinary Science, University of Kentucky, Lexington, KY Anim Genet. 2009 Feb;40(1):35-41. Epub 2008 Nov 11.
DOI Direct Link
Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5).
BACKGROUND: Functional inactivation of the tumor suppressor Smad4 in...
19th November, 2008
Department of Internal Medicine, Knappschaftskrankenhaus, IMBL, BMC Cancer. 2008 Jul 29;8:215.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
6120991 Epiligrin, an epithelial ligand for integrins
6143505 Laminin chains: diagnostic and therapeutic use
6335170 Gene expression in bladder tumors
6620615 G-protein coupled receptor--encoding nucleic acids

View more patents.

LAMA3 results (if any) from reagent suppliers

Google CSE Logo
Antibody Products - IgG Polyclonal Antibodies - GenWay
18-202-335949, LAMA3 Related Product Names: - LAMA3; LAMNA - Laminin alpha 3 subunit isoform 1; N/A, IgG Polyclonal E, Source: Goat Reactivity: Human ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=L...

Thumbshot
Laminin α-3 (T-20) Antibody sc-16587
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Lama3, 16774, 18 A1, Q61789 ...
http://www.scbt.com/datasheet-16587-laminin-alpha-3-t-20-ant...

Thumbshot
Laminin α-3 (H-187) Antibody sc-20143
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Human, LAMA3, 3909, 18q11.2, NM_000227, NM_198129 ...
http://www.scbt.com/de/datasheet-20143-laminin-alpha-3-h-187...

Thumbshot
Laminin α-3 (H-187) Antibody sc-20143
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, LAMA3, 3909, 18q11.2, NM_000227, ...
http://www.scbt.com/ja/datasheet-20143-laminin-alpha-3-h-187...

Thumbshot
Laminin α-3 (H-187) Antibody sc-20143
Humano, LAMA3, 3909, 18q11.2, NM_000227, NM_198129 · Q16787 · 600805. camundongo , Lama3, 16774, 18 A1, Q61789, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-20143-laminin-alpha-3-h-187...

Thumbshot

Search Bioportfolio and other Life Science Sites for LAMA3, or search for LAMA3 on BioPortfolio's antibody search engine.
This page has been viewed 409 times
Recent Search Terms used to find this page:
lama3 antibody | glioblastoma laminin 5 | glioblastoma laminin 5 | laminin background | laminin background | laminin 5 alpha 3 | partial deletion of the LAMA3 gene is responsible for hereditary junctional epidermolysis bullosa in horse | LAMA 3 LAMB3 LAMC2 horse | laminin alpha 3 | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.