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LAMA4


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Gene DB Home
Symbol:LAMA4
Name(s):laminin, alpha 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp686D23145, LAMA3, LAMA4*-1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17533363 alpha4 chain Lms have a de-adhesive function and could thus play a role in detachment, migration and invasion of renal carcinoma cells in vivo.
17646580 2 novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene reduce its integrin binding, & cause endothelial cell loss and heart failure.
16824487 This suggests that G(1121-1139) peptide-containing proteins may perform their biological functions by interacting with alphavbeta3 integrin.
12445830 Data report the identification of a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides.
16146715 laminin isoform changes are associated with brain tumor invasion and angiogenesis [review]
14980521 The alpha4 laminin subunit regulates vascular endothelium cell survival.
15915502 Downregulation of laminin alpha4 chain expression inhibits glioma invasion
15086543 laminin alpha4 LG4 module may play an important role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 and/or -4.
12454288 The G domain of laminin alpha4 chain is a specific, high affinity ligand for alphavbeta3 & alpha3beta1 integrin heterodimers. These integrins, with alpha6beta1, cooperatively mediate endothelial cell-alpha4 laminin interaction & blood vessel development.
12393739 Laminins with alpha1, alpha4, and alpha5 chains are compared to determine laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.

View more information from publications.

Recent Publications on LAMA4:

Pubmed Logo
Cytotoxic effect of recombinant Mycobacterium tuberculosis CFP-10/ESAT-6 protein on the crucial pathways of WI-38 cells.
To unravel the cytotoxic effect of the recombinant CFP-10/ESAT-6 protein...
15th September, 2009
Institute of Biomedical Engineering, National Taiwan University, 1, J Biomed Biotechnol. 2009;2009:917084. Epub 2009 Jun 23.
DOI Direct Link
Regulation of radial glial survival by signals from the meninges.
Radial glial cells (RGCs) in the developing cerebral cortex are...
18th July, 2009
The Scripps Research Institute, Department of Cell Biology, Institute for J Neurosci. 2009 Jun 17;29(24):7694-705.
DOI Direct Link
Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.
Specific inhibition of the entry of encephalitogenic T lymphocytes into...
10th July, 2009
Institute for Physiological Chemistry and Pathobiochemistry, Munster Nat Med. 2009 May;15(5):519-27. Epub 2009 Apr 26.
DOI Direct Link
Overexpression of malignancy-associated laminins and laminin receptors by angiotropic human melanoma cells in a chick chorioallantoic membrane model.
Background: As distinct from intravascular/lymphatic dissemination,...
28th May, 2009
Department of Pathology, University of Miami Miller School of Medicine, J Cutan Pathol. 2009 Mar 24.
DOI Direct Link
Gene expression profiles of human liver cells mediated by hepatitis B virus X protein.
AIM: To demonstrate the gene expression profiles mediated by hepatitis B...
25th April, 2009
Department of Cancer Research, Key Laboratory of Molecular Microbiology Acta Pharmacol Sin. 2009 Apr;30(4):424-34.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7611893 Metal-binding therapeutic peptides
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7510835 Methods for identifying risk of breast cancer and treatments thereof
7482123 Biomarkers for prostate cancer metastasis

View more patents.

LAMA4 results (if any) from reagent suppliers

Google CSE Logo
LAMA4 antibodies: Neuroscience > Cell Adhesion Proteins > ECM ...
LAMA4 antibodies. ... LAMA4 antibody. IHC-P, WB, ELISA, ICC/IF. Images. Rabbit polyclonal. Reacts with: Hu, Ms. Terms and conditions · Legal ...
http://www.abcam.com/index.html?t=240251&pt=1&c=771&ei=&mu=r...

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Laminin α-4 siRNA (h) sc-43147
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, LAMA4, 3910, 6q21, NM_002290 ...
http://www.scbt.com/datasheet-43147-laminin-alpha-4-sirna-h....

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All ECM Proteins | Abcam
LAMA4 antibody. WB. Images. Mouse polyclonal. Reacts with: Hu. ab69634 · LAMA4 antibody. IHC-P, WB, ELISA, ICC/IF. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?c=771...

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Laminin α-4 siRNA (m) sc-43148
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Lama4, 16775, 10 B1, P97927 ...
http://www.scbt.com/datasheet-43148-laminin-alpha-4-sirna-m....

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Abcam antibodies and reagents product map
... Hyaluronan synthase 1 antibodies (1) · I Afadin antibodies (3) · KAL1 antibodies (1) · LAMA4 antibodies (2) · Laminin antibodies (19) ...
http://www.abcam.com/index.html?cl=248&pageconfig=productmap...

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Laminin Antibody / Laminin Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. Laminin α-1 (C-20) 抗体, sc-6016, goat IgG, C-terminus (h), WB, IF, ELISA, human
...
http://www.scbt.com/ja/table-laminin.html...

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Laminin α-4 (H-194) Antibody sc-20144
Humano, LAMA4, 3910, 6q21, NM_002290 · Q16363 · 600133. camundongo, Lama4, 16775 , 10 B1, P97927, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-20144-laminin-alpha-4-h-194...

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