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LAMB1


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Gene DB Home
Symbol:LAMB1
Name(s):laminin, beta 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:CLM, MGC142015
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18162078 Real-time PCR showed that ETOH significantly altered the expression of genes involved in cell adhesion. There was an increase in the expression of alpha and beta Laminins 1, beta Integrins 3 and 5, Secreted phosphoprotein1 and Sarcoglycan epsilon.
12743034 Data suggest that laminin-10 (alpha5beta1gamma1) is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect.
15967115 prostate cancer cells expressing high levels of MT1-MMP have increased invasive potential through their ability to degrade and invade Ln-10 barriers
15987446 laminin beta1 chain (a constituent of laminin-8) was typically found in vessel walls of carcinomas and their metastases but not in those of normal breast
16146715 laminin isoform changes are associated with brain tumor invasion and angiogenesis [review]
12615822 mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions.
15706419 alteration of LAMB1 expression is associated with the genesis and development of uterine leiomyoma
11891225 Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways (Laminin 10; separate entry for Laminin 11).

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDacetylcholinesterase isoform E4-E5 precursorLaminin beta 1--Pubmed
HPRDCollagen, type VI, alpha 1laminin, beta 1 precursor--Pubmed
HPRDcollagen, type VI, alpha 1 precursorLaminin beta 1--Pubmed

Recent Publications on LAMB1:

Pubmed Logo
Oral cancer cells with different potential of lymphatic metastasis displayed distinct biologic behaviors and gene expression profiles.
Objective: Oral squamous cell carcinoma (OSCC) often spreads from the...
15th August, 2009
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, J Oral Pathol Med. 2009 Aug 12.
DOI Direct Link
Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease.
The extensive molecular genetic heterogeneity seen with inherited eye...
17th July, 2009
Department of Clinical Neuroscience, Imperial College London, London SW7 Hum Mol Genet. 2008 Dec 15;17(24):3987-4000. Epub 2008 Sep 22.
DOI Direct Link
The C-terminal region of laminin beta chains modulates the integrin binding affinities of laminins.
Laminins are major cell-adhesive proteins in basement membranes that are...
15th May, 2009
Laboratory of Extracellular Matrix Biochemistry, Institute for Protein J Biol Chem. 2009 Mar 20;284(12):7820-31. Epub 2009 Jan 15.
DOI Direct Link
Requirement for Nudel and dynein for assembly of the lamin B spindle matrix.
The small guanosine triphosphatase Ran loaded with GTP (RanGTP) can...
2nd April, 2009
Laboratory of Molecular Cell Biology and Center of Cell Signaling, Nat Cell Biol. 2009 Mar;11(3):247-56. Epub 2009 Feb 8.
DOI Direct Link
Expression of laminin beta1 in hippocampi of patients with intractable epilepsy.
We investigated laminin beta1 expression in the hippocampi of patients...
4th February, 2009
Department of Neurology, The First Affiliated Hospital, Chongqing Medical Neurosci Lett. 2008 Oct 10;443(3):160-4. Epub 2008 Aug 5.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
5389529 Modified lam.beta. signal sequence and processes for producing recombinant neurotrophins
5660982 Laminin chains: diagnostic uses
6099845 Process for the preparation of Rhus verniciflua extract and anti-cancer composition containing same
6143505 Laminin chains: diagnostic and therapeutic use

View more patents.

LAMB1 results (if any) from reagent suppliers

Google CSE Logo
Laminin β-1 (C-19) Antibody sc-6018
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, LAMB1, 3912, 7q31.1, NM_002291 ...
http://www.scbt.com/datasheet-6018-laminin-beta-1-c-19-antib...

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L8271 Monoclonal Anti-Laminin antibody produced in mouse clone LAM ...
LAMA1(284217), LAMA2(3908), LAMB1(3912), LAMB2(3913). shipped in, dry ice. storage temp. −20°C. Safety. WGK Germany, 3. References ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=L827...

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Laminin β-1 siRNA (m) sc-35781
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Lamb1-1, 16777, 12 A2, P02469 ...
http://www.scbt.com/datasheet-35781-laminin-beta-1-sirna-m.h...

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Antibodies to Extracellular Matrix Proteins
LAMA1(284217), LAMA2(3908), LAMB1(3912), LAMB2(3913), pig, human, feline rat, rabbit, snake, goat, guinea pig, mouse, sheep, canine, chicken, frog, carp, ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Many possibilities. One way forward.
INS, IPF1, ISL1, KRT1, LAMA1, LAMB1,. LAMC1, MYF5, MYOD1, NES, NEUROD1,. NPPA, OLIG-2, PAX4, PAX6, PECAM1,. PTF1A, RUNX2, SERPINA1, SOX17, SST, ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/Cell-C...

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