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LAMC1


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Symbol:LAMC1
Name(s):laminin, gamma 1 (formerly LAMB2)
Type:protein-coding
Organism:Homo sapiens
Synonyms:LAMB2, MGC87297
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15370542 Observational study of gene-disease association. (HuGE Navigator)
17554784 gamma1 laminin is selectively overexpressed in reactive astrocytes of the amyotrophic lateral sclerosis spinal cord
15561105 Expression of LAMC1 in glioblastoma is inhibited by indomethacin. Indomethacin inhibits cyclooxygenases and is an NSAID drug.
12743034 Data suggest that laminin-10 (alpha5beta1gamma1) is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect.
15967115 prostate cancer cells expressing high levels of MT1-MMP have increased invasive potential through their ability to degrade and invade Ln-10 barriers
12526023 The neurite outgrowth domain of gamma 1 laminin accumulates heavily in the floor plate region, in the notochord and in GFAP-immunoreactive glial fibers of the embryonic spinal cord.
15159456 Basement membrane formation is inhibited by a nidogen-laminin gamma1-chain fragment in skin-organotypic cultures.
16146715 laminin isoform changes are associated with brain tumor invasion and angiogenesis [review]
17021862 a polymorphism in the promoter of LAMC1 may increase the susceptibility to early-onset pelvic organ prolapse
12615822 mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDLaminin, alpha 5laminin, gamma 1 precursor--Pubmed
HPRDlaminin alpha 5Laminin, gamma 1--Pubmed
HPRDLaminin, gamma 1nidogen--Pubmed
HPRDlaminin, gamma 1 precursorNidogen 1--Pubmed
HPRDlaminin, gamma 1 precursornidogen 2--Pubmed
HPRDlaminin, gamma 1 precursornidogen 2--Pubmed

Recent Publications on LAMC1:

Pubmed Logo
Lack of laminin gamma1 in embryonic stem cell-derived cardiomyocytes causes inhomogeneous electrical spreading despite intact differentiation and function.
Laminins form a large family of extracellular matrix (ECM) proteins, and...
26th June, 2009
Institute of Physiology I, Life and Brain Center, University of Bonn, Stem Cells. 2009 Jan;27(1):88-99.
DOI Direct Link
Rest-mediated regulation of extracellular matrix is crucial for neural development.
Neural development from blastocysts is strictly controlled by intricate...
19th December, 2008
Centre for the Cellular Basis of Behaviour, The James Black Centre, PLoS One. 2008;3(11):e3656. Epub 2008 Nov 6.
DOI Direct Link
Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression.
Vitamin A (retinol [Rol]) and its metabolites are essential for embryonic...
13th November, 2008
Department of Pharmacology, Weill Medical College of Cornell University, Differentiation. 2008 Sep;76(7):760-71. Epub 2008 Jan 3.
DOI Direct Link
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow.
Basement membranes (BMs) consisting of laminins, collagens, and heparan...
29th May, 2008
Department of Genetics and Pathology, Uppsala University, Dag FASEB J. 2008 May;22(5):1530-9. Epub 2007 Dec 11.
DOI Direct Link
Transcription of laminin gamma1 chain gene in rat mesangial cells: constitutive and inducible RNA polymerase II recruitment and chromatin states.
The laminin gamma1 chain, a critical component of the extracellular...
9th May, 2008
Molecular and Cellular Biology Program, University of Washington Medicine Am J Physiol Renal Physiol. 2008 Mar;294(3):F525-33. Epub 2008 Jan 9.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
5660982 Laminin chains: diagnostic uses
5885776 Glaucoma compositions and therapeutic and diagnositic uses therefor
6143505 Laminin chains: diagnostic and therapeutic use
6271026 Glaucoma compositions

View more patents.

LAMC1 results (if any) from reagent suppliers

Google CSE Logo
Laminin γ-1 (H-190) Antibody sc-5584
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, LAMC1, 3915, 1q25.3, NM_002293 ...
http://www.scbt.com/datasheet-5584-laminin-gamma-1-h-190-ant...

Thumbshot
Many possibilities. One way forward.
LAMC1, MYF5, MYOD1, NES, NEUROD1,. NPPA, OLIG-2, PAX4, PAX6, PECAM1,. PTF1A, RUNX2, SERPINA1, SOX17, SST,. SYCP3, SYP, T, TAT, TH, WT1. Controls ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/Cell-C...

Thumbshot
Proteomic Analysis of CHO Cells during Recombinant Protein ...
LAMC1. Mouse. Laminin gamma-1 chain precursor. P02468. Metabolic. Gene Name. Species. Description. Accession. ASPD. Mouse ...
http://www.sigmaaldrich.com/etc/medialib/safc/biosciences/bi...

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