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LAMC2
| Symbol: | LAMC2 | | Name(s): | laminin, gamma 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2, MGC138491, MGC141938 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15370542 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17786338 |
Overexpression of Laminin-5 gamma2 is associated with oral squamous cell carcinomas |
| 17390227 |
findings suggest that mesenchymal cells contribute to the promotion of tumour cell migration as well as vessel formation in oral squamous cell carcinoma by providing and organising promigratory Ln-5 fragments |
| 15149852 |
co-cultures of epithelial cells and fibroblasts were studied to analyse the processing of laminin 5 alpha3, beta3, and gamma2 chains |
| 16870608 |
Ln-5 is an important regulator of ADPKD cell proliferation and cystogenesis; Ln-5 gamma(2) chain and Ln-5-alpha(6)beta(4) integrin interaction both contribute to these phenotypic changes |
| 17314405 |
domain V of the gamma2 chain negatively regulates the integrin beta4 phosphorylation, probably through a syndecan-1-mediated signaling, leading to enhanced cell adhesion and suppressed cell motility |
| 15373767 |
Premature termination codon mutations in both alleles of LAMB3 or LAMC2 genes were found in nine of the 11 H junctional epidermolysis bullosa patients |
| 12643602 |
Laminin-5 gamma2 chain expression may contribute to formation of budding tumor cells at the invasive front, and immunostaining of this adhesion molecule may be useful in identifying high-risk patients for locoregional failure in T1 colorectal carcinomas. |
| 15963983 |
Ln-5 gamma2 chain regulates the secretion of the alpha3 and beta3 subunits. More importantly, suppression of Ln-5 results in a phenotype that is representative of invasive tumor cells |
| 11920553 |
cytoplasmic expression represents high invasive potential of pancreatic ductal adenocarcinoma and is correlated with distant metastasis and poorer prognosis | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | bone morphogenetic protein 1 isoform 3, precursor | laminin, gamma 2 isoform a precursor | - | - | Pubmed |
| HPRD | bone morphogenetic protein 1 isoform 3, precursor | laminin, gamma 2 isoform a precursor | - | - | Pubmed |
| HPRD | Collagen, type VII, alpha 1 | laminin, gamma 2 isoform a precursor | - | - | Pubmed |
| HPRD | alpha 1 type VII collagen precursor | Laminin, gamma 2 | - | - | Pubmed |
| HPRD | fibulin 2 precursor | laminin, gamma 2 isoform a precursor | - | - | Pubmed |
| HPRD | Laminin beta 3 | laminin, gamma 2 isoform a precursor | - | - | Pubmed |
| HPRD | laminin S B3 chain | Laminin, gamma 2 | - | - | Pubmed |
Recent Publications on LAMC2: |  |
Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.
AIM: To clarify the clinicopathological significance of laminin-5 gamma2... | 29th October, 2009
| First Department of Internal Medicine, Sapporo Medical University School
| World J Gastroenterol. 2009 Aug 21;15(31):3865-73.
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Novel laminin 5 gamma 2-chain fragments potentiating the limbal epithelial cell outgrowth on amniotic membrane.
PURPOSE: Matrix metalloproteases (MMPs)-mediated extracellular matrix... | 3rd October, 2009
| Department of Physiology, Chang Gung University, Tao-Yuan, Taiwan.
| Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4631-9. Epub 2009 May 6.
DOI Direct Link |
Involvement of laminin and integrins in adhesion and migration of junctional epithelium cells.
BACKGROUND AND OBJECTIVE: The junctional epithelium attaches to the enamel... | 16th September, 2009
| Department of Periodontics, Tokyo Dental College, Chiba, Japan.
| J Periodontal Res. 2009 Feb;44(1):13-20. Epub 2008 Sep 11.
DOI Direct Link |
Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model.
Epithelial cell migration during wound healing is regulated in part by... | 3rd September, 2009
| Department of Pharmacology & Toxicology, Ernest Mario School of Pharmacy,
| J Biochem Mol Toxicol. 2009 May;23(3):172-84.
DOI Direct Link |
Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma.
Our previous study demonstrated that the pT2 and pT3-4 gallbladder... | 14th August, 2009
| Departments of Surgery, Tokai University School of Medicine, Kanagawa,
| Biomed Res. 2009 Feb;30(1):53-62.
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→View more research publications. |
LAMC2 results (if any) from reagent suppliers | 
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Laminin γ-2 (C-20) Antibody sc-7652
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, LAMC2, 3918, 1q25.3, NM_005562, ...
http://www.scbt.com/datasheet-7652-laminin-gamma-2-c-20-anti...
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Antibody Products - Protein and Antibody Solutions Provider - GenWay
LAMC2; LAMB2T; LAMNB2 - MOUSE ANTI HUMAN KALININ; Laminin subunit gamma-2, IgG Monoclonal IHC-F, Source: Mouse Reactivity: Human ...
http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=K...
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