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LAMP2


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Symbol:LAMP2
Name(s):lysosomal-associated membrane protein 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD107b, LAMPB, LGP110
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17873513 The biopsied muscle specimen stained for LAMP2 and confirmed the diagnosis of vacuolar myopathy with dilated cardiomyopathy.
17899313 Analysis of the lysosome-associated membrane protein-2 (LAMP-2) gene detected a novel mutation, confirming a diagnosis of Danon disease.
15673802 The glycogen-storage cardiomyopathy produced by LAMP2 or PRKAG2 mutations resembles hypertrophic cardiomyopathy but is distinguished by electrophysiological abnormalities
16144992 LAMP2 mutations may account for significant proportion of cases of hypertrophic cardiomyopathy children, especially when skeletal myopathy and/or Wolff-Parkinson-White syndrome is present. Danon disease may be underrecognized in pediatric cardiology.
15894275 role for the lysosomal Lamp-2a-hsc70 complex in promoting immunological recognition and antigen presentation
16570122 Novel evidence for differential expression of HBGA and LAMPs in proliferative and involutive phases of immunohistochemistry is presented.
14561493 This studu showed decreased LAMP2 expression in the sketal muscle in female patient with Danon disease.
12144129 review of structure, function, cell and tissue distribution, intracellular trafficking
17048695 LAMP-1 and LAMP-2 may have roles in accidental involution of the thymic gland
17296900 Our report further expands the phenotype of Danon disease by describing retinopathy in 3 cases. A thorough clinical examination, including ophthalmic investigation, is needed in all cases of Danon disease.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDlysosomal-associated membrane protein 2 isoform A precursoralpha-synuclein isoform NACP140alpha-synuclein interacts with lamp2a. This interaction was modeled on a demonstrated interaction between human alpha-synuclein and rat lamp2a.-Pubmed

Recent Publications on LAMP2:

Pubmed Logo
The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase.
Pompe disease is a lysosomal storage disorder (LSD) caused by mutations in...
29th October, 2009
Amicus Therapeutics Inc., Cranbury, New Jersey. Hum Mutat. 2009 Sep 4.
DOI Direct Link
Valosin containing protein associated inclusion body myopathy: abnormal vacuolization, autophagy and cell fusion in myoblasts.
Inclusion body myopathy associated with Paget's disease and frontotemporal...
16th October, 2009
Department of Pediatrics, Division of Genetics and Metabolism, University Neuromuscul Disord. 2009 Nov;19(11):766-72. Epub 2009 Oct 13.
DOI Direct Link
Molecular analysis of PRKAG2, LAMP2, and NKX2-5 genes in a cohort of 125 patients with accessory atrioventricular connection.
Danon disease is an X-linked disorder resulting from mutations in the...
24th September, 2009
Am J Med Genet A. 2009 Jul;149A(7):1574-7.
DOI Direct Link
Intracellular fate of Francisella tularensis within arthropod-derived cells.
Since transmission of Francisella tularensis into the mammalian host...
15th August, 2009
Department of Microbiology and Immunology, University of Louisville, Environ Microbiol. 2009 Jun;11(6):1473-81. Epub 2009 Feb 10.
DOI Direct Link
ANCA-small vessel vasculitides: what have we (not yet) learned from animal models?
Anti-neutrophil cytoplasmic autoantibodies (ANCA) with a specificity for...
12th August, 2009
Department of Pathology and Medical Biology, University Medical Center APMIS Suppl. 2009 Jun;(127):21-6.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
5111114 Fluorescent lamp light ballast system
6476567 Control gear for fluorescent lamps
6504315 Lamp system with electronic ballast
6559606 Lamp driving topology
6706867 DNA array sequence selection

View more patents.

LAMP2 results (if any) from reagent suppliers

Google CSE Logo
LAMP2 antibody [GL2A7] - Lysosome Marker (ab13524) | Abcam
Rat monoclonal [GL2A7] to LAMP2 - Lysosome Marker. Lysosomes are membrane bound vacuoles which play a critical role in cellular metabolism.
http://www.abcam.com/LAMP2-antibody-GL2A7-Lysosome-Marker-ab...

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LAMP-2 Antibody
Rabbit polyclonal LAMP-2 antibody was raised against a 17 amino acid peptide from near the ... LAMP-2 antibody is supplied as immunoaffinity purified IgG in
...
http://www.prosci-inc.com/shop/pdf/3627.pdf...

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LAMP-2 (ABL-93) Antibody sc-20004
See how others have used LAMP-2 (ABL-93): sc-20004 antibody and or LAMP-2 ... LAMP-2 (ABL-93) FITC: sc-20004 FITC. FCM analysis of mouse peripheral blood ...
http://www.scbt.com/datasheet-20004-lamp-2-abl-93-antibody.h...

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The Abcam catalog
LAMP2 antibodies. ... LAMP2 antibody [ABL-93] - Lysosome Marker. Flow Cyt, IP, IHC-Fr ... LAMP2 antibody [M3/84] (Biotin). Flow Cyt. Rat monoclonal ...
http://www.abcam.com/index.html?t=10909&pt=1&c=615...

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LAMP Antibody / LAMP Antibodies
LAMP-2 (4E152) Antibody, sc-71491, rat IgG, FL (m), IP, IF, mouse ... LAMP-2 ( ABL-93) Antibody, sc-20004, rat IgG2a, FL (m), WB, IP, IF, FCM, mouse ...
http://www.scbt.com/table-lamp.html...

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Anti-LAMP2 Polyclonal Antibody
Polyclonal Antibody against LAMP2 for use in Immunofluorescence, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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LAMP-2 (H4B4) Antibody sc-18822
See how others have used LAMP-2 (H4B4): sc-18822 antibody and or LAMP-2 (H4B4) antibody ... LAMP-2 siRNA (h): sc-29390. Immunofluorescence staining of ...
http://www.scbt.com/datasheet-18822-lamp-2-h4b4-antibody.htm...

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