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E(z)


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Symbol:E(z)
Name(s):Enhancer of zeste
Type:protein-coding
Organism:Drosophila melanogaster
Synonyms:CG6502, E(z)1, EZ, E[z], Su(z)301, l(3)1902, l(3)67Fa, l(3)B12, l(3)SG17, l(3)ds12, pco, pco/E(z)
Links: Pubmed, Entrez Gene, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17762866 A Pcl-PSC2 complex is the histone methyltransferase that generates the high levels of histone3-lysine27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state.
15776017 The nucleosome-binding subunits Su(z)12 and Nurf55 anchor the E(z) enzyme on chromatin substrates, an essential process in maintaining HOX gene silencing during development.
12533794 ESC and E(Z) are present in multiple distinct complexes that undergo dynamic changes during development
12408863 Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
12408864 We purified an ESC-E(Z) complex from Drosophila embryos and found four major subunits: ESC, E(Z), NURF-55, and the PcG repressor, SU(Z)12. A recombinant complex reconstituted from these four subunits methylates lysine-27 of histone H3.
17210640 one of the roles of ESC (and ESCL and EED) in Polycomb repressive complex 2 complexes is to enable E(Z) to utilize histone H3 as a substrate by physically linking enzyme and substrate

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDextra sexcombs CG14941-PA [Drosophila melanogaster].Enhancer of zeste CG6502-PA [Drosophila melanogaster].E(z) interacts with Esc.-Pubmed
BINDEnhancer of zeste CG6502-PA [Drosophila melanogaster].corto CG2530-PA [Drosophila melanogaster].Corto interacts with E(Z).-Pubmed
BINDEnhancer of zeste CG6502-PA [Drosophila melanogaster].Bicoid interacting protein 1 CG6046-PA [Drosophila melanogaster].E(z) interacts with dSap18.-Pubmed
BINDEnhancer of zeste CG6502-PA [Drosophila melanogaster].pleiohomeotic CG17743-PA, isoform A [Drosophila melanogaster].Pho interacts with E(z).-Pubmed
BINDEnhancer of zeste CG6502-PA [Drosophila melanogaster].His3:CG31613 CG31613-PA [Drosophila melanogaster].E(Z) methylates histone H3.-Pubmed
BINDEnhancer of zeste CG6502-PA [Drosophila melanogaster].Drosophila melanogaster bithorax complex, complete sequence.E(z) interacts with Ubx locus.-Pubmed

E(z) results (if any) from reagent suppliers

Google CSE Logo
Baculo-EZ Expression Ready Clones
Category: Baculo-EZ Expression Ready Clones. Search Result ... Carboxypeptidase E delta-23 (Cpe), BVC-10057, $395.00. Carboxypeptidase X1 (Cpxm1), BVC-10054 ...
http://www.orbigen.com/dictionary/cat1068.htm...

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GST (Z-5) Antibody sc-459
... IP, IF, FCM and ELISA of recombinant GST fusion proteins expressed in E. coli; ... See how others have used GST (Z-5): sc-459 antibody and or GST (Z-5)
...
http://www.scbt.com/product.php?datasheet=459...

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Cayman Chemical | E-64 | Description (CAS 66701-25-5)
E-64 is a natural, potent and irreversible inhibitor of cysteine proteases. 1 Its IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1,
...
http://www.caymanchem.com/app/template/Product.vm/catalog/10...

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Biocare Medical Antibodies - Z
Home > Products > Antibodies. BIOCARE MEDICAL ANTIBODIES. Search Biocare Medical Antibodies By Letter A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
http://www.biocare.net/antibodies.php...

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Cayman Chemical | New Products
EZH1 is a human homolog of the Drosophila gene Enhancer of zeste E(z), a member of the polycomb group of transcriptional repressors. ...
http://www.caymanchem.com/app/template/NewProducts.vm/a/z...

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A to Z Books and Software Titles
Message: Product Catalog > Labware > Books and Software > A to Z Books and Software Titles ... A - (125) · B - (75) · C - (193) · D - (68) · E - (67) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Browse By Molecule < Z > - R&D Systems
Browse By Molecule. Select a Letter: 0-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z ...
http://www.rndsystems.com/molecule_letter.aspx?l=Z...

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