Friday November 27 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

LASP1


Suggest Content
Advertise Here
Gene DB Home
Symbol:LASP1
Name(s):LIM and SH3 protein 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:Lasp-1, MLN50
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17376794 Observational study of gene-disease association. (HuGE Navigator)
17956604 LASP-1 may have roles in progression of human breast carcinoma
15004028 LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions
12571245 phosphorylation of LASP by cGK and cAK may be involved in cytoskeletal organization and cell motility
16430883 LASP-1 has an essential role in tumor cell growth and migration, possibly by influencing the localization of zyxin.
15465019 Data suggest that there are no functional differences between human and mouse LASP-1.
9688835 In rabbits, lasp-1 phosphorylation is increased by histamine H2 receptor activation and elevation of intracellular cAMP
12432067 In rabbits, lasp-1 localizes to sites of dynamic actin assembly, identifies sites that are phosphorylated by protein kinase A in vivo, and shows that the phosphorylation of these sites decreases F-actin-binding to lasp-1.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActin alpha, cardiac muscleLASP1 protein--Pubmed
HPRDcardiac muscle alpha actin 1 proproteinLASP1--Pubmed

Recent Publications on LASP1:

Pubmed Logo
Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.
The mouse mutant wavy tail Tg(Col1a1-lacZ)304ng was created through...
20th October, 2009
Department of Medical Genetics, Molecular and Clinical Pharmacology, Int J Dev Biol. 2009;53(7):983-91.
DOI Direct Link
Redefining the p53 response element.
The tumor suppressor p53 is a master transcriptional regulator that...
29th September, 2009
Laboratory of Immunogenetics, Singapore Immunology Network, A*STAR, 8A Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14373-8. Epub 2009 Jul 13.
DOI Direct Link
Genomic markers for ovarian cancer at chromosomes 1, 8 and 17 revealed by array CGH analysis.
AIMS AND BACKGROUND: The literature data show that the most frequently...
11th September, 2009
Department of Medical Genetics, Medical University, Sofia, Bulgaria. Tumori. 2009 May-Jun;95(3):357-66.
LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma.
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the leading...
30th July, 2009
Laboratory of Immunogenetics and Viral Host-Pathogen Genomics, Singapore J Hepatol. 2009 Mar;50(3):528-37. Epub 2008 Dec 25.
DOI Direct Link
Lasp1 gene disruption is linked to enhanced cell migration and tumor formation.
Lasp1 is an actin-binding, signaling pathway-regulated phosphoprotein that...
18th June, 2009
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Physiol Genomics. 2009 Aug 7;38(3):372-85. Epub 2009 Jun 16.
DOI Direct Link

View more research publications.

BioNews Results for LASP1

: RSS Logo
BioPortfolio Logo
Anti-cancer gene cracked
Asiaone:  Oct 16 2009 1:10AM Matching: lasp1

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
6706867 DNA array sequence selection
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7235358 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

LASP1 results (if any) from reagent suppliers

Google CSE Logo
LASP-1 (KK-M25) Antibody sc-134379
mouse monoclonal IgG2a, 100µg/ml; recommended for detection of LASP-1 of ... Western blot analysis of LASP-1 expression in human LASP-1 transfected (A) and
...
http://www.scbt.com/datasheet-134379-lasp-1-kk-m25-antibody....

Thumbshot
LASP1 proteins and peptides: Signal Transduction > Cytoskeleton ...
LASP1 proteins and peptides. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab22798 · LASP1 peptide (2-14) ...
http://www.abcam.com/index.html?t=8244&pt=2&c=815&ei=&mu=ra...

Thumbshot
LASP Antibody / LASP Antibodies
LASP-1 (KK-M25) Antibody, sc-134379, mouse IgG2a, N/A, WB, IP, ELISA, human. LASP-1 (Q-18) Antibody, sc-103594, goat IgG, Internal (h), WB, IF, ELISA, m, r,
...
http://www.scbt.com/table-lasp.html...

Thumbshot
Abgent - Cell and Structure Antibodies - Cell_structure
AT2669a, LAMA5 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AT2673a, LASP1 monoclonal antibody (M05), ELISA,WB-Tr, H. AP7035c, LATS2 Antibody (Center) ...
http://www.abgent.com/products/category/cell_function/cell_s...

Thumbshot
LASP-1 siRNA (h) sc-105607
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: LASP-1 (h)-PR: sc-105607-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-105607-lasp-1-sirna-h.html...

Thumbshot
Abcam antibodies and reagents product map
... KLHL20 antibodies (1) · KLHL4 antibodies (2) · Kaptin antibodies (3) · Kettin antibodies (1) · LASP1 antibodies (3) · LASP1 proteins and peptides (1)
...
http://www.abcam.com/index.html?c=2105...

Thumbshot
Peptides | Abcam
LASP1 peptide (2-14) · ab45595 · LAT peptide (251-262) · ab5720 · LAT peptide - phospho Y191 (phospho and non-phospho pair) ...
http://www.abcam.com/index.html?pageconfig=catalog_proteins&...

Thumbshot

Search Bioportfolio and other Life Science Sites for LASP1, or search for LASP1 on BioPortfolio's antibody search engine.
This page has been viewed 117 times
Recent Search Terms used to find this page:
Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion pdf | MACF-1 abcam | LASP1 ANTIBODIS | dynamin AND lasp1 | lasp1 autism | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.