Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18083100 |
all Argonautes elevate mature miRNA expression posttranscriptionally, independent of RNase activity. we identify a role for (Ago2) in cleaving the pre-miRNA to an additional processing intermediate, termed Ago2-cleaved precursor miRNA |
| 17662943 |
The two members of the Drosophila Ago subclade of Argonaute proteins are functionally specialized, but specific small RNA classes are not restricted to associate with Ago1 or Ago2. |
| 14615801 |
three-dimensional nuclear magnetic resonance structure of the Drosophila melanogaster Ago2 PAZ domain |
| 15987811 |
Depletion of AGO2, the essentiual factor for siRNA-directed RNAi, resulted in EFGP mRNA stabilization with concomitant shortening of the EFGP mRNA poly(A)tail. |
| 17079687 |
Argonaute 2 is essential for antiviral defense in adult Drosophila melanogaster. |
| 15156196 |
describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides |
| 16024657 |
nuclear division is asynchronous in mutant ago-2 embryos and there are defects in chromosome condensation, nuclear kinesis, and assembly of spindle apparatus |
| 12368261 |
have isolated a dFMR1-associated complex that includes two ribosomal proteins, L5 and L11, along with 5S RNA. The dFMR1 complex also contains Argonaute2 (AGO2) and a Drosophila homolog of p68 RNA helicase (Dmp68) |
| 14625589 |
Crystal structure of the PAZ domain |
| 15452342 |
found homology between the PIWI domain of Ago-2 and endonuclease V and identified potential active-site amino acid residues within the PIWI domain of Ago-2 |
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