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LHCGR


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Symbol:LHCGR
Name(s):luteinizing hormone/choriogonadotropin receptor
Type:protein-coding
Organism:Homo sapiens
Synonyms:LCGR, LGR2, LHR, hLHR
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18300940 Observational study of gene-disease association. (HuGE Navigator)
12679452 Observational study of gene-disease association. (HuGE Navigator)
17074323 Observational study of gene-disease association. (HuGE Navigator)
17692113 Observational study of gene-disease association. (HuGE Navigator)
17709176 Observational study of gene-disease association. (HuGE Navigator)
17609213 study shows FSHR constitutively activating mutants (CAMs) not as active as LHR CAMs with comparable mutation; all FSHR CAMs showed strong promiscuous activation by high concentration of other glycoprotein hormone receptors; LHR CAMs showed little or none
17709176 Although functional changes of the LHR 291Ser candidate allele were observed, no associations with breast cancer were found, while the LHR 312Asn allele can be regarded as a weak breast cancer risk allele.
17548147 In Ishikawa cells LH/hCG does not utilize its conventional receptor.
12270268 LH receptor gene expresses in normal endometrium at very low levels, and at increased levels in endometrial cancerous tissues compared with surrounding microscopically normal tissues
12972613 The LHR gene promoter is repressed by cross talk among the transcription factors EAR3, SP1 and TFIIB.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDChorionic gonadotropin, alpha chainluteinizing hormone/choriogonadotropin receptor precursor--Pubmed
HPRDglycoprotein hormones, alpha polypeptide precursorLuteinizing hormone/choriogonadotropin receptor--Pubmed
HPRDChorionic gonoadotropin, beta chainluteinizing hormone/choriogonadotropin receptor precursor--Pubmed
HPRDchorionic gonadotropin beta 3 subunit precursorLuteinizing hormone/choriogonadotropin receptor--Pubmed
HPRDGNAI2luteinizing hormone/choriogonadotropin receptor precursor--Pubmed
HPRDguanine nucleotide binding protein, alpha inhibiting activity polypeptide 2Luteinizing hormone/choriogonadotropin receptor--Pubmed
HPRDGuanine nucleotide binding protein G(S), alpha subunitluteinizing hormone/choriogonadotropin receptor precursor--Pubmed
HPRDguanine nucleotide binding protein, alpha stimulating activity polypeptide 1 isoform cLuteinizing hormone/choriogonadotropin receptor--Pubmed
HPRDLHBluteinizing hormone/choriogonadotropin receptor precursor--Pubmed
HPRDluteinizing hormone beta subunit precursorLuteinizing hormone/choriogonadotropin receptor--Pubmed

Recent Publications on LHCGR:

Pubmed Logo
Maternal Smoking and Developmental Changes in Luteinizing Hormone (LH) and the LH Receptor in the Fetal Testis.
Context: The LH receptor (LHCGR) drives fetal testosterone secretion,...
20th October, 2009
Divisions of Applied Medicine (P.A.F.) and Applied Health Sciences (S.B.), J Clin Endocrinol Metab. 2009 Oct 16.
DOI Direct Link
Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS).
Genes involved in sex hormone pathways are candidates for influencing bone...
29th August, 2009
ARC Epidemiology Unit, The University of Manchester, Manchester, United J Bone Miner Res. 2009 Feb;24(2):314-23.
DOI Direct Link
Case Report: Adrenal LH/hCG Receptor Overexpression and Gene Amplification Causing Pregnancy-Induced Cushing's Syndrome.
Transient pregnancy-induced Cushing's syndrome (CS) is extremely rare,...
26th August, 2009
Department of Pathology, University Health Network, 200 Elizabeth Street, Endocr Pathol. 2009 Aug 25.
DOI Direct Link
Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice.
Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase (RTK). We...
15th August, 2009
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Mol Reprod Dev. 2009 Aug 13.
DOI Direct Link
Expression profiles of the glucose-dependent insulinotropic peptide receptor and LHCGR in sporadic adrenocortical tumors.
Glucose-dependent insulinotropic peptide receptor (GIPR) and LHCGR are...
7th August, 2009
Laboratorio de Hormonios e Genetica Molecular LIM/42, Divisao de J Endocrinol. 2009 Feb;200(2):167-75. Epub 2008 Oct 29.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7291461 Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6936417 Gene expression in bladder tumors

View more patents.

LHCGR results (if any) from reagent suppliers

Google CSE Logo
Antibodies to Pituitary Hormones
L6792, Anti-Luteinizing Hormone/Choriogonadotropin Receptor antibody produced in rabbit, (polyclonal), affinity isolated antibody, human ... LHCGR(3973) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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LHR (K-15) Antibody sc-26341
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, LHCGR, 3973, 2p16.3, NM_000233 ...
http://www.scbt.com/datasheet-26341-lhr-k-15-antibody.html...

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Jab1 antibody, Jab1 [6C3.38] Antibody, Mouse Monoclonal Antibody
Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of
...
http://www.genwaybio.com/product_info.php?products_id=193297...

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LHR (M-17) Antibody sc-26343
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Mouse, Lhcgr, 16867, 17 E4, P30730 ...
http://www.scbt.com/datasheet-26343-lhr-m-17-antibody.html...

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ABS 001-07-02 to MA1-19150
LHCGR · GB-30071, Hu, ELISA, $375.87. beta-1 Adrenergic Receptor · GB-30072, Hu, ELISA, $375.87. beta-2 Adrenergic Surface Receptor · GB-30073, Hu, ELISA ...
http://www.bioreagents.com/products/productLists/catNumProdu...

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