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LIG3


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Gene DB Home
Symbol:LIG3
Name(s):ligase III, DNA, ATP-dependent
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16492928 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
16609022 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17108146 Observational study of gene-disease association. (HuGE Navigator)
17203305 Observational study of gene-disease association. (HuGE Navigator)
15205355 Observational study of gene-disease association. (HuGE Navigator)
16195237 Observational study of gene-disease association. (HuGE Navigator)
17492771 Results describe the activity requirements for DNA ligases III and IV in the pathways of non-homologous DNA end joining.
11994275 calpain-mediated proteolysis of DNA ligase III plays an essential role in DNA damage-induced cell death in human cells
15653642 In response to DNA damage, DNA ligase IIIalpha translocate from centrosomes to chromosomes.
17643379 key role for XRCC1-DNA ligase IIIalpha in maintenance of genomic integrity by nucleotide excision repair in both dividing and nondividing cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDligase III, DNA, ATP-dependent isoform betatyrosyl-DNA phosphodiesterase 1TDP1 interacts with LIG3-beta.-Pubmed
HPRDligase III, DNA, ATP-dependent isoform alphaXRCC1--Pubmed
BINDligase III, DNA, ATP-dependent isoform alphatyrosyl-DNA phosphodiesterase 1TDP1 interacts with LIG3-alpha.-Pubmed
BINDligase III, DNA, ATP-dependent isoform alphanei endonuclease VIII-like 1DNA Ligase III- alpha interacts with Neil1.-Pubmed

Recent Publications on LIG3:

Pubmed Logo
DNA repair gene polymorphisms and risk of pancreatic cancer.
PURPOSE: The current research was undertaken to examine the association...
21st July, 2009
Department of Gastrointestinal Medical Oncology, M. D. Anderson Cancer Clin Cancer Res. 2009 Jan 15;15(2):740-6.
DOI Direct Link
Common variants at ten loci influence QT interval duration in the QTGEN Study.
QT interval duration, reflecting myocardial repolarization on the...
15th May, 2009
Center for Human Genetic Research, Cardiovascular Research Center, Nat Genet. 2009 Apr;41(4):399-406. Epub 2009 Mar 22.
DOI Direct Link
Gene expression profiles in radiation workers occupationally exposed to ionizing radiation.
Ionizing radiation (IR) imposes risks to human health and the environment....
31st March, 2009
Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto-USP, Av J Radiat Res (Tokyo). 2009 Jan;50(1):61-71.
Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.
We have developed a microfluidic chip-based qualitative assay for...
20th February, 2009
Institute for Human Genetics, Johannes Gutenberg University Mainz, 55101 Biol Reprod. 2009 Jan;80(1):194-202. Epub 2008 Sep 10.
DOI Direct Link
Microarray-based expression of DNA repair genes does not correlate with growth inhibition of cancer cells by natural products derived from traditional Chinese medicine.
Drug resistance represents a major obstacle in cancer chemotherapy. As...
18th September, 2008
Pharmaceutical Biology (C015), German Cancer Research Center, Heidelberg, Cancer Genomics Proteomics. 2008 Mar-Apr;5(2):79-84.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
6469720 Electronic device comprising a screen and method of displaying short menus
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

LIG3 results (if any) from reagent suppliers

Google CSE Logo
Biotin Anti-PARP Antibody - BioLegend
PARP interacts with proteins in the base excision repair complex containing at least XRCC1, PARP2, POLB and LIG3. In addition PARP forms heterodimers with ...
http://www.biolegend.com/biotin-anti-parp-antibody-3635.html...

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DNA Ligase III (6G9) Antibody sc-56089
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, LIG3, 3980, 17q12, NM_002311, ...
http://www.scbt.com/datasheet-56089-dna-ligase-iii-6g9-antib...

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PARP cleaved antibody, PARP cleaved Antibody, Rabbit Polyclonal ...
Subunit: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. ...
http://www.genwaybio.com/product_info.php?products_id=197373...

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DNA Ligase III siRNA (m) sc-72086
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Lig3, 16882, 11 C, P97386 ...
http://www.scbt.com/datasheet-72086-dna-ligase-iii-sirna-m.h...

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Cellular Mechanisms and Cancer
a non-reactive binding site for Polβ, and bring the Polβ and LIG3 ... is performed by LIG3, which connects the deoxyribose of the ...
https://www.sigmaaldrich.com/etc/medialib/docs/Sigma/General...

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