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LRP1


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Symbol:LRP1
Name(s):low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
Type:protein-coding
Organism:Homo sapiens
Synonyms:A2MR, APOER, APR, CD91, FLJ16451, IGFBP3R, LRP, MGC88725, TGFBR5
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18317248 Observational study of gene-disease association. (HuGE Navigator)
17694066 Soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for amyloid beta in humans.
11076057 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
11436125 Observational study of gene-disease association. (HuGE Navigator)
11600564 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
11720768 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
11931574 Observational study of gene-disease association. (HuGE Navigator)
12394648 Observational study of gene-disease association. (HuGE Navigator)
12402342 Observational study of gene-disease association. (HuGE Navigator)
12555245 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-2-macroglobulin precursorlow density lipoprotein-related protein 1--Pubmed
HPRDalpha-2-macroglobulin precursorlow density lipoprotein-related protein 1--Pubmed
BINDalpha-1-antichymotrypsin, precursorlow density lipoprotein-related protein 1LRP interacts with alpha-1-ACT.-Pubmed
HPRDamyloid beta A4 precursor protein-binding, family B, member 1 isoform E9low density lipoprotein-related protein 1--Pubmed
HPRDamyloid beta A4 precursor protein-binding, family B, member 1 isoform E9low density lipoprotein-related protein 1--Pubmed
HPRDApolipoprotein Elow density lipoprotein-related protein 1--Pubmed
HPRDapolipoprotein E precursorLow density lipoprotein receptor-related protein 1--Pubmed
HPRDAmyloid beta A4 proteinlow density lipoprotein-related protein 1--Pubmed
HPRDamyloid beta A4 protein precursor, isoform aLow density lipoprotein receptor-related protein 1--Pubmed
HPRDcomplement component 3 precursorlow density lipoprotein-related protein 1--Pubmed

Recent Publications on LRP1:

Pubmed Logo
Proteomic analysis of GLUT4 storage vesicles (GSVS) reveals low-density lipoprotein receptor-related protein 1 (LRP1) to be an important vesicle component and target of insulin signaling.
Insulin stimulates the translocation of intracellular GLUT4 to the plasma...
30th October, 2009
Boston University School of Medicine, United States; J Biol Chem. 2009 Oct 28.
DOI Direct Link
Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse.
Loading-related changes in gene expression in resident cells in the tibia...
28th October, 2009
Department of Veterinary Basic Sciences, The Royal Veterinary College, Bone. 2009 Oct 24.
DOI Direct Link
Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.
The proximal NPXY and distal NPXYXXL motifs in the intracellular domain of...
27th October, 2009
Laboratory for Experimental Mouse Genetics, Center for Human Genetics, KU Cell Mol Life Sci. 2009 Oct 25.
DOI Direct Link
RECEPTOR-ASSOCIATED PROTEIN (RAP) INTERACTS WITH AMYLOID-{beta} (A{beta}) PEPTIDE AND PROMOTES ITS CELLULAR UPTAKE.
Brain amyloid-beta (Abeta) peptide accumulation and aggregation are...
15th October, 2009
Washington University School of Medicine, United States; J Biol Chem. 2009 Oct 13.
DOI Direct Link
LRP1 receptor controls adipogenesis and is up-regulated in human and mouse obese adipose tissue.
The cell surface low-density lipoprotein receptor-related protein 1, LRP1,...
14th October, 2009
IRCM, Institut de Recherche en Cancerologie de Montpellier, INSERM, U896, PLoS One. 2009 Oct 12;4(10):e7422.
DOI Direct Link

View more research publications.

Press Releases on LRP1:

BioPortfolio Logo
Alzheimer's Gene Slows Brain's Ability to Export Toxic Protein 14th November, 2008 University of Rochester Medical Center

ROCHESTER, N.Y., Nov. 14 /PRNewswire-USNewswire/ -- The only known genetic risk factor for Alzheimer's disease slows down the brain's ability to export a toxic protein known as amyloid

BioNews Results for LRP1

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BioPortfolio Logo
Proteomic analysis of GLUT4 storage vesicles (GSVS) reveals low-density lipoprotein receptor-related protein 1 (LRP1) to be an important vesicle component and target of insuli...
Research & Development:  Oct 30 2009 12:08AM Matching: lrp1

Patents:

Patents logo
US Patent No.Title
7012131 Pro1410 polypeptides
7071304 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7074912 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7081514 PRO1347 polypeptides
7083946 PRO1343 nucleic acids

View more patents.

LRP1 results (if any) from reagent suppliers

Google CSE Logo
LRP1 (5A6) Antibody sc-57351
LRP1 shRNA (h) Lentiviral Particles, sc-40101-V, 200 µl ... Indirect FCM analysis of HepG2 cells stained with LRP1 (5A6), followed by PE-conjugated goat
...
http://www.scbt.com/datasheet-57351-lrp1-5a6-antibody.html...

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LRP1 Antibody (C-term)
LRP1 Antibody (C-term). Purified Rabbit Polyclonal Antibody (Pab) ... LRP1 Antibody (C-term). Formalin-fixed and paraffin-embedded human cancer tissue ...
http://www.abgent.com/products/catalog_no/AP6153a...

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LRP1 (A2MRα-2) Antibody sc-19616
See how others have used LRP1 (A2MRα-2): sc-19616 antibody and or LRP1 (A2MRα-2) ... LRP1 (A2MRα-2) PE: sc-19616 PE. FCM analysis of human peripheral blood ...
http://www.scbt.com/datasheet-19616-lrp1-a2mralpha-2-antibod...

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Antibodies for Alzheimer's and Neurodegenerative Disease Research
L2170, Anti-LRP1 (C-terminal) antibody produced in rabbit New, IgG fraction of antiserum ... SAB1400154, Anti-LRP1 antibody produced in mouse New ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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LRP Antibody / LRP Antibodies
LRP1 (A-18) Antibody, sc-16168, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h ... p-LRP1 (Tyr 4507) Antibody, sc-33049, rabbit IgG, Tyr 4507 (h), WB, IF, ...
http://www.scbt.com/table-low_density_lipoprotein.html...

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Recombinant Human LRP1 Cluster IV Fc Chimera
Recombinant Human LRP1 Cluster IV Fc. Chimera. Catalog Number: 5395L4. Background. LDL receptorrelated protein 1 (LRP1), also known ...
http://www.rndsystems.com/pdf/5395-L4.pdf...

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LRP1 (H-80) Antibody sc-25469
See how others have used LRP1 (H-80): sc-25469 antibody and or LRP1 (H-80) antibody ... Western blot analysis of human recombinant LRP1 fusion protein. ...
http://www.scbt.com/datasheet-25469-lrp1-h-80-antibody.html...

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