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LRP2


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Gene DB Home
Symbol:LRP2
Name(s):low density lipoprotein-related protein 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:DBS, gp330
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18174661 confirm the association between LRP2 and levels of T-Cho and LDL-C in human plasma
12768436 Observational study of genotype prevalence. (HuGE Navigator)
17457342 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18174661 Observational study of gene-disease association. (HuGE Navigator)
18070591 These results suggest that Dab2 is a ligand dependent bi-directional regulator of ERK1,2 activity.
17979745 This review summarizes recent data on the biological function of megalin and focuses on its implication in embryonic nutrition and central nervous system malformations.
17555532 Results show that the PPPSP motif and GSK3 activity are critical to allow megalin phosphorylation and also negatively regulate the receptor's recycling.
17632512 Study mapped Donnai-Barrow syndrome to chromosome 2q23.3-31.1 and identified LRP2 mutations in six families with Donnai-Barrow syndrome and one family with facio-oculo-acoustico-renal syndrome.
14657389 megalin has a role in thyroid homeostasis with possible implications in thyroid diseases
15134832 a binding affinity of disabled homolog 2 mitogen-responsive phosphoprotein interaction domain for megalin CT of K(D) = 2.6 x 10(-7) +/- 5.3 x 10(-8)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAlbuminlow density lipoprotein-related protein 2--Pubmed
HPRDalbumin precursorlow density lipoprotein-related protein 2--Pubmed
HPRDamyloid beta A4 precursor protein-binding, family B, member 1 isoform E9low density lipoprotein-related protein 2--Pubmed
HPRDApolipoprotein Blow density lipoprotein-related protein 2--Pubmed
HPRDapolipoprotein B precursorLow density lipoprotein related protein 2--Pubmed
HPRDApolipoprotein Elow density lipoprotein-related protein 2--Pubmed
HPRDapolipoprotein E precursorLow density lipoprotein related protein 2--Pubmed
HPRDApolipoprotein Hlow density lipoprotein-related protein 2--Pubmed
HPRDapolipoprotein H precursorLow density lipoprotein related protein 2--Pubmed
HPRDclusterinlow density lipoprotein-related protein 2--Pubmed

Recent Publications on LRP2:

Pubmed Logo
PET imaging of leptin biodistribution and metabolism in rodents and primates.
We have determined the systemic biodistribution of the hormone leptin by...
9th October, 2009
Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Cell Metab. 2009 Aug;10(2):148-59.
DOI Direct Link
Identification of glycoproteins carrying a target glycan-motif by liquid chromatography/multiple-stage mass spectrometry: identification of Lewis x-conjugated glycoproteins in mouse kidney.
Certain glycan motifs in glycoproteins are involved in several biological...
24th September, 2009
Division of Biological Chemistry and Biologicals, National Institute of J Proteome Res. 2009 Jul;8(7):3415-29.
DOI Direct Link
Metallothionein-I+II in neuroprotection.
Metallothionein (MT)-I+II synthesis is induced in the central nervous...
6th August, 2009
Section of Neuroprotection, Institute of Neuroscience and Pharmacology, Biofactors. 2009 Jul-Aug;35(4):315-25.
DOI Direct Link
A 56-year-old female patient with facio-oculo-acoustico-renal syndrome (FOAR) syndrome. Report on the natural history and of a novel mutation.
The facio-oculo-acoustico-renal syndrome (FOAR) is a rare autosomal...
7th July, 2009
Institut Jerome Lejeune, Paris, France. Eur J Med Genet. 2009 Sep-Oct;52(5):341-3. Epub 2009 Jul 3.
DOI Direct Link
Effects of receptor-mediated endocytosis and tubular protein composition on volume retention in experimental glomerulonephritis.
Human glomerulonephritis (GN) is characterized by sustained proteinuria,...
3rd June, 2009
Charite-Universitatsmedizin Berlin, Institut fur Vegetative Anatomie, Am J Physiol Renal Physiol. 2009 Apr;296(4):F902-11. Epub 2009 Feb 4.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6555654 LDL-receptor
7067636 Anti-pro 1017 antibodies
7074593 PRO 703 nucleic acids
7081521 Anti-PRO788 antibodies
7105640 Anti-pro792 antibodies

View more patents.

LRP2 results (if any) from reagent suppliers

Google CSE Logo
Lrp2 / Megalin antibody (ab21849) | Abcam
Mouse polyclonal to Lrp2 / Megalin. Lrp2 belongs to the LDLR family and contains 17 EGF-like domains, 36 LDL-receptor class A domains and 37 LDL-receptor ...
http://www.abcam.com/Lrp2-Megalin-antibody-ab21849.html...

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LRP2 (Megalin) Antibody (C-term)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP2. Other Names
: ...
http://www.abgent.com/products/catalog_no/AP6154a...

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Lrp2 / Megalin antibodies: Stem Cells > Lineage Markers > Endoderm ...
Lrp2 / Megalin antibodies. ... Lrp2 / Megalin antibody. WB. Images. Mouse polyclonal ... Lrp2 / Megalin antibody. WB, ELISA. Rabbit polyclonal. Reacts
with: ...
http://www.abcam.com/index.html?t=115434&pt=1&c=3435&ei=&mu=...

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megalin (H-245) Antibody sc-25470
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, LRP2, 4036, 2q31.1, NM_004525 ...
http://www.scbt.com/datasheet-25470-megalin-h-245-antibody.h...

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Cell Surface Molecules / GPCRs
low-density lipoprotein receptor-related protein 2 (LRP2) polyclonal antibody, PAB-10775, $175.00. low-density lipoprotein receptor-related protein 3 (LRP3)
...
http://www.orbigen.com/dictionary/cat1089.htm...

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megalin siRNA (m) sc-40104
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Mouse, Lrp2, 14725, 2 C2, A2ARV4 ...
http://www.scbt.com/datasheet-40104-megalin-sirna-m.html...

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Abgent Antibodies and Peptides
AP7813a, LIMK1 (N-term), IHC, WB, H. AP6153a, LRP1 (C-term), IHC, H. AP6152a, LRP15 (C-term), IHC, WB, H. AP6154a, LRP2 (C-term), IHC, H ...
http://www.abgent.com/docs/kits_neurosciences...

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