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ARNT


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Symbol:ARNT
Name(s):aryl hydrocarbon receptor nuclear translocator
Type:protein-coding
Organism:Homo sapiens
Synonyms:HIF-1beta, HIF1B, HIF1BETA, TANGO
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
11393538 Observational study of gene-disease association. (HuGE Navigator)
11835227 Observational study of gene-disease association. (HuGE Navigator)
16084889 Observational study of gene-disease association. (HuGE Navigator)
16364012 Observational study of gene-disease association. (HuGE Navigator)
17559847 Observational study of gene-disease association. (HuGE Navigator)
17559847 Allele and genotype frequencies of AHR and ARNT polymorphisms were similar between infertile men and controls.
12586752 experiments revealed a complex distribution of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator mRNAs and proteins in rat and human testis
16111650 Ainp2 enhances the 3-methylchloranthrene-induced activity in HepG2 cells, suggesting that Ainp2 plays a role in the Arnt-dependent function.
16520375 for the bHLH.PAS transcription factors Dioxin Receptor and Arnt, the DR PAS A domain has a role in dimerization and affinity for an atypical E-box DNA sequence
14638687 formation of stable protein-DNA complexes by DR/Arnt and HIF-1alpha/Arnt heterodimers with their cognate DNA sequences requires Per/Arnt/Sim A domains

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAryl hydrocarbon receptoraryl hydrocarbon receptor nuclear translocator isoform 1--Pubmed
HPRDaryl hydrocarbon receptorAryl hydrocarbon receptor nuclear translocator--Pubmed
BINDaryl hydrocarbon receptoraryl hydrocarbon receptor nuclear translocator isoform 1Arnt interacts with AhR.-Pubmed
HPRDAryl hydrocarbon receptor nuclear translocatorendothelial PAS domain protein 1--Pubmed
BIND-endothelial PAS domain protein 1HLF interacts with Arnt. This interaction was modeled on a demonstrated interaction between mouse HLF and human Arnt.-Pubmed
HPRDAryl hydrocarbon receptor nuclear translocatorhypoxia-inducible factor 1, alpha subunit isoform 1--Pubmed
BIND-neuronal PAS domain protein 1NPAS1 interacts with Arnt-Pubmed
HPRDAryl hydrocarbon receptor nuclear translocatoraryl hydrocarbon receptor interacting protein--Pubmed
HPRDAryl hydrocarbon receptor nuclear translocatorsingle-minded homolog 1--Pubmed
HPRDAryl hydrocarbon receptor nuclear translocatorsingle-minded homolog 2 long isoform--Pubmed

Recent Publications on ARNT:

Pubmed Logo
Complex regulation of the transactivation function of hypoxia-inducible factor-1alpha by direct interaction with two distinct domains of the creb-binding protein/p300.
Activation of transcription in response to low oxygen tension is mediated...
3rd November, 2009
Karolinska Institutet, Sweden; J Biol Chem. 2009 Oct 30.
DOI Direct Link
Molecular imaging: into in vivo interaction of HIF-1alpha and HIF-2alpha with ARNT.
Fluorescence resonance energy transfer (FRET) combined with confocal laser...
3rd November, 2009
Institute for Physiology, University of Duisburg-Essen, Essen, Germany. Ann N Y Acad Sci. 2009 Oct;1177:74-81.
DOI Direct Link
Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene.
BACKGROUND: DJ-1 forms part of the neuronal cellular defence mechanism...
29th October, 2009
Division of Molecular Biology and Human Genetics, Faculty of Health BMC Med Genet. 2009 Oct 13;10:105.
DOI Direct Link
Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.
AIM: This study examined the efficacy of sertindole in comparison with a...
24th October, 2009
Bradford School of Pharmacy, The University of Bradford, Bradford, West Psychopharmacology (Berl). 2009 Oct 23.
DOI Direct Link
The Expression of AIP-Related Molecules in Elucidation of Cellular Pathways in Pituitary Adenomas.
Germline mutations in the aryl hydrocarbon receptor interacting protein...
24th October, 2009
From the Department of Medical Genetics,* Genome-Scale Biology Research Am J Pathol. 2009 Oct 22.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Molecular Epidemiology of Dioxin-Related Illness in Seveso

Patents:

Patents logo
US Patent No.Title
7345031 Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
7419992 Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders
7427489 Screening assay to identify modulators of the sleep/wake cycle
7432241 Device for treating diabetes and methods thereof
7435555 Asparagine hydroxylation of the CAD domain of a HIF protein

View more patents.

ARNT results (if any) from reagent suppliers

Google CSE Logo
HIF-1β/ARNT Antibody #3718
Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) derived from the sequence of human HIF-1β/ARNT. ...
http://www.cellsignal.com/products/3718.html...

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Arnt Antibody / Arnt Antibodies
Arnt Antibody / Arnt Antibodies. ... Arnt specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-arnt.html...

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HIF-1β/ARNT Antibody
HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with ... translocation leading to a TEL-ARNT fusion protein is as- ...
http://www.cellsignal.com/pdf/3718.pdf...

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Arnt 1 (H-172) Antibody sc-5580
See how others have used Arnt 1 (H-172): sc-5580 antibody and or Arnt 1 (H-172) ... Western blot analysis of Arnt 1 expression in untreated (A,C) and CoCl2 ...
http://www.scbt.com/datasheet-5580-arnt-1-h-172-antibody.htm...

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HIF1 beta antibody [2B10] (ab2771) | Abcam
Staining of ARNT in VT{2} cells (Hepa 1-C4T mutant deficient in ARNT function but stably transfected with the full length human ARNT cDNA) using ab2771 ...
http://www.abcam.com/HIF1-beta-antibody-2B10-ab2771.html...

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Arnt 2 (M-165) Antibody sc-5581
See how others have used Arnt 2 (M-165): sc-5581 antibody and or Arnt 2 ... Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in ...
http://www.scbt.com/datasheet-5581-arnt-2-m-165-antibody.htm...

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Anti-HIF-1 beta Monoclonal Antibody
Immunofluorescence staining of ARNT in VT{2} cells (Hepa 1-C4T mutant deficient ... Figure 1 shows a Western blot of ARNT on COS cell extract using MA1-515. ...
http://www.bioreagents.com/products/productDetails/productDe...

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