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M6PR


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Symbol:M6PR
Name(s):mannose-6-phosphate receptor (cation dependent)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD-MPR, FLJ32994, MPR46, SMPR
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15167696 Observational study of gene-disease association. (HuGE Navigator)
18003638 Observational study of gene-disease association. (HuGE Navigator)
15620351 All 5 MPRci-deficient lines resisted infection by cell-free, but not cell-associated, VZV, secreted lysosomal enzymes, and released infectious virions when infected by cell-associated VZV
12697764 sorting of the CD-MPR in late endosomes requires a distinct di-aromatic motif with only limited possibilities for variations
17210618 We conclude that the CI-MPR participates in lysosomal and granular targeting of serglycin and basic proteins such as lysozyme associated with the proteoglycan in hematopoietic cells.
12736721 M6P/IGF2R may be involved in HBV-associated hepatocarcinogenesis by the regulation of its expression level.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD-MPRrenin precursor--Pubmed
HPRDCD-MPRkinesin family member 13A--Pubmed
HPRDcation-dependent mannose-6-phosphate receptor precursorRenin--Pubmed
HPRDcation-dependent mannose-6-phosphate receptor precursorKinesin family member 13A--Pubmed
BINDcation-dependent mannose-6-phosphate receptor precursormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with M6PR (CD-MPR).-Pubmed
BINDcation-dependent mannose-6-phosphate receptor precursormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with M6PR (CD-MPR).-Pubmed
HPRDcation-dependent mannose-6-phosphate receptor precursorgolgi associated, gamma adaptin ear containing, ARF binding protein 1 isoform 1--Pubmed
HPRDcation-dependent mannose-6-phosphate receptor precursorADP-ribosylation factor binding protein 3 isoform long--Pubmed

Recent Publications on M6PR:

Pubmed Logo
PIKfyve regulation of endosome-linked pathways.
The phosphoinositide 5-kinase (PIKfyve) is a critical enzyme for the...
15th October, 2009
Secretory Pathways Laboratory, Cancer Research UK London Research Traffic. 2009 Jul;10(7):883-93.
Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.
The expression profile and functions of the brain-enriched Rab22B/Rab31...
3rd September, 2009
Department of Biochemistry, Yong Loo Lin School of Medicine, National J Cell Physiol. 2009 Dec;221(3):716-28.
DOI Direct Link
Gene silencing of mannose 6-phosphate reductase in the parasitic weed Orobanche aegyptiaca through the production of homologous dsRNA sequences in the host plant.
Orobanche spp. (broomrape) are parasitic plants which subsist on the roots...
3rd September, 2009
Department of Plant Pathology and Weed Research, ARO, The Volcani Center, Plant Biotechnol J. 2009 Aug;7(6):487-98. Epub 2009 May 21.
DOI Direct Link
EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.
Depletion of EHD3 affects sorting in endosomes by altering the kinetics...
28th April, 2009
Department of Biochemistry and Molecular Biology and Eppley Cancer Center, J Cell Sci. 2009 Feb 1;122(Pt 3):389-400. Epub 2009 Jan 12.
DOI Direct Link
Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion.
Membrane trafficking is an important cellular process that enables the...
2nd April, 2009
Department of Life Sciences, Graduate School of Arts and Sciences, The Genes Cells. 2009 Mar;14(3):355-69. Epub 2009 Feb 13.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6867348 Methods and compositions for screening for angiogenesis modulating compounds
6716579 Gene specific arrays, preparation and use
6706867 DNA array sequence selection

View more patents.

M6PR results (if any) from reagent suppliers

Google CSE Logo
Mannose 6 Phosphate Receptor (Cation independent) antibody [2G11 ...
Immunofluorescent staining using the M6PR antibody resulted in the visualisation of large peri-nuclear structures in methanol fixed HEK293 cells. ...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=2...

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M6PR Antibody (N-term)
Formalin-fixed and paraffin-embedded human testis tissue reacted with M6PR antibody (N-term) (Cat.#AP2792a), which was peroxidase-conjugated to the ...
http://www.abgent.com/products/catalog_no/AP2792a_M6PR_Antib...

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ORDERING INFORMATION
1 Apr 2009 ... Human CD-M6PR specific IgG was purified by human CD-M6PR affinity ... appropriate secondary reagents to detect human CD-M6PR. The detection ...
http://www.rndsystems.com/pdf/BAF5320.pdf...

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IGF2R antibody, CD222 MANNOSE-6 PHOSPHATE / IGF-2 RECEPTOR ...
MONOCLONAL ANTIBODY TO HUMAN CD222 MANNOSE-6 PHOSPHATE / IGF-2 RECEPTOR; CI Man- 6-P receptor; CI-MPR; M6PR; Insulin-like growth factor 2 receptor; ...
http://www.genwaybio.com/product_info.php?products_id=175190...

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CD-MPR (X-22) Antibody sc-133447
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, M6PR, 4074, 12p13.31, P20645 ...
http://www.scbt.com/datasheet-133447-cd-mpr-x-22-antibody.ht...

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VPS35 antibody (ab10099) | Abcam
It is an essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans
...
http://www.abcam.com/vps35-antibody-ab10099.html...

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Abgent - Stem Cell
AP1426c, Lmx1a Antibody (Center), WB, E, H, M. AP1435b, M Cadherin (CDH15) Antibody (C-term), WB, IHC, E, H. AP2792aNEW, M6PR Antibody (N-term), IHC, E, H
...
http://www.abgent.com/products/category/stem_cell...

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