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SMAD3
| Symbol: | SMAD3 | | Name(s): | SMAD family member 3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DKFZP586N0721, DKFZp686J10186, HSPC193, HsT17436, JV15-2, MADH3, MGC60396, Smad 3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18055455 |
SARS coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling |
| 17471513 |
The TGFB/SMAD3 signaling pathway is involved in butyrate-mediated vitamin D receptor expression. |
| 12202987 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 14727154 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16886151 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18095154 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18082619 |
These findings suggest that CLU regulates TGF-beta signaling pathway by modulating the stability of Smad2/3 proteins. |
| 18078810 |
Thus, SMCX is a novel Smad3 corepressor that may antagonize the tumor suppressing activity of the TGF-beta/Smad3 signaling pathway and thereby contribute to tumorigenesis. |
| 17934056 |
Recent studies highlighted in this review suggest that TGF-beta suppresses neoplastic cell development by employing Smad3 protein to repress the human telomerase reverse transcriptase gene. |
| 17908958 |
Smad3, through regulating angiogenic molecule expression in tumor cells, is critical for progression of prostate cancer | →View more information from publications. |
Recent Publications on SMAD3: |  |
A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis.
OBJECTIVE: Tissue fibrosis is a major cause of morbidity and mortality in... | 31st October, 2009
| Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
| Arthritis Rheum. 2009 Oct 29;60(11):3465-3475.
DOI Direct Link |
c-Ski promotes skin fibroblast proliferation but decreases type I collagen: implications for wound healing and scar formation.
Summary Background. Accelerating wound healing is always accompanied by... | 31st October, 2009
| Molecular Biology Center, State Key Laboratory of Trauma, Burn and
| Clin Exp Dermatol. 2009 Oct 23.
DOI Direct Link |
Receptor Type Protein Tyrosine Phosphatase-Kappa (RPTP-{kappa}) Mediates Cross-Talk between TGF-{beta} and EGFR Signaling Pathways in Human Keratinocytes.
Monitoring Editor: Jonathan Chernoff Epidermal growth factor receptor... | 30th October, 2009
| Department of Dermatology, University of Michigan, Ann Arbor, MI
| Mol Biol Cell. 2009 Oct 28.
DOI Direct Link |
Increased cAMP levels modulate transforming growth factor(TGF-{beta})/SMAD-induced expression of extracellular matrix components and other key fibroblast effector functions.
cAMP is a key messenger of a variety of hormones and neuropeptides some of... | 28th October, 2009
| Dept. of Dermatology and Ludwig Boltzmann Institute for Cell Biology and
| J Biol Chem. 2009 Oct 26.
DOI Direct Link |
Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.
We report that infection of draining lymph nodes (DLNs) by Salmonella... | 27th October, 2009
| Department of Immunology, Duke University Medical Center, Durham, North
| Nat Med. 2009 Oct 25.
DOI Direct Link |
→View more research publications. |
SMAD3 results (if any) from reagent suppliers | 
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