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ACCN2


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Symbol:ACCN2
Name(s):amiloride-sensitive cation channel 2, neuronal
Type:protein-coding
Organism:Homo sapiens
Synonyms:ASIC, ASIC1, ASIC1A, BNaC2, hBNaC2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18349698 Observational study of gene-disease association. (HuGE Navigator)
17984098 endogenous peptides shift steady-state desensitization suggests that RF-amides could impact the role of ASIC1a in both pain and neuronal damage following stroke and ischemia.
17548344 AKAP150 and the protein phosphatase calcineurin are binding proteins to ASIC2a, and calcineurin regulates ASIC1a and ASIC2a activity
15574747 Ibuprofen studies show ASIC1a is a significant contributor to cutaneous acid-induced pain.
17443677 Spontaneous currents represent activation of acid-sensitive ion channels (ASICs) by autocrine vesicular release of protons from HEK cells.
12244121 participation of multiple PKC isotypes contributes to the overall activity of BNaC2
14988500 ASIC1a and H(+)-gated currents may contribute to the development of abnormal fear and to anxiety disorders.
12393854 ASICs are leading acid sensors in human nociceptors and VR1 participates in the nociception mainly under extremely acidic conditions.
17392378 Sulfhydryl compounds potentiate H(+)-gated currents via two mechanisms, metal chelation and redox modulation of target amino acids.
15576453 These observations strongly suggest the acid-induced current is mediated by ASIC1 channels.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBNC1amiloride-sensitive cation channel 2, neuronal isoform a--Pubmed
HPRDamiloride-sensitive cation channel 1, neuronal isoform 1Brain sodium channel 2--Pubmed
HPRDBrain sodium channel 2protein interacting with C kinase 1--Pubmed
BINDamiloride-sensitive cation channel 2, neuronal isoform bprotein interacting with C kinase 1PICK1 interacts with ASIC.-Pubmed
HPRDamiloride-sensitive cation channel 2, neuronal isoform aProtein kinase C, alpha binding protein--Pubmed
HPRDamiloride-sensitive cation channel 2, neuronal isoform aamiloride-sensitive cation channel 2, neuronal isoform a--Pubmed

Recent Publications on ACCN2:

Pubmed Logo
Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders.
OBJECTIVE: Ion channels are involved in a wide range of central nervous...
29th April, 2008
Department of Psychiatry, Virginia Institute for Psychiatric and Psychiatr Genet. 2008 Apr;18(2):73-9.
DOI Direct Link

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods
7258971 Methods and compositions for treating urological disorders using carboxypeptidase Z identified as 8263

View more patents.

ACCN2 results (if any) from reagent suppliers

Google CSE Logo
ACCN2 antibody - Extracellular domain (ab81058) | Abcam
Sheep polyclonal to ACCN2 - Extracellular domain. ACCN2 belongs to the degenerin /epithelial sodium channel (DEG/ENaC) superfamily.
http://www.abcam.com/ACCN2-antibody-Extracellular-domain-ab8...

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Anti-ACCN2 Polyclonal Antibody
Polyclonal Antibody against ACCN2 for use in Immunohistochemistry, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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Antibodies to Sodium Channels
human ... ACCN2(41) mouse ... Accn2(11419), rat, human, mouse, IHC, WB, pricing. S5070, Anti-Sodium Channel ASIC3 antibody produced in rabbit, (polyclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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ASIC1 (H-70) Antibody sc-28756
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, ACCN2, 41, 12q13.13, NM_001095, ...
http://www.scbt.com/datasheet-28756-asic1-h-70-antibody.html...

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Primary antibodies | Abcam
ACCN2 antibody. IHC-P, WB, IHC-Fr. Images. Rabbit polyclonal. Reacts with: Hu, Rat. ab81058 · ACCN2 antibody - Extracellular domain. IHC-P, WB, IHC-Fr ...
http://www.abcam.com/index.html?pageconfig=catalog_byproduct...

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Anti-ASIC1 (Amiloride-sensitive brain sodium channel, BnaC2, ACCN2)
(Amiloride-sensitive brain sodium channel, BnaC2, ACCN2). Product#: ASC-014. Sizes: 50 ml. 0.2 ml. ASIC1 is a member of a family of Na+ channels that are ...
http://www.alomone.com/p_postcards/database/288.htm...

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Abcam antibodies and reagents product map
ACCN1 antibodies (3) · ACCN2 antibodies (2) · ACCN4 antibodies (2) · ACCN5 antibodies (2) · APXL antibodies (3) · APXL proteins and peptides (1) ...
http://www.abcam.com/index.html?cl=248&pageconfig=productmap...

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