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MAGEA3


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Symbol:MAGEA3
Name(s):melanoma antigen family A, 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:HIP8, HYPD, MAGE3, MAGEA6, MGC14613
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18181974 Measurement of Melan-A, gp100, MAGE-3, MIA and tyrosinase represents a prognostic factor and a method for early detection of metastasis and treatment response of melanoma patients.
18197853 Multiple simultaneous detection of MAGE-A [subtypes] more specific and sensitive than detection of single MAGE-A antigen for the diagnostic and prognostic evaluation of oral squamous cell carcinoma
17699848 Gene expression profiling identified the cancer/testis antigen MAGE-A3/6 as a novel target of FGFR2-IIIb signaling.
17495964 the MAGE-A3 and MAGE-C2 gene promoter regions are de-methylated in the presence of activated KIT but become methylated on inhibition of KIT, consistent with the downregulation of mRNA and protein
17634428 These data show, for the first time, the involvement of methyl-CpG binding domain proteins in the regulation of the MAGE-A genes.
15885805 first evidence that the naturally processed MAGE-3(271-279) can be isolated and identified from the tumor tissue of hepatocellular carcinoma patient
12710945 This melanoma-associated marker was detected in melanoma cell lines.
16516880 Detection of aberrant methylation patterns of MAGEs CpG islands using Methylation-special PCR may be useful for diagnosis of Hepatocellular Carcinoma.
12393675 Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3
14672620 Spontaneous in vivo priming of MAGE-specific T cell response and high frequency of MAGE1 and MAGE3 expression in hepatocellular carcinoma makes this antigen potential candidate for MAGE-specific immunotherapy in hepatocellular carcinoma.

View more information from publications.

Recent Publications on MAGEA3:

Pubmed Logo
Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and cross-presenting function.
Ability to cross-present exogenous antigens in the human leukocyte antigen...
9th October, 2009
Department of Otolaryngology, University of Pittsburgh Cancer Institute, J Immunother. 2009 Jun;32(5):465-73.
DOI Direct Link
Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines.
BACKGROUND: The immunological response to solid tumours is insufficient....
9th October, 2009
Dpt of Oral and Maxillofacial Plastic Surgery, University Hospital Head Face Med. 2009 Apr 9;5:10.
DOI Direct Link
Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes.
Sera of patients with cancer contain membraneous microvesicles (MV) able...
24th September, 2009
Department of Pathology, University of Pittsburgh School of Medicine, J Immunol. 2009 Sep 15;183(6):3720-30. Epub 2009 Aug 19.
DOI Direct Link
Quantitative expression and immunogenicity of MAGE-3 and -6 in upper aerodigestive tract cancer.
The MAGE antigens are frequently expressed cancer vaccine targets....
22nd September, 2009
Department of Otolaryngology, University of Pittsburgh Cancer Institute, Int J Cancer. 2009 Oct 15;125(8):1912-20.
DOI Direct Link
The detection of peripheral lung cancer by MAGE A1-6 RT-nested PCR in bronchial washing specimens.
BACKGROUND: With expansion of lung cancer screening by computed tomography...
10th September, 2009
Department of Thoracic and Cardiovascular Surgery, Seoul National Lung Cancer. 2009 Aug;65(2):166-9. Epub 2009 Jan 24.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Immunization With the MAGE-3.A1 Peptide Mixed With the Adjuvant CpG 7909 in Patients With Metastatic Melanoma

Patents:

Patents logo
US Patent No.Title
7608394 Methods and compositions for phenotype identification based on nucleic acid methylation
7547551 Transfection of eukaryontic cells with linear polynucleotides by electroporation
7488793 Isolated peptide which binds to HLA-Cw*07 and uses thereof
7388072 MAGE peptides presented by HLA class II molecules
7371845 MAGE-A3 peptides presented by HLA class II molecules

View more patents.

MAGEA3 results (if any) from reagent suppliers

Google CSE Logo
MAGE-A3/6 (F-14) Antibody sc-33233
goat polyclonal IgG, 200µg/ml; epitope mapping within an internal region of MAGE -A3 of human origin; recommended for detection of MAGE-A3 and MAGE-A6 of ...
http://www.scbt.com/datasheet-33233-mage-a3-6-f-14-antibody....

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MAGEA3 Antibody (C-term)
MAGEA3 Antibody (C-term). The anti-MAGEA3 C-term Antibody (Cat.#AP6165a) is used in Western blot to detect MAGEA3 in Jurkat lysate. ...
http://www.abgent.com/products/catalog_no/AP6165a_MAGEA3_Ant...

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MAGE-A3/6 (C-13) Antibody sc-33234
Product Name, Catalog #, Unit, Price, Qty, Wish List. MAGE-A3/6 (C-13), sc-33234 , 200 µg/ml, $259. MAGE-A3/6 (C-13) P, sc-33234 P (peptide), 100 µg/0.5 ml ...
http://www.scbt.com/datasheet-33234-mage-a3-6-c-13-antibody....

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MAGEA3 antibodies: Cancer > Tumor immunology > Tumor-associated ...
MAGEA3 antibodies. ... MAGEA3 antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: Hu. ab52706 · MAGEA3 antibody. WB. Images. Mouse polyclonal ...
http://www.abcam.com/index.html?t=115807&pt=1&c=4315&ei=&mu=...

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MAGE-A3/6 (C-13) Antibody sc-33234
MAGE-A3/6 (C-13) Antikörper sc-33234 MAGE-A3/6 (C-13) Antibody sc-33234.
http://www.scbt.com/de/datasheet-33234-mage-a3-6-c-13-antibo...

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Oncoproteins
melanoma antigen family A 2 (MAGEA2) polyclonal antibody, PAB-10792, $175.00. Melanoma antigen family A 3 (MAGEA3) polyclonal antibody, PAB-10793, $175.00 ...
http://www.orbigen.com/dictionary/cat1054.htm...

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MAGE Antibody / MAGE Antibodies
MAGE-A3/6 (C-13) Antibody, sc-33234, goat IgG, C-terminus (h), WB, IF, ELISA ... MAGE-A3/6 (G-22) Antibody, sc-130809, rabbit IgG, N/A, WB, IP, ELISA, human ...
http://www.scbt.com/table-mage.html...

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