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MAGEA4

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Symbol:	MAGEA4
Name(s):	melanoma antigen family A, 4
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B, MGC21336
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18197853	Multiple simultaneous detection of MAGE-A [subtypes] more specific and sensitive than detection of single MAGE-A antigen for the diagnostic and prognostic evaluation of oral squamous cell carcinoma
12209997	strong MAGE-A4 expression and to a lesser degree NY-ESO-1 expression is characteristic of the vast majority of uterine carcinosarcomas and a major subset of papillary serous carcinomas
16596224	Expression may represent potential targets for cancer immunotherapy in patients with non small cell lung carcinoma.
12525503	MAGE-A4 binds to gankyrin and suppresses its oncogenic activity.
17214847	Expressed in a large part of epithelial skin tumors with predominantly scattered immunoexpression pattern in organ-transplant recipients.
14739298	a cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis
16061876	MAGE-A4(143-151) and SAGE(715-723) are HLA-A2402-restricted CTL epitopes
11985796	MAGE-4 protein may have a role in development of hepatocellular carcinogenesis in cirrhotic patients
16114059	Present, by immunocytochemistry, in normal prostate, prostatic hypertrophy and prostate cancer.
12209610	MAGE-A4 expression in bladder transitional cell carcinoma.
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	major histocompatibility complex, class I, A precursor	melanoma antigen, family A, 4	-	-	Pubmed
BIND	melanoma antigen, family A, 4	proteasome 26S non-ATPase subunit 10 isoform 1	MAGE-A4 interacts with gankyrin.	-	Pubmed

Recent Publications on MAGEA4:
Isolation, Characterization, and Culture of Human Spermatogonia. This study was designed to isolate, characterize, and culture human...	23rd October, 2009		Biol Reprod. 2009 Oct 21. DOI Direct Link
Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines. BACKGROUND: The immunological response to solid tumours is insufficient....	9th October, 2009	Dpt of Oral and Maxillofacial Plastic Surgery, University Hospital	Head Face Med. 2009 Apr 9;5:10. DOI Direct Link
The detection of peripheral lung cancer by MAGE A1-6 RT-nested PCR in bronchial washing specimens. BACKGROUND: With expansion of lung cancer screening by computed tomography...	10th September, 2009	Department of Thoracic and Cardiovascular Surgery, Seoul National	Lung Cancer. 2009 Aug;65(2):166-9. Epub 2009 Jan 24. DOI Direct Link
High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer. Cancer-testis (CT) genes encode proteins that are ideal targets for cancer...	21st August, 2009	Centre de recherche en cancerologie de l'Universite Laval, L'Hotel-Dieu de	Int J Cancer. 2009 Sep 15;125(6):1365-71. DOI Direct Link
[Detection rate of MAGE-A1-A6 mRNA in the peripheral blood of cancer patients] The mRNA expression of 6 MAGE-A (MAGE-A1-A6) antigens by the tumor focal...	11th July, 2009		Klin Lab Diagn. 2009 Apr;(4):25-7.
→View more research publications.

Patents:
US Patent No.	Title
7608394	Methods and compositions for phenotype identification based on nucleic acid methylation
7488793	Isolated peptide which binds to HLA-Cw*07 and uses thereof
7229760	mRNA amplification

MAGEA4 results (if any) from reagent suppliers

MAGEA4 Antibody (N-term) MAGEA4 Antibody (N-term). TOP: Immunostaining of paraformldehyde-fixed and paraffin-embedded human breast carcinoma with MAGE-A4 antibody Cat# AP6166a (1: 50 ... http://www.abgent.com/products/catalog_no/AP6166a_MAGEA4_Ant...
MAGEA4 antibodies: Cancer > Tumor biomarkers > Tumor antigens \| Abcam MAGEA4 antibodies. ... MAGEA4 antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: Hu. Terms and conditions · Legal · Privacy policy ... http://www.abcam.com/index.html?t=227342&pt=1&c=4377&ei=&mu=...
MAGE (Y-18) Antibody sc-12805 Mouse, Magea4, 17140, X A7.3, NP_064676, N/A. Mouse, Magea5, 17141, X F3, NP_064402, N/A. Mouse, Magea6, 17142, X F3, NP_064403 ... http://www.scbt.com/datasheet-12805-mage-y-18-antibody.html...
Oncoproteins Melanoma antigen family A 3 (MAGEA3) polyclonal antibody, PAB-10793, $175.00. Melanoma antigen family A 4 (MAGEA4) polyclonal antibody, PAB-10794, $175.00 ... http://www.orbigen.com/dictionary/cat1054.htm...
Abgent - Transcription and Regulation Antibodies ... AP6166a, MAGEA4 Antibody (N-term), WB, IHC, E, H. AT2762aNEW, MAGEA4 monoclonal antibody (M01), ELISA,IF,S-ELISA,WB-Ce, H. AP6167a, MAGEA5 Antibody (N-term) ... http://www.abgent.com/products/category/nuclear_signaling/tr...
Oncoproteins - Orbigen Inc. - Orbigen Inc. PAB-10794, Melanoma antigen family A 4 (MAGEA4) polyclonal antibody · NM_002362, 100 µg, $210.00. PAB-10795, Melanoma antigen family A 5 (MAGEA5) polyclonal ... http://www.orbigen.com/commerce/catalog/spcategory.jsp?categ...
Abgent - Chromatin and Regulation Antibodies - Chromatin_regulation AP6164a, MAGEA2 Antibody (N-term), WB, IHC, E, H. AP6165a, MAGEA3 Antibody (C- term), WB, E, H. AP6166a, MAGEA4 Antibody (N-term), WB, IHC, E, H ... http://www.abgent.com/products/category/nuclear_signaling/ch...

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MAGEA4

Gene Information from Publications

Interacting gene products

Recent Publications on MAGEA4:

Patents:

MAGEA4 results (if any) from reagent suppliers