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MBD1


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Symbol:MBD1
Name(s):methyl-CpG binding domain protein 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:CXXC3, PCM1, RFT
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16284366 Observational study of gene-disease association. (HuGE Navigator)
17634428 These data show, for the first time, the involvement of methyl-CpG binding domain proteins in the regulation of the MAGE-A genes.
16432238 PML-RARalpha functions by recruiting an HDAC3-MBD1 complex that contributes to the establishment and maintenance of the silenced chromatin state
16998846 Sex-specific time windows for concomitant upregulation of MBD1 are associated with prenatal remethylation of the human male and female germ line.
12711603 Suv39h1 enhanced MBD1-mediated transcriptional repression via MBD, not the C-terminal transcriptional repression domain of MBD1. MBD1 links to histone deacetylases through Suv39h1, causing methylation and deacetylation of histones for gene inactivation
17428788 MBD1 and Polycomb group proteins have overlapping roles in epigenetic gene silencing and heterochromatin foci formation through their interactions.
15327775 Data show that the methyl-CpG binding protein MBD1 forms a stable complex with histone H3-K9 methylase SETDB1.
12770674 Additional evidence of variable expression in the Rett disorder phenotype is presented by a small mixed gender group of children with autistic disorder.
15691849 These data suggest that MBD1.MCAF1.SETDB1 complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control, and describe a new family member, MCAF2.
16757475 MBD1- and MCAF1-mediated heterochromatin formation involves SUMO modification

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDMethyl CpG binding domain protein 1suppressor of variegation 3-9 homolog 1--Pubmed
HPRDMethyl CpG binding domain protein 1chromobox homolog 5--Pubmed
HPRDmethyl-CpG binding domain protein 1 isoform 1HP1 alpha--Pubmed
HPRDmethyl-CpG binding domain protein 1 isoform 1SUV39H1--Pubmed
HPRDmethyl-CpG binding domain protein 1 isoform 1chromatin assembly factor 1, subunit A--Pubmed
HPRDmethyl-CpG binding domain protein 1 isoform 1chromatin assembly factor 1, subunit A--Pubmed
HPRDmethyl-CpG binding domain protein 1 isoform 1activating transcription factor 7 interacting protein--Pubmed
HPRDmethyl-CpG binding domain protein 1 isoform 1activating transcription factor 7 interacting protein--Pubmed
BINDmethyl-CpG binding domain protein 1 isoform 1activating transcription factor 7 interacting proteinMCAF1 interacts with MBD1.-Pubmed
BINDmethyl-CpG binding domain protein 1 isoform 1activating transcription factor 7 interacting protein 2MCAF2 interacts with MBD1.-Pubmed

Recent Publications on MBD1:

Pubmed Logo
Specific association between the Methyl-CpG binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells.
Human telomerase reverse transcriptase (hTERT) is expressed in most cancer...
28th October, 2008
INSERM, U590, Lyon, F-69008, France. Carcinogenesis. 2008 Oct 24.
DOI Direct Link
Structure of the sumo-interacting motif of MCAF1 bound to sumo-3.
Posttranslational modification by small ubiquitin-like modifier (SUMO)...
10th October, 2008
Molecular Engineering, Kyoto University, Kyoto 615-8510. J Biol Chem. 2008 Oct 7.
DOI Direct Link
Proteomic analysis of differential proteins in pancreatic carcinomas: Effects of MBD1 knock-down by stable RNA interference.
BACKGROUND: Methyl-CpG binding domain protein 1 (MBD1), a suppressor of...
10th October, 2008
Pancreatic Disease Institute, Department of General Surgery, Huashan BMC Cancer. 2008 Apr 29;8:121.
DOI Direct Link
Evolution of DNA-methylation machinery: DNA methyltransferases and methyl-DNA binding proteins in the amphioxus Branchiostoma floridae.
DNA methylation is an epigenetic mark associated with gene regulation and...
25th September, 2008
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Dev Genes Evol. 2008 Sep 24.
DOI Direct Link
Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.
BACKGROUND: Analysis of biopsies from a recent clinical trial suggested...
19th August, 2008
Department of Pathology, Institute of Basic Medical Sciences, Beijing, Cancer Biol Ther. 2008 Sep;7(9):1388-97. Epub 2008 Sep 2.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7425415 Method for detecting methylated CpG islands
6933113 Modulation of endogenous gene expression in cells
6919204 Modulation of gene expression using localization domains
6914049 IGF-binding protein-derived peptide or small molecule
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

View more patents.

MBD1 results (if any) from reagent suppliers

Google CSE Logo
MBD1 methyl-CpG binding domain protein 1
WH0004152M2, Monoclonal Anti-MBD1 antibody produced in mouse clone 2C7, purified immunoglobulin, buffered aqueous solution, human ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

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MBD1 Antibody (C-term)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/catalog_no/AP1036b...

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MBD1 (G-18) Antibody sc-9395
See how others have used MBD1 (G-18): sc-9395 and or MBD1 (G-18) antibody conjugates. Chadwick B.P. et al. 2002. Cell cycle–dependent localization of ...
http://www.scbt.com/datasheet-9395-mbd1-g-18-antibody.html...

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M6569 Anti MBD1 antibody produced in rabbit ~1 mg/mL, affinity ...
M6569 Anti-MBD1 antibody produced in rabbit ~1 mg/mL, affinity isolated antibody , buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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MBD1 (M-254) Antibody sc-10751
Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding ... MBD1 (M-254): sc-10751. Western blot analysis of MBD1 expression in
...
http://www.scbt.com/datasheet-10751-mbd1-m-254-antibody.html...

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MBD1 Antibody (N-term)
Western blot analysis of anti-MBD1 Pab (Cat. #AP1036a) in Jurkat cell lysate. MBD1 (Arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was ...
http://www.abgent.com/products/catalog_no/AP1036a...

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Anti-MBD1 Produced in rabbit, Affinity isolated antibody Product ...
MBD1 isoforms. The antibody is affinity-purified using. the immunizing peptide immobilized on ... MBD1 can act as a transcriptional repressor. The way it ...
http://www.sigmaaldrich.com/sigma/datasheet/M6569dat.pdf...

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MBD1 antibody - ChIP Grade (ab3753) reviews | Abcam
Rabbit polyclonal to MBD1 - ChIP Grade. DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper
...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=3...

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MBD1 siRNA (m) sc-35864
Recommended Control Antibody (click catalog # for product information). Product Name, Catalog #, Unit, Price, Qty, Wish List. MBD1 (B-5), sc-25261 ...
http://www.scbt.com/datasheet-35864-mbd1-sirna-m.html...

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MBD1 antibodies | Abcam
MBD1 antibodies. ... MBD1 antibody [100B272.1.] - ChIP Grade. WB, ChIP. Images · Specific publication references. Mouse monoclonal ...
http://www.abcam.com/index.html?t=10843&pt=1&c=558...

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