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CD46


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Symbol:CD46
Name(s):CD46 molecule, complement regulatory protein
Type:protein-coding
Organism:Homo sapiens
Synonyms:MCP, MGC26544, MIC10, TLX, TRA2.10
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17914026 Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome.
11844145 Observational study of gene-disease association. (HuGE Navigator)
16253969 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16621965 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17947513 It is concluded that the B1 and B2 species of Ad engage CD46 through similar binding surfaces.
17715217 SLAM and CD46 do not have a role in measles virus growth and syncytium formation in tumor cell lines
17560639 SNPs present in both the SLAM and CD46 genes are associated with measurable and significant variations in antibody response after measles vaccination
17617869 recurrence may be favored by vascular microchimerism, in which the mutated CD46 protein is produced in the in the kidney graft by endothelial cells originating from recipient.
17599974 posttransplantation outcome is poor in all complement mutation groups except for the MCP mutation group
12540904 Co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4+ T cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcomplement component 3 precursorCD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDcomplement component 3 precursorCD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDcomplement component 4B preproproteinCD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDcomplement component 4B preproproteinCD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDpostsynaptic density protein 95CD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDpostsynaptic density protein 95CD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDintegrin beta 1 isoform 1C-1 precursorCD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDintegrin beta 1 isoform 1C-1 precursorCD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDlethal giant larvae homolog 1CD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed
HPRDlethal giant larvae homolog 1CD46 antigen, complement regulatory protein isoform 1 precursor--Pubmed

Recent Publications on CD46:

Pubmed Logo
In this issue.
COVER IMAGE: This issue's cover features a composite of images showing...
3rd November, 2009
Eur J Immunol. 2009 Oct 30;39(11):2942-2943.
DOI Direct Link
Early expression changes of complement regulatory proteins (CRegs) and C5a receptor (CD88) on leukocytes after multiple injury in humans.
As a crucial element of innate immunity, the complement cascade becomes...
30th October, 2009
1Department of Traumatology, Hand-, Plastic- and Reconstructive Surgery Shock. 2009 Oct 27.
DOI Direct Link
Reduction of Neu5GC Xenoantigen on Human ADSC/MSCs lead to Them as Safer and More Useful Cell Sources for Realizing Various Stem Cell Therapies.
Adipose tissue is an attractive source for somatic stem cell therapy....
30th October, 2009
Foundation of Biomedical Research and Innovation, Department of Somatic Tissue Eng Part A. 2009 Oct 28.
DOI Direct Link
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4 and with mutations in CFH, CFI, CD46, and C3 in patients with atypical haemolytic uraemic syndrome.
Factor H autoantibodies have been reported in ~10% of aHUS patients and...
29th October, 2009
Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, Blood. 2009 Oct 27.
DOI Direct Link
Autophagy induction by the pathogen receptor CD46.
Autophagy is a highly regulated self-degradative mechanism required at a...
20th October, 2009
Universite de Lyon, Lyon, F-69003, France. Cell Host Microbe. 2009 Oct 22;6(4):354-66.
DOI Direct Link

View more research publications.

BioNews Results for CD46

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Influence of Coagulation Factor X on In Vitro and In Vivo Gene Delivery by Adenovirus (Ad) 5, Ad35, and Chimer
Nature:  Oct 27 2009 2:25PM Matching: cd46
Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the So
Nature:  Oct 13 2009 10:33AM Matching: cd46

Clinical Trials:

Clinical Trials Logo
Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme

Patents:

Patents logo
US Patent No.Title
7429486 Recombinant production of mixtures of antibodies
7521056 Stably tethered structures of defined compositions with multiple functions or binding specificities
7527787 Multivalent immunoglobulin-based bioactive assemblies
7531300 Method of diagnosing breast cancer
7534427 Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins

View more patents.

CD46 results (if any) from reagent suppliers

Google CSE Logo
The Abcam catalog
CD46 antibodies. ... CD46 antibody [J4.48]. Flow Cyt, ICC/IF. Mouse monoclonal ... CD46 antibody [MEM-258]. Flow Cyt, WB, IP. Mouse monoclonal ...
http://www.abcam.com/index.html?t=1164&pt=1&c=505...

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CD46 Antibody / CD46 Antibodies
CD46 Antibody / CD46 Antibodies. ... CD46 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-cd46.html...

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CD46 antibody [J4.48] (ab19739) | Abcam
Mouse monoclonal [J4.48] to CD46. CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities
...
http://www.abcam.com/CD46-antibody-J4-48-ab19739.html...

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CD46 (M177) Antibody sc-52647
Indirect FCM analysis of human peripheral blood leukocytes stained with CD46 ( M177), followed by PE-conjugated goat anti-mouse IgG: sc-3738. ...
http://www.scbt.com/datasheet-52647-cd46-m177-antibody.html...

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Purified Anti-human CD46 Antibody Anti-CD46 - BioLegend
Purified Anti-human CD46 Antibody Anti-CD46 - CD46 is a transmembrane protein also known as complement membrane cofactor protein, MCP, and measles virus ...
http://www.biolegend.com/purified-anti-human-cd46-antibody-2...

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CD46 (H-294) Antibody sc-9098
See how others have used CD46 (H-294): sc-9098 antibody and or CD46 (H-294) antibody ... Western blot analysis of CD46 expression in non-transfected 293T:
...
http://www.scbt.com/datasheet-9098-cd46-h-294-antibody.html...

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human CD46 antibody, Phycoerythrin (PE) conjugate
eBioscience technical data sheet for product 12-0469 Phycoerythrin (PE) anti- human CD46 8E2 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_12/12-...

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