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MEN1


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Gene DB Home
Symbol:MEN1
Name(s):multiple endocrine neoplasia I
Type:protein-coding
Organism:Homo sapiens
Synonyms:MEAI, SCG2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18206547 A novel MEN1 gene mutation,R516G, in multiple endocrine neoplasia type 1.
15670192 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
15754732 Observational study of gene-disease association. (HuGE Navigator)
16595707 Observational study of genetic testing. (HuGE Navigator)
17555500 Observational study of genotype prevalence. (HuGE Navigator)
17623761 Observational study of gene-disease association and genetic testing. (HuGE Navigator)
17823710 Observational study of genetic testing. (HuGE Navigator)
17853334 Observational study of gene-disease association. (HuGE Navigator)
15034196 Observational study of gene-disease association. (HuGE Navigator)
11369988 Observational study of genetic testing. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDGlial fibrillary acidic proteinmenin isoform 1--Pubmed
HPRDglial fibrillary acidic proteinMenin--Pubmed
HPRDjun D proto-oncogenemenin isoform 1--Pubmed
HPRDjun D proto-oncogenemenin isoform 1--Pubmed
BINDjun D proto-oncogenemenin isoform 2Menin directly represses JunD-activated transcription-Pubmed
HPRDmothers against decapentaplegic homolog 3menin isoform 1--Pubmed
HPRDmothers against decapentaplegic homolog 3menin isoform 1--Pubmed
HPRDmenin isoform 1nuclear factor of kappa light polypeptide gene enhancer in B-cells 2--Pubmed
HPRDmenin isoform 1nuclear factor of kappa light polypeptide gene enhancer in B-cells 2--Pubmed
HPRDmenin isoform 1replication protein A2, 32kDa--Pubmed

Recent Publications on MEN1:

Pubmed Logo
Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells: possibility of a novel predictive factor for tamoxifen resistance.
Multiple coactivator and corepressor complexes play an important role in...
23rd October, 2009
Division of Endocrinology and Metabolism, Department of Internal Medicine, Breast Cancer Res Treat. 2009 Oct 22.
DOI Direct Link
Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors.
CONTEXT: Multiple endocrine neoplasia type 1 (MEN1) is characterized by...
21st October, 2009
Academic Endocrine Unit, Nuffield Department of Clinical Medicine, J Clin Endocrinol Metab. 2009 Oct;94(10):3640-6. Epub 2009 Jul 21.
DOI Direct Link
Germline mutations in MEN1 and BRCA1 genes in a woman with familial multiple endocrine neoplasia type 1 and inherited breast-ovarian cancer syndromes: a case report.
The simultaneous occurrence of mutations in two different tumor suppressor...
20th October, 2009
Medical Genetics Unit, Department of Clinical Pathophysiology, University Cancer Genet Cytogenet. 2009 Nov;195(1):75-9.
DOI Direct Link
Gastrinomas: a historical perspective.
The journey of gastrinomas had its beginnings in 1955 when Zollinger and...
9th October, 2009
Department of Surgery, Monash University Endocrine Surgery Unit, Alfred J Surg Oncol. 2009 Oct 1;100(5):425-33.
DOI Direct Link
Changes in global gene expression during in vitro decidualization of rat endometrial stromal cells.
During the preimplantation phase of pregnancy the endometrial stroma...
26th September, 2009
Instituto de Biologia y Medicina Experimental, Consejo Nacional de J Cell Physiol. 2009 Sep 24;222(1):127-137.
DOI Direct Link

View more research publications.

BioNews Results for MEN1

: RSS Logo
BioPortfolio Logo
Women and Men Face Off: Who Can Stand the Pain?
Pharma Live:  Oct 19 2009 6:24PM Matching: men1
Campaign to educate men and women about fibromyalgia
News-Medical.Net:  Oct 19 2009 12:18PM Matching: men1
Women and Men Face Off: Who Can Stand the Pain?
Street Insider:  Oct 19 2009 11:19AM Matching: men1
Women and Men Face Off: Who Can Stand the Pain?
NewsBlaze:  Oct 19 2009 11:03AM Matching: men1

Clinical Trials:

Clinical Trials Logo
Study Investigating MEN1 and SDHD in Familial Carcinoid Tumors

Patents:

Patents logo
US Patent No.Title
6471968 Multifunctional nanodevice platform
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6936417 Gene expression in bladder tumors
6964868 Human genes and gene expression products II
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

MEN1 results (if any) from reagent suppliers

Google CSE Logo
MEN1 Antibody (T594)
Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with MEN1 Antibody (T594) (Cat.#AP7415b), which was peroxidase-conjugated to ...
http://www.abgent.com/products/catalog_no/AP7415b_MEN1_Antib...

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Multiple endocrine neoplasia 1 (Men1) polyclonal antibody ...
KLH conjugated synthetic peptide comprised of amino acids 128 - 144 [ SLSRSYFKDRAHIQSLF] of the mouse multiple endocrine neoplasia 1 (Men1) protein.
...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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Rabbit anti-Menin Antibody
Anti-Menin antibody, anti-SCG2 antibody, anti-Men1 ... Neoplasia I (MEN1, LocusLink ID 4221). Antibody was affinity purified using the peptide ...
http://www.natutec.de/pdf_bethyl/A300-106A.pdf...

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Menin (C-19) Antibody sc-8200
Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis. Eur J Cancer. 43: 402-414. ...
http://www.scbt.com/datasheet-8200-menin-c-19-antibody.html...

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Oncoproteins
Multiple endocrine neoplasia 1 (Men1) polyclonal antibody, PAB-10831, $175.00. Multiple endocrine neoplasia 1 (MEN1) polyclonal antibody, PAB-10832, $175.00
...
http://www.orbigen.com/dictionary/cat1054.htm...

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Menin (N-19) Antibody sc-8201
Human, MEN1, 4221, 11q13.1, NM_000244, NM_130799, NM_130800, NM_130801, NM_130802, NM_130803, NM_130804 · O00255 · 145000. Mouse, Men1, 17283, 19 A,
O88559 ...
http://www.scbt.com/datasheet-8201-menin-n-19-antibody.html...

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MB-MN
SAB1400164, Anti-MEN1 antibody produced in mouse New, (polyclonal), IgG fraction of antiserum, human ... MEN1(4221), human, ELISA (c), IF (i), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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