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MFGE8


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Gene DB Home
Symbol:MFGE8
Name(s):milk fat globule-EGF factor 8 protein
Type:protein-coding
Organism:Homo sapiens
Synonyms:BA46, EDIL1, HsT19888, OAcGD3S, SED1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17637751 The trans-activator (TA) isoforms of p63 activate MFGE8 transcription though a p53/p63 motif at -370, which was confirmed by a chromatin immunoprecipitation experiment.
17906662 aggregated medin induced death of aortic smooth muscle cells in vitro. Cells incubated together with medin increased the production of matrix metalloproteinase-2, a protease that degrades elastin and collagen and subsequently weakens the vessel wall.
17679143 Identification of the last 18-19 amino acid residues as constituting the amyloid-promoting region of medin.
15478463 Truncated fragment of medin, the hexapeptide, NFGSVQ can form typical amyloid fibrils.
17420351 Lactadherin) is expressed in normal and atherosclerotic human arteries.
16115445 Might prove useful in the treatment of prolonged ischemia.
12670504 strongly expressed during liver fibrogenesis (O-acetyl disialoganglioside synthase)

Recent Publications on MFGE8:

Pubmed Logo
Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII.
Sepsis, a highly lethal systemic inflammatory syndrome, is associated with...
9th October, 2009
The Feinstein Institute for Medical Research, North Shore University J Immunol. 2009 Nov 1;183(9):5983-90. Epub 2009 Oct 7.
DOI Direct Link
Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human.
Milk fat globule-EGF factor 8 (MFG-E8) is a molecule implicated in...
11th September, 2009
Department of Clinical Laboratory Sciences and Medical Biotechnology, Lupus. 2009 Jul;18(8):676-81.
DOI Direct Link
Efficient identification of phosphatidylserine-binding proteins by ORF phage display.
To efficiently elucidate the biological roles of phosphatidylserine (PS),...
28th July, 2009
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Biochem Biophys Res Commun. 2009 Aug 14;386(1):197-201. Epub 2009 Jun 9.
DOI Direct Link
Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion.
Advancing age induces aortic wall thickening that results from the...
15th July, 2009
Laboratory of Cardiovascular Science, National Institute on Aging-National Circ Res. 2009 Jun 19;104(12):1337-46. Epub 2009 May 14.
DOI Direct Link
Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms.
Carcinogenesis reflects the dynamic interplay of transformed cells and...
8th July, 2009
Department of Surgery and Bioengineering, Advanced Clinical Research J Exp Med. 2009 Jun 8;206(6):1317-26. Epub 2009 May 11.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7531300 Method of diagnosing breast cancer
7371207 Estrogen receptor .alpha. regulated gene expression, related assays and therapeutics
7251568 Methods and compositions for regulating bone and cartilage formation
7229760 mRNA amplification
6706867 DNA array sequence selection

View more patents.

MFGE8 results (if any) from reagent suppliers

Google CSE Logo
MFG Antibody / MFG Antibodies
MFG-E8 (MFG-06) Antibody, sc-8029, mouse IgG1, FL (h), WB, IP, IF, ... MFG-E8 (G -17) Antibody, sc-23999, goat IgG, internal (h), WB, IF, ELISA, h > m, r ...
http://www.scbt.com/table-mfg.html...

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Human MFG-E8 MAb (Clone 278901)
MFG-E8, originally identified as a product of lactating mammary glands, ... This antibody was selected for its ability to detect human MFG-E8 in direct ...
http://www.rndsystems.com/pdf/MAB2767.pdf...

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MFG-E8 (SPM291) Antibody sc-56564
MFG-E8 shRNA (h) Lentiviral Particles, sc-43158-V, 200 µl ... Western blot analysis of MFG-E8 expression in HeLa whole cell lysate. Download ...
http://www.scbt.com/datasheet-56564-mfg-e8-spm291-antibody.h...

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MFG-E8 - R&D Systems
MFG-E8, originally identified as a product of lactating mammary glands, is also secreted by activated macrophages and immature dendritic cells. ...
http://www.rndsystems.com/molecule_detail.aspx?m=2793...

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MFG-E8 (M-135) Antibody sc-33546
See how others have used MFG-E8 (M-135): sc-33546 antibody and or MFG-E8 ... Western blot analysis of MFG-E8 expression in non-transfected: sc-117752 (A) ...
http://www.scbt.com/datasheet-33546-mfg-e8-m-135-antibody.ht...

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mouse MFG-E8 DuoSet
rat anti-mouse MFG-E8 when reconstituted with 1.0 mL of. PBS. After reconstitution, store at 2 - 8° C .... be linearized by plotting the log of the
MFG-E8 ...
http://www.rndsystems.com/pdf/DY2805.pdf...

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MFG-E8 (G-17) Antibody sc-23999
See how others have used MFG-E8 (G-17): sc-23999 antibody and or MFG-E8 (G-17) ... Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by ...
http://www.scbt.com/datasheet-23999-mfg-e8-g-17-antibody.htm...

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