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KITLG


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Symbol:KITLG
Name(s):KIT ligand
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp686F2250, KL-1, Kitl, MGF, SCF, SF, SHEP7
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16905672 Observational study of gene-disease association. (HuGE Navigator)
18083106 These experiments suggest that regulatory changes in Kitlg contribute to natural variation in vertebrate pigmentation, and that similar genetic mechanisms may underlie rapid evolutionary change in fish and humans.
17855052 Early myeloid cells expressing GNNK+ or GNNK-c-KIT show different responses to stem cell factor.
17556598 Distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis.
17687495 SCF can be introduced to rescue cells from the damage caused by certain antineoplastic agents.
17410437 SCF-enhanced proliferation and invasion of KIT-positive colorectal cancer cells is achieved mainly through the PI3K/Akt pathway.
12297464 SCF mRNA is present in K562, HL-60 and CML cells in blast phase
16780589 SCF and Kit are expressed in bronchial biopsies from lung transplant recipients irrespective of the clinical status of the graft; role for these factors in tissue repair following lung transplantation is hypothesised
16709604 stem cell factor and clusterin may have roles in azoospermia
15576295 The SCF is a member of a group of glycoproteins called hematopoietic cytokines (HCs).

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcolony stimulating factor 2 precursorKIT ligand isoform b precursor--Pubmed
HPRDcolony stimulating factor 2 precursorKIT ligand isoform b precursor--Pubmed
HPRDErythropoietin receptorKIT ligand isoform b precursor--Pubmed
HPRDerythropoietin receptor precursorKit ligand--Pubmed
HPRDfms-related tyrosine kinase 3 ligandKIT ligand isoform b precursor--Pubmed
HPRDfms-related tyrosine kinase 3 ligandKIT ligand isoform b precursor--Pubmed
HPRDv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursorKIT ligand isoform b precursor--Pubmed
HPRDv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursorKIT ligand isoform b precursor--Pubmed
HPRDKit ligandHuman phosphatidylinositol 3-kinase delta catalytic subunit mRNA, and translated products--Pubmed
HPRDKIT ligand isoform b precursorPhosphatidylinositol 3 kinase, catalytic subunit, delta--Pubmed

Recent Publications on KITLG:

Pubmed Logo
Characterization of the porcine KIT ligand gene: expression analysis, genomic structure, polymorphism detection and association with coat colour traits.
Kit ligand (KITLG) is the ligand for the type III receptor tyrosine kinase...
24th May, 2008
Andreou & Costi Ltd (Pig Farms), PO Box 40451, 6304 Larnaca, Cyprus. Anim Genet. 2008 Jun;39(3):217-24. Epub 2008 Mar 3.
DOI Direct Link
Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression.
Ovarian germ cell survival is dependent upon the formation of primordial...
30th April, 2008
MRC Human Reproductive Sciences Unit, The Queen's Medical Research Dev Biol. 2008 Feb 1;314(1):189-99. Epub 2007 Dec 3.
DOI Direct Link
A pigment evolution Kitlg.
There is increasing evidence that tumor expressed genes induce immune...
23rd April, 2008
Pigment Cell Melanoma Res. 2008 Apr;21(2):113-4.
DOI Direct Link
Fibroblast growth factor 7 stimulates in vitro growth of oocytes originating from bovine early antral follicles.
Essential factors required for growing oocytes derived from bovine early...
4th April, 2008
Biomechanism and Developmental Symbiosphere Science, Graduate School of Mol Reprod Dev. 2008 Dec;75(12):1736-43.
DOI Direct Link
cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans.
Dramatic pigmentation changes have evolved within most vertebrate groups,...
15th February, 2008
HHMI and Department of Developmental Biology, Stanford University School Cell. 2007 Dec 14;131(6):1179-89.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Interleukin-2 and Stem Cell Factor in Treating Patients With AIDS or AIDS-Related Cancer
Lymphoma Interventions: Drug: aldesleukin;   Drug: recombinant human stem cell factor

Patents:

Patents logo
US Patent No.Title
7081340 Gene expression profiling in biopsied tumor tissues
6994848 Lactobacillus paracasei strain GM-080 for treating allergy related diseases
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles

KITLG results (if any) from reagent suppliers

Google CSE Logo
KITLG Antibody (Center)
Western blot analysis of anti-KITLG Antibody (Center) (Cat.#AP1484c) in 293 cell line ... KITLG(arrow) was detected using the purified Pab (1:60dilution). ...
http://www.abgent.com/catalog_no/AP1484c...

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WH0004254M1 Monoclonal Anti KITLG antibody produced in mouse clone ...
WH0004254M1 Monoclonal Anti-KITLG antibody produced in mouse clone 3E10, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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Abgent Antibodies and Peptides
AP7559b, AARS2 Antibody (C-term), WB, E, H, 2008-10-01. AP1484c, KITLG Antibody (Center), WB, E, H, 2008-10-01. AP7843a, VARS Antibody (N-term), WB, E ...
http://www.abgent.com/docs/special_40off...

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View Cart
KITLG Antibody (N-term) Blocking Peptide, BP1484a, 0.1mg, $42.00, $42.00. Shipping, flat fee, $35.00. Tax will be added to the Total after the order is
...
https://www.abgent.com/store/add_to_cart/BP1484a...

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Specification Sheet
Product Name, Monoclonal Anti-KITLG antibody produced in mouse, ... Sandwich ELISA, Detection limit for recombinant GST tagged KITLG is approximately ...
http://www.sigmaaldrich.com/catalog/search/SpecificationShee...

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SCF Antibody / SCF Antibodies
Search. Advanced Search. Browse our Catalog, Protein A, G PLUS or L-Agarose, Alexa Fluor® Conjugated Primary Antibodies, Tumor Suppressors/Apoptosis ...
http://www.scbt.com/table-scf.html...

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K0131 Monoclonal Anti c kit SCF Receptor antibody produced in ...
KITLG(4254). shipped in. dry ice. storage temp. −20°C. References. Reference. Blechman, J.M., et al., The fourth immunoglobulin domain of the stem cell ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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Akt
FGF7 · KITLG · VEGFC. Receptor Tyrosine Kinases. Gene Symbol. ALK · EPHB1 · INSR · AXL · EPHB2 · INSRR · CREBBP · EPHB3 · KDR · CSF1R · EPHB4 · KIT ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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S2806 Monoclonal Anti Stem Cell Factor antibody produced in mouse ...
KITLG(4254). storage temp. −20°C. Safety. WGK Germany. 3. Related Categories .. . Antibodies to Cytokines and Growth Factors > Antibodies to Hematopoietic ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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Kitl kit ligand
Kitl; CLO; CON; CONTRASTED; GB; KITL; KITLG; MGF; SCF; SF; SL; SLF; STEEL. Other Designations. Steel factor; cloud gray; grizzle-belly; mast cell growth ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

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