Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16905672 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18083106 |
These experiments suggest that regulatory changes in Kitlg contribute to natural variation in vertebrate pigmentation, and that similar genetic mechanisms may underlie rapid evolutionary change in fish and humans. |
| 17855052 |
Early myeloid cells expressing GNNK+ or GNNK-c-KIT show different responses to stem cell factor. |
| 17556598 |
Distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis. |
| 17687495 |
SCF can be introduced to rescue cells from the damage caused by certain antineoplastic agents. |
| 17410437 |
SCF-enhanced proliferation and invasion of KIT-positive colorectal cancer cells is achieved mainly through the PI3K/Akt pathway. |
| 12297464 |
SCF mRNA is present in K562, HL-60 and CML cells in blast phase |
| 16780589 |
SCF and Kit are expressed in bronchial biopsies from lung transplant recipients irrespective of the clinical status of the graft; role for these factors in tissue repair following lung transplantation is hypothesised |
| 16709604 |
stem cell factor and clusterin may have roles in azoospermia |
| 15576295 |
The SCF is a member of a group of glycoproteins called hematopoietic cytokines (HCs). |
| 15781331 |
The effect of THPO on HuMCs in the presence of rhSCF varies, depending on the relative concentration of each growth factor, while THPO alone or in combination with rhSCF supports a unique population of CD117low/CD110+ HuMCs. |
| 15140230 |
the accentuated expression of SCF in lesional skin plays an important role in the mechanism involved in the epidermal hyperpigmentation of lentigo senilis |
| 12637332 |
SCF up-regulates Bcl-2 and Bcl-X L in erythroid precursors and exogenous expression of these proteins protects erythroblasts from caspase activation and death induced by chemotherapeutic agents. |
| 15475566 |
C-terminal valine defines a specific endoplasmic reticulum export signal in Kitl |
| 16015044 |
KIT expression is a hallmark of oncocytoma and chromophobe renal cell carcinoma. |
| 11905054 |
important factor for the growth and activation of nasal epithelial mast cells |
| 12062186 |
Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas. |
| 15504546 |
When SCF was added with TNF-alpha, cell growth inhibition was reduced and the apoptotic cells decreased. The activations of caspase 3 and caspase 8 were almost completely blocked by SCF while CDK6 and the FLICE-inhibitory protein (FLIP) were increased. |
| 12429808 |
the SCF-c-kit system, possibly with the contribution of mast cells, may have a growth-regulating role in the normal pancreas, which is altered during malignant transformation. |
| 14985355 |
SCF dose-dependently promoted survival, migration, and capillary tube formation of HUVEC cells. Akt and Erk1/2 should promote survival and capillary tube formation of these endothelial cells at a locus downstream to stem cell factor/c-kit signaling |
| 15378028 |
HMGA1 positively regulates the human KL promoter in breast and ovarian cancer cells |
| 15474101 |
The expression of SCF and its receptor in ovarian tissue from fetuses and women suggests a possible role of SCF in growth initiation of human primordial follicles. |
| 15308671 |
c-Kit makes both kinase-independent and -dependent contributions to the proliferative synergy induced by SCF in combination with GM-CSF |
| 15866728 |
The SCF gene was cloned into baculovirus transfer vector pVL1392 under the control of polyhedrin promoter and expressed in the Sf9 cells (Spodoptera frugiperda). |
| 12393703 |
stem cell factor has "late" effects on fetal hemoglobin modulation during erythropoiesis, related to the expression pattern of CD117. |
| 12829027 |
protein CBP/p300 was shown to be essential for EPO- and SCF-mediated STAT5 transactivation |
| 12666065 |
SCF correlated negatively with creatinine clearance & positively with glomerular & interstitial CD68+ cells & collagen III. SCF was shown in the vicinity of alpha-SMA+ cells. This shows potential involvement of SCF/c-kit in crescentic glomerulonephritis. |
| 15337769 |
induction of Slug by autocrine production of SCF and c-Kit activation plays a key role in chemoresistance of malignant mesothelioma |
| 12445210 |
several inflammatory cytokines (T helper 1 and 2) and vasoactive intestinal peptide from mast cells and nerve endings are capable of inducing stem cell factor production from epidermal keratinocytes in atopic dermatitis. |
| 12753403 |
Kit-ligand has a role in melanocyte development and epidermal homeostasis [review] |
| 16213778 |
SCF/c-Kit interactions are likely to be involved in mediating islet cell differentiation and proliferation during human fetal pancreatic development, and that phosphorylated Akt may have a role downstream of SCF/c-Kit signaling. |
| 17115933 |
antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation in leukemic cells |
| 17289809 |
A potential role of the c-Kit/mbKitL interaction in pathological settings is sustained by the expression of the membrane-bound KitL on endothelial cells lining intraplaque neovessels. |
| 12002675 |
Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. |
| 14691917 |
Gastrointestinal stromal tumors carrying 1530ins6 occur exclusively in the intestinal location, and a great majority of these tumors follow a malignant course |
| 16181409 |
Neuroprotective role for SCF in cortical neurons, an effect mediated by Akt and ERK, as well as NFkappaB-mediated gene transcription. SCF represents a novel therapeutic target in the treatment of neurodegenerative disease. |
| 17191042 |
In patients with urticaria pigmentosa, the mutation of the c-kit Asp-816-Val was detected in 38% of the adults and 25% of the children. |
| 12123753 |
There was a powerful and statistically significant synergy for release of IL-8, both at the mRNA level and protein level between adenosine A(2b) receptor agonists and stem cell factor (SCF). |
| 14628073 |
long-term exposure of primitive human hematopoietic cells to elevated levels of human IL-3, GM-CSF and SF in vivo may deleteriously affect the stem cell compartment, while expanding terminal myelopoiesis. |
| 15217825 |
only Kit ligand stimulated phosphorylation of signal transducer and activator of transcription 5 |
| 15355893 |
Increased stem cell factor levels are associated with tumorigenesis in neurofibromatosis type 1 |
| 15504551 |
HGF maintains the hematopoietic microenvironment through stimulating proliferation and adhesion to the extracellular matrix and promoting hematopoiesis through inducing constitutive production of IL-11, SDF-1 alpha, and SCF by stromal cells themselves |
| 15526978 |
Coculture with murine embryos enhanced the gene expression of SCF in human ovarian granulosa tumor cells and enhanced murine embryo development. |
| 15728521 |
Serum levels of early hemopoietic cytokine stem cell factor (SCF) correlate with disease activity in Langerhans cell histiocytosis and are relatively higher in patients with bone lesions. |
| 15526160 |
stem cell factor receptor/c-Kit has a role in signal transduction [review] |
| 12556557 |
constitutively activated Bcr-Abl kinase pathways in primitive CML progenitors cooperate with growth factors producing a growth response, and, disrupt the normally required synergistic interactions between KL and other cytokines to achieve activation |
| 14654075 |
findings of co-expression of KIT and/or FMS with their respective ligands implies these receptors might contribute to leukemogenesis in some patients with AML through autocrine, paracrine, or intracrine interactive stimulation. |
| 16905672 |
Our data indicate that the KIT/KITLG system may be involved in a low sperm count trait in humans. |
| 17175329 |
influence of the extent of liver resection on levels and kinetics of serum growth factors. |
| 14662725 |
"Stem cell factor (SCF) also termed Kit ligand, steel factor or mast cell growth factor is the ligand of the c-kit proto-oncogene product." P. 75 |
| 15145934 |
acquisition of autonomous growth during uveal melanoma progression may involve the SCF/c-Kit axis |
| 16479403 |
Stem cell factor is an important cytokine in neurofibromatosis type 1 skin, but that additional (growth) factors and/or genetic mechanisms are needed to induce NF1-specific CALM hyperpigmentation. |
| 16616334 |
SCF/c-Kit pathway plays an important role in tumor- and normal host cell-induced angiogenesis within the brain |
| 16647379 |
Mutations in the coding regions of the KITLG gene appear not to be a common cause of 46,XX spontaneous premature ovarian failure in North American women. |
