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ASCL1


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Symbol:ASCL1
Name(s):achaete-scute complex homolog 1 (Drosophila)
Type:protein-coding
Organism:Homo sapiens
Synonyms:ASH1, HASH1, MASH1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15240857 Observational study of gene-disease association. (HuGE Navigator)
16021468 Observational study of gene-disease association. (HuGE Navigator)
16899352 Observational study of gene-disease association. (HuGE Navigator)
17507989 Knockdown of ASH1 gene in lung neoplasm cells in vitro suppressed growth by increasing apoptosis.
11948117 HASH1 mRNA expression levels in SCLC clinical samples were 1,000-fold higher than in the NSCLC samples, and this method could contribute to diagnosis based on molecular profiling of tumors.
14668716 HASH1 appears to be important in the endocrine phenotype of medullary thyroid carcinoma (MTC) tumors and may serve as a molecular target for the treatment of patients with MTC.
15272537 the hASH1 mRNA level might represent a useful tool for distinguishing esthesioneuroblastoma from poorly differentiated tumors of the sinonasal region
16021468 The present genetic data may thus suggest that polyglutamine length polymorphisms in ASCL1 could influence predispositions to PD through the fine-tuning of LC integrity.
16029117 RaF-1 activation causes cessation of hASH-1 expression
15701827 Up-Regulation of ASCL1 is associated with gastrointestinal neuroendocrine carcinomas

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDachaete-scute complex homolog-like 1bone morphogenetic protein 2 preproprotein--Pubmed
HPRDachaete-scute complex homolog-like 1bone morphogenetic protein 2 preproprotein--Pubmed
HPRDachaete-scute complex homolog-like 1transcription factor 4 isoform b--Pubmed
HPRDachaete-scute complex homolog-like 1transcription factor 4 isoform b--Pubmed
HPRDachaete-scute complex homolog-like 1myocyte enhancer factor 2A--Pubmed
HPRDachaete-scute complex homolog-like 1myocyte enhancer factor 2A--Pubmed

Recent Publications on ASCL1:

Pubmed Logo
BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways.
Induction of the sympathetic nervous system (SNS) from its neural crest...
2nd October, 2009
Department of Cell and Molecular Biology, Tulane University, New Orleans, Development. 2009 Nov;136(21):3575-84. Epub 2009 Sep 30.
DOI Direct Link
Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.
Monoaminergic neurons include the physiologically important central...
25th September, 2009
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, Development. 2009 Jul;136(14):2477-85.
DOI Direct Link
Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.
Obtaining the diversity of interneuron subtypes in their appropriate...
25th September, 2009
Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Development. 2009 Jul;136(14):2329-34.
DOI Direct Link
Cholinergic switch associated with morphological differentiation in neuroblastoma.
The morphology of malignant cells distinguishes between undifferentiated,...
22nd September, 2009
INSERM U830, Institut Curie, Genetique et biologie des Cancers, Paris, J Pathol. 2009 Aug 11.
DOI Direct Link
MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype.
BACKGROUND: Carcinoid cancers are the most common neuroendocrine (NE)...
22nd September, 2009
Endocrine Surgery Research Laboratories, Department of Surgery, University J Surg Res. 2009 Jun 21.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7531300 Method of diagnosing breast cancer
7323165 Production of pancreatic islet cells and delivery of insulin
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

ASCL1 results (if any) from reagent suppliers

Google CSE Logo
ASCL1 (N-17) Antibody sc-13219
ASCL1 shRNA (h) Lentiviral Particles, sc-37692-V, 200 µl ... Western blot analysis of ASCL1 expression in non-transfected 293T: sc-117752 (A), human ASCL1
...
http://www.scbt.com/datasheet-13219-ASCL1-n-17-antibody.html...

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ASCL1 (Achaete-scute homolog 1) Antibody (L68)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/products/catalog_no/AP2746d_ASCL1_Acha...

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Achaete-Scute Antibody / Achaete-Scute Antibodies
ASCL1 (C-16) Antibody, sc-13222, goat IgG, C-terminus (h), WB, IP, IF, ELISA, m, r, h ... ASCL1 (N-17) Antibody, sc-13219, goat IgG, N-terminus (h), WB, IP, ...
http://www.scbt.com/table-achaete-scute.html...

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Layout 1 (Page 1)
Ascl1 antibody. (ab38557). • BLBP antibody. (ab32423) ... Neurogenin2, Mash1 ( Ascl1), NeuroD1. • Molecular details differ between the two neurogenic regions
...
http://www.abcam.com/ps/pdf/neuroscience/adult_neurogenesis....

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ASCL1 siRNA (h) sc-37692
Click here for details. suitable control antibody: ASCL1 (N-17): sc-13219; sqRT- PCR Primer also available: ASCL1 (h)-PR: sc-37692-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-37692-ASCL1-sirna-h.html...

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MASH1 Gene - Achaete-scute complex-like 1 (Gene ASCL1)
Details of the MASH1 gene structure and function along with references and related research products.
http://www.sigmaaldrich.com/life-science/your-favorite-gene-...

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HES6 antibody (ab66461) | Abcam
It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/ MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription ...
http://www.abcam.com/hes6-antibody-ab66461.html...

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