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nct
| Symbol: | nct | | Name(s): | nicastrin | | Type: | protein-coding | | Organism: | Drosophila melanogaster | | Synonyms: | CG7012, Nic, S5A, agro | | Links: |
Pubmed,
Entrez Gene,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16675392 |
Presenilin and nicastrin prevent tau toxicity by modulating the PI3K/Akt/GSK3beta phosphorylation pathway, whereas aph-1 regulates aPKC/PAR-1 activities |
| 16145661 |
Nicastrin is essential to early photoreceptor neuron development |
| 16103123 |
presenilin, nicastrin, APH-1, and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes |
| 12660785 |
Co-expression of Drosophila Pen-2 with Aph-1 and nicastrin increases the formation of Psn fragments as well as gamma-secretase activity |
| 15644323 |
the proper assembly of the Aph-1.nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and Aph-1 functions as a stabilizing scaffold in the assembly of this complex |
| 12771124 |
Aph-1 and Nct may form a subcomplex that stabilizes the Psn holoprotein at an early step in gamma-secretase assembly. |
nct results (if any) from reagent suppliers | 
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