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MLLT4
| Symbol: | MLLT4 | | Name(s): | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AF-6, AF6, AFADIN, FLJ34371, RP3-431P23.3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17491594 |
c-Src is recruited by AF-6 to cell-cell contact sites, suggesting that c-Src is regulated by a PDZ protein in special cellular locations. |
| 18052198 |
two distal surfaces of the AF-6 PDZ domain respond differently to peptide binding; distal surface 1 changes in millisecond dynamics, whereas distal surface 2 undergoes structural rearrangement |
| 17967423 |
AF6 protein is important for spreading of Herpes simplex virus 1 in epithelial cells |
| 11956217 |
RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. |
| 16819513 |
Loss of afadin is associated with breast cancer |
| 15684424 |
Results report the solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr. |
| 17013812 |
AF6/s-afadin is a candidate for mediating control of cellular growth processes by regulated translocation to the nucleus. |
| 12808105 |
Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain |
| 16051602 |
AF6 negatively regulates Rap1-induced cell adhesion. |
| 9722616 |
This paper deals with AF-6 in mouse, rat, and cow. | →View more information from publications. |
Recent Publications on MLLT4: |  |
New insights to the MLL recombinome of acute leukemias.
Chromosomal rearrangements of the human MLL gene are associated with... | 22nd September, 2009
| Diagnostic Center of Acute Leukemia, Institute of Pharmaceutical Biology,
| Leukemia. 2009 Aug;23(8):1490-9. Epub 2009 Mar 5.
DOI Direct Link |
Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia.
Pediatric de novo acute myeloid leukemia (AML) is an aggressive malignancy... | 27th August, 2009
| Department of Pathology, St. Jude Children's Research Hospital, 262 Danny
| Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12944-9. Epub 2009 Jul 27.
DOI Direct Link |
Regulation of c-Src by binding to the PDZ domain of AF-6.
c-Src is a tightly regulated non-receptor tyrosine kinase. We describe the... | 7th March, 2008
| Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
| EMBO J. 2007 Jun 6;26(11):2633-44. Epub 2007 May 10.
DOI Direct Link |
Interesting structural and dynamical behaviors exhibited by the AF-6 PDZ domain upon Bcr peptide binding.
PDZ (postsynaptic density-95, disks large, zonula occludens-1) domains are... | 28th February, 2008
| Hefei National Laboratory for Physical Sciences at Microscale, University
| Biochemistry. 2007 Dec 25;46(51):15042-53. Epub 2007 Dec 4.
DOI Direct Link |
Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1.
AF6 and its rat homologue afadin are multidomain proteins localized at... | 5th February, 2008
| Institute of Medical Virology, University of Zurich, Gloriastrasse 30,
| FEBS Lett. 2007 Nov 27;581(28):5349-54. Epub 2007 Oct 29.
DOI Direct Link |
→View more research publications. |
MLLT4 results (if any) from reagent suppliers | 
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Afadin (MLLT4) Antibody (Center A1152)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human MLLT4. Other Names:
...
http://www.abgent.com/products/catalog_no/AP6191d_Afadin_MLL...
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AF-6 (B-5) Antibody sc-74433
... Protein Accession #, OMIM™ Number. Human, MLLT4, 4301, 6q27, NM_001040000, NM_001040001, NM_005936 · P55196 · 159559. Mouse, Mllt4, 17356, 17 A1, Q9QZQ1
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http://www.scbt.com/datasheet-74433-af-6-b-5-antibody.html...
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Abgent Antibodies and Peptides
AP6191d, MLLT4 Antibody (Center A1152), H. AP6191c, MLLT4 Antibody (C-term C1725 ), H. AP6191b, MLLT4 Antibody (N-term), H. AP2522a, MLP Antibody (N-term), H ...
http://www.abgent.com/docs/product_investigation...
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AF-6 (35) Antibody sc-135823
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, MLLT4, 4301, 6q27, P55196 ...
http://www.scbt.com/datasheet-135823-af-6-35-antibody.html...
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Abgent - Chromatin and Regulation Antibodies - Chromatin_regulation
AP6191c, Afadin (MLLT4) Antibody (C-term C1725), E, H. AP6191a, Afadin (MLLT4) Antibody (C-term) ... AP6191d, Afadin (MLLT4) Antibody (Center A1152), E, H ...
http://www.abgent.com/products/category/nuclear_signaling/ch...
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Oncoproteins
Myeloid/lymphoid or mixed-lineage leukemia translocated to 4 (MLLT4) polyclonal antibody, PAB-10854, $175.00. Myeloid/lymphoid or mixed-lineage leukemia ...
http://www.orbigen.com/dictionary/cat1054.htm...
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MB-MN
AV34225, Anti-MLLT4 antibody produced in rabbit, (polyclonal), IgG fraction of antiserum, human ... MLLT4(4301), human, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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