Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17697361 |
TauCl differentially inhibits the expression of MMP-1 and MMP-13in human synoviocytes. |
| 18259971 |
Alveolar macrophage matrix metalloproteinase 1 and 12 may have a role in the lung structural changes leading to the development of emphysema. |
| 18027871 |
upregulation of MT1-MMP by GM-CSF must only occur in cells directly involved in tubule formation |
| 18097620 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18276095 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18164995 |
Investigation of cellular responses to experimental phonation may provide insight into how matrix metalloproteinases and other extracellular matrices contribute to maintenance of the vocal fold and development of pathology. |
| 18060744 |
IL-1beta and MIF cytokine network induce MMP-1 and contribute to the loss of interstitial collagen in skin photoaging |
| 15718477 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15767330 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15832405 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15866608 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15879464 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15939478 |
Observational study of genetic testing. (HuGE Navigator) |
| 15944607 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15955221 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15957163 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16080875 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16202315 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16210545 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16214204 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16256416 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16267613 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16278009 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16301860 |
Meta-analysis and HuGE review of gene-disease association, gene-gene interaction, and healthcare-related. (HuGE Navigator) |
| 16302919 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16311244 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 16353148 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16356191 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16405530 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16424284 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16532917 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16538639 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16638593 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16676616 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16739355 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16767672 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16774538 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16899023 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16937230 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16945025 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16990034 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17000679 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17033924 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17077200 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17125518 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17145822 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17178858 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17311017 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17352267 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17363400 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17363767 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17373931 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17383306 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17441888 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 17473191 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17537400 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17589947 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17599818 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17607721 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17765638 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17893005 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17901377 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17919326 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17980059 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17986285 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17996495 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18006768 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18025848 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18028894 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18035073 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18178580 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11489811 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11528521 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11546917 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11586041 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11691799 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 11824952 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11875051 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12225803 |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
| 12229968 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12364729 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 12432557 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 12473595 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12515907 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12572877 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12622858 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12845675 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12969782 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14499230 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14626631 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14659851 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14986114 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15127970 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15142265 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15149160 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15194213 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15200479 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15257748 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15274394 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15288468 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15312099 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15319295 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15337261 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15476622 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15528217 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15612581 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15617836 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15661214 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 15701845 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17502998 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18212480 |
Melittin did not affect MMP1 secretion by rheumatoid arthritic fibroblasts. |
| 17986285 |
results suggest that the MMP-1 promoter polymorphism might be linked to susceptibility for bladder cancer. |
| 17949787 |
Elevated expression of MMP-1 and urokinase plasminogen activator can be used to identify patients with a worse prognosis in skull base chordoma. |
| 18025848 |
the 2G allele of the MMP-1 promoter polymorphism might not modify the risk of prostate cancer development and might not be used as a putative marker to predict the potential of metastasis in this cancer type, at least in the Turkish population |
| 18028894 |
Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in idiopathic dilated cardiomyopathy patients, was significantly different from that in healthy controls. |
| 18025061 |
No difference exists in gene expression of MMPs in ascending aorta and AV between patients with BAV and TAV. |
| 17765638 |
Finds no association between the MMP-1 promotor haplotype -1607 1G/2G and mital valve prolapse. |
| 18030675 |
Increased transcript and active MMP1 levels in the most severely affected children, who carried a known SNP (1G/2G) in the MMP1 promoter suggesting increased degradation by metalloproteinases. |
| 17921324 |
IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation. |
| 17990358 |
MMP-1 and TNF-alpha correlate well with the severity of the disease, and therefore, can be used clinically as biological markers to judge the severity of ulcerative colitis. |
| 17919326 |
this report suggests a crucial impact of the MMP-1 2G allele in the early onset oral squamous cell carcinoma. |
| 18089791 |
mmp1 inhibition mediates extracellular matrix lysis at cell-matrix adhesions induces the establishment of cell polarity, which facilitates cell-matrix adhesion turnover and subsequent cell migration in tumor cells. |
| 17316652 |
enhanced cell cycle entry, increased MAPK signaling, and downregulated MMP-1 and MMP-3 seen in diabetic arterial vasculature could have a role in progressive atherosclerosis and postangioplasty restenosis in diabetic patients |
| 17714581 |
Type 2 diabetes LDL lipoproteins increasin adhesion molecules by promoting increased expression of MMP1. |
| 18006830 |
targeted inhibition of MMP-1, a single effector of the Raf/MEK/ERK signaling cascade, prevents the progression of melanoma from a primary to metastatic tumor |
| 17599818 |
The genetic variation in MMP-1 may represent a marker for the increased risk of nasopharyngeal carcinoma. |
| 16912186 |
MMP-1 expression was confirmed by using specific PI3K inhibitors in metastatic prostatic cancr. |
| 17611984 |
The MMP-1 stimulatory effect of the eta isoform explains its correlation with MMP-1 levels seen in these samples from patients with inflammed joints. |
| 17502998 |
MMP-1 -1607 1G/1G genotype and MMP-1 1G-MMP-3 6A haplotype may play protective role in the development of adult astrocytoma in northern Chinese |
| 17709546 |
uPA plays a major role in inducing MMP-1 production in activated human monocytes, which is mediated by a plasmin-dependent mechanism involving signaling through the annexin A2 heterotetramer. |
| 17508023 |
Heat-shock-induced MMP-1 expression is mediated by activation of TRPV1 and is dependent on a calcium-dependent signaling process in human epidermal keratinocytes. |
| 17033924 |
No convincing evidence was found to support the association of MMP1 SNPs with increased breast cancer risk or survival. |
| 17475625 |
H. pylori effects on host epithelial MMP-1 expression via ERK, with p38 playing a potential regulatory role |
| 17625450 |
MMP-1 produced from melanoma cells may play a role in tumor progression by both degrading matrix proteins and generating active growth factors such as TGF-beta in vivo |
| 17109104 |
High levels of MMP-1 in tumour and mucosa as well as MMP-2 in plasma may be correlated to risk of developing distant metastases. |
| 12787920 |
These data provide evidence that tissue factor pathway inhibitor-2 does not bind to matrix metalloproteinases-2, -9 or -1, or regulate matrix metalloproteinase-1, in the extracellular matrix. |
| 16311244 |
matrix metalloproteinase 1, 3 and 12 haplotypes may associated with development of lung cancer, particularly among never smokers and men |
| 12050187 |
Oxidized low-density and high-density lipoproteins regulate the production by activated monocytes |
| 15274394 |
The presence of the MMP1-2G and MMP3-6A alleles seemed to be associated with decreased risk of head and neck squamous cell carcinoma but mainly when they were carried by the same haplotype. |
| 16453302 |
demonstrate a novel role for CCAAT/enhancer binding protein (C/EBP), beta in interleukin-1beta-induced connective tissue disease and define a new nuclear target for the Extracellular Signal-Regulated MAP Kinases pathway in MMP-1 gene activation |
| 16767840 |
Matrix metalloproteinase-I genetic variants may play a role in myocardial infarction |
| 12706853 |
MMP1 has a role in tumor invasion [review] |
| 12969782 |
reported association between the matrix metalloproteinase 1 promoter polymorphism and ovarian cancer risk was not supported by our |
| 14982353 |
polymorphism in the promoter region may be associated with early implant failure |
| 15534109 |
MMP1 single nucleotide polymorphism does not appear to have a role in the progression of chondrosarcoma |
| 14679206 |
results suggest that matrix metalloproteinase-1 can stimulate dephosphorylation of Akt protein and neuronal death through a non-proteolytic mechanism that involves changes in integrin alpha2beta1 signaling |
| 12517806 |
viral LMP1 and Zta proteins regulate the expression and activity of MMP-1; first evidence that viral proteins are capable of regulating MMP-1 and clues for the role of EBV in nasopharyngeal carcinoma progression |
| 16273295 |
These results demonstrate that UVB-irradiated keratinocytes promoted MMP-1 production in UVA-irradiated fibroblasts in a paracrine manner while IL-1Ra reduced MMP-1 production through inhibiting c-Jun mRNA expression. |
| 16410344 |
Coordinated down-regulation of collagen & TIMP-1 and up-regulation of MMP-1 occurs in fibroblasts exposed to proteasome inhibitors, indicating the proteasome's role in fibrosis and extracellular matrix remodeling. |
| 16580524 |
C-reactive protein augmented MMP-1 and -10 messenger ribonucleic acid expression in vascular endothelial cells. Might provide a link between inflammation and plaque vulnerability. |
| 16921111 |
MMP1 plays a pathogenic role in human emphysema. |
| 16921115 |
Individuals with the 2G insertion polymorphsim who smoke may be predisposed to enhanced MMP-1 expression in the lung, contributing to the development of COPD. |
| 12873541 |
Patients with deteriorating heart failure have increased expression of TIMP1 and MMP1 mRNA. Correlation with pro-inflammatory cytokines suggests common pathways of regulation and potential activation by IL-6 and IL1-beta. |
| 15737206 |
essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1. |
| 15288123 |
Beta-carotene suppresseds UVA-induction of MMP-1. |
| 15288468 |
No general associations of MMP-1 and MMP-3 genes to primary sclerosing cholangitis(PSC) or ulcerative colitis(UC) among Norwegians, but specific alleles were associated to subsets of PSC patients with UC and cholangiocarcinoma. |
| 16386110 |
expression of MMP-1 was repressed significantly and consistently at the RNA, the protein, and the secretory levels in uninfected newborns of HIV-1 infected mothers as compared to newborns of non-infected mothers |
| 15654517 |
gene expression regulation in Lyme disease |
| 15654971 |
the level of matrix metalloproteinase (MMP)-1 mRNA expression was markedly increased in fibroblasts receiving keratinocyte releasable stratifin |
| 15955221 |
MMP-1 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases. |
| 12393408 |
MMP1 may play a pivotal role in the formation of capillarylike tubular structures in a collagen-containing fibrin matrix in vitro and may be involved in angiogenesis in a fibrinous exudate in vivo. |
| 15864312 |
MMP-1 is a candidate marker that may be useful for identification of breast lesions that can develop into cancer. |
| 12034345 |
destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells. |
| 16681691 |
MMP-1 showed only slight variation between the dilated, ischaemic and valvular cardiomyopathy. |
| 17441888 |
results indicate that MMP-1-1607 bp polymorphism shows ethnic diversity, and that the hypothesis that this polymorphism is associated with epithelial ovarian cancer is not supported by this study in a Korean population |
| 11918701 |
Membrane type 1 matrix metalloproteinase regulates cellular invasiveness and survival in cutaneous epidermal cells. |
| 12837283 |
MMP1 is a senescence-associated gene in normal human oral keratinocytes. |
| 15804950 |
The expression of MMP-1 was significantly increased in the Crohn's disease |
| 12005449 |
A newly identified single nucleotide polymorphism at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was studied. |
| 12032154 |
Accessory elements, flanking DNA sequence, and promoter context play key roles in determining the efficacy of insulin and phorbol ester signaling through the enzyme motifs |
| 16076963 |
MMP-1 expression by latanoprost requires prior up-regulation of COX-2 |
| 16877347 |
These results suggest that CXCL12/CXCR4 interaction transduces the two signaling pathways to promote Natural Killer-cell invasion, which stimulates pericellular degradation of extracellular matrix proteins by membrane-associated MMP-1. |
| 17434489 |
Accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha. |
| 14581488 |
MIF is involved in the up-regulation of UVA-induced MMP-1 in dermal fibroblasts through PKC-, PKA-, Src family tyrosine kinase-, MAPK-, c-Jun-, and AP-1-dependent pathways. |
| 17125518 |
These data show a relationship betweeen MMP1 polymorphism and risk of small adenomas associated with colorectal neoplasms. |
| 14550555 |
EWS-ER81 and EWS-Fli-1 interact with and thereby activate the MMP-1 promoter, which is potentiated by the cofactor p300 and the proto-oncoprotein c-Jun. |
| 15383690 |
Intra-articular hyaluronic acid may rescue inflamed joints from bone and cartilage destruction by reducing the production of MMP-1. |
| 15707890 |
MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion. |
| 15467742 |
overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80% |
| 16278291 |
overexpression of SphK1 up-regulated MMP1 protein, MMP1 mRNA, and MMP1 promoter activity, and this action of SphK1 required activation of the ERK1/2-Ets1 and NF-kappaB pathways |
| 16359987 |
The active MMP-1 and MMP-9 plasma levels were found to vary in the menstrual cycle |
| 12009332 |
Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells |
| 15930517 |
results demonstrate that EPA can inhibit UV-induced MMP-1 expression by inhibiting the MEK1/ERK/c-Fos and SEK1/JNK/c-Jun pathways |
| 11779859 |
Thus, MT1-MMP oligomerization through the hemopexin, transmembrane, and cytoplasmic domains controls its catalytic activity. |
| 12845675 |
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with renal cell carcinoma |
| 15291299 |
matrix metalloproteinase-1 (MMP-1) has been suggested to be involved in skin photodamage. |
| 12145314 |
Results demonstrate that generation of the 44-kDa membrane type-1 matrix metalloproteinase (MT1-MMP) autolysis product regulates collagenolytic activity and subsequent invasive potential. |
| 11751876 |
members of the forkhead family of transcription factors play a role in regulation of the collagenase promoter and increased activity of forkhead transcription factors underlie the increase in collagenase expression observed during replicative senescence |
| 11934016 |
in the late healing period of radiation-impaired wounds, increased expression of MMP1 may be related to overdegradation of matrixes and difficulty in granulation tissue formation |
| 14669348 |
Overexpressed in ulcerative colitis and serve as biological markers. |
| 15701845 |
Polymorphism in the promoter region of the MMP-1 is associated with colorectal cancer |
| 15855654 |
These observations strongly suggest that intracellular association of MMP-1 to mitochondria and nuclei confers resistance to apoptosis and may explain the well-known association of this enzyme with tumor cell survival and spreading. |
| 16714289 |
Pge2 abolished the MEKK1-induced MMP-1 promoter luciferase activity. |
| 16850107 |
Significantly higher mRNA expression of MMP-1 was found in brain-seeking 231-breast cancer clones in comparison to bone-seeking and parental cells. |
| 16967187 |
All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II. |
| 17050530 |
analysis of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1 |
| 12692352 |
Gene expression for MMP-1 after UVA1 irradiation was induced in all fibroblasts, but the induction rate was greater in systemic sclerosis fibroblasts than in normal ones. |
| 15308634 |
PHGPx modulates the induction of MMP-1 and collagenase. |
| 15319295 |
Polymorphisms in MMP-1 is associated with renal cell carcinoma |
| 15610507 |
heat shock-induced expression of MMP-1 and MMP-3 is mediated via an IL-6-dependent autocrine mechanism |
| 15965045 |
in affected tissues the oxidative stress-elicited overexpression of MMP1, and probably other matrix metalloproteinases involved in cytoskeleton remodeling, may play an important role in the pathogenesis |
| 16569638 |
matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs |
| 17009408 |
Excessive expression of MMP-1 and TIMP-1 in the diseased colonic mucosa causes excessive hydrolysis of the extracellular matrix (ECM) and ulceration in ulcerative colitis (UC) patients. |
| 17311017 |
colorectal carcinoma patients with the 2G/2G genotype for the MMP-1 single nucleotide polymorphisms had significantly better 5-year survival compared to patients with a 1G allele (P<0.05). |
| 12788533 |
Hypoxia may be responsible for delayed wound healing by inducing an increase of MMP-1 synthesis. |
| 12651627 |
expression and regulation by intestinal myofibroblasts in inflammatory bowel disease |
| 12784383 |
MMP-1 epitope increased interleukin 4 (IL-4) production of rheumatoid arthritis lymphocytes and decreased IL-4 production by control lymphocytes |
| 14962105 |
general role for elevated MT1-MMP in promoting both the selective invasion and increased growth of malignant melanoma in vivo. |
| 15459390 |
results show that activated collagenase (MMP-1) moves processively on the collagen fibril; the mechanism of movement is a biased diffusion with the bias component dependent on the proteolysis of its substrate, not adenosine triphosphate (ATP) hydrolysis |
| 12225803 |
Association of a polymorphism of the matrix metalloproteinase-1 gene with bone mineral density.Bone density for the distal radius was significantly lower in postmenopausal women with the GG/GG genotype. |
| 16210018 |
In both endometrial glands and corresponding endometriotic epithelium, the distribution of MMP-1 is correlated with estrogen receptor beta. |
| 15200479 |
2G genotype in MMP-1 promoter was associated with the risk of oral squamous cell carcinoma |
| 12071839 |
Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts. |
| 14730602 |
Rb protein negatively regulates p38 activation, leading to decreased MMP-1 secretion in rheumatoid arthritis synovial fibroblasts. |
| 14986114 |
A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer |
| 15638833 |
Functional polymorphisms of MMP1 acting in cis is associated with allelic expression imbalance in nornal lung |
| 15728253 |
MMP-1 expression is maintained at a low level by Cdc42 via a repression of the Rac1 and ERK1/2 pathways when cell/extracellular-matrix interactions via integrins induce cytoskeleton organization |
| 11831026 |
role in degradation of extracellular matrix and joint destruction |
| 12060661 |
Activation of p38 alpha MAPK enhances its expression by mRNA stabilization |
| 12960156 |
monocyte matrix metalloproteinase-1 and -9 are differentially regulated by interferon gamma through tumor necrosis factor-alpha and caspase 8 |
| 15312099 |
polymorphisms do not influence susceptibility to periodontitis in Japanese patients |
| 15818737 |
in hepatocellular carcinoma cells, fibril- and fixed-collagen have opposite effects on MMP-1 production without affecting TIMP production |
| 16168111 |
Monocyte and macrophage cells in the breast tumor microenvironment play an important role in the modulation of MMP-1. |
| 16267613 |
Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 is associated with breast cancer |
| 16774538 |
This study suggests that a single nucleotide polymorphism in the MMP-1 promoter region of -1607bp may be associated with severe chronic periodontitis in a Chinese population. |
| 17035633 |
Screening for Wnt5a-regulated genes in cultured endothelial cells identified several encoding angiogenic regulators, including matrix metalloproteinase-1, an interstitial collagenase, and Tie-2, a receptor for angiopoietins. |
| 17303772 |
simvastatin, by inhibiting Rac1 activity, reduces MMP1 expression and collagen degradation in human smooth muscle cells. |
| 17429393 |
epiregulin, COX2, and MMP1 and 2 collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis |
| 17488873 |
MMP1 mRNA remains associated with polysomes during hypoxia. |
| 14692651 |
High levels of MMP-1 expression, which may contribute to the invasive potential of these breast cancer cells |
| 14707126 |
induction by calveolin 1 |
| 14707454 |
Low levels of MT1-MMP, MMP-1 and AI were found to be favourable markers significantly associated with longer survival in advanced colorectal carcinoma. |
| 12622858 |
a polymorphism in the promoter region is associated with the severe chronic periodontitis phenotype in non-smokers |
| 12676763 |
MMP-1 induces progressive adult-onset emphysema by the selective degradation of type III collagen within the alveolar wall. |
| 15184373 |
collagenase-1 (MMP-1) levels increase during melanoma progression through mitogen-activated protein kinase (MAPK) pathway |
| 12054564 |
lack of expression in Ewing sarcoma may be due to loss of accessibility of regulatory element to the specific fusion protein in vivo |
| 15182858 |
peroxidation and the production of peroxides are important events in the signalling pathway of MMP-1 activation by ultraviolet A rays |
| 15375490 |
Overexpression of MMP-1 is associated with non-small cell lung cancer |
| 11762702 |
17beta-estradiol represses MMP-1 synthesis, and this effect may contribute to its action on the inhibition of bone resorption |
| 12528113 |
A novel promoter element was detected in the human MMP1 gene, and the inflammation-responsive transcription factor SAF-1 was found to interact with it in osteoarthritis |
| 14512169 |
Postmortem brain tissue analysis demonstrates accumulation of MMP-1 in macrophages/microglial cells in Durck's granulomas of patients with cerebral malaria. |
| 15754326 |
Over expression of MMP-1 is associated with lymphatic metastasis of nonsmall cell lung carcinoma |
| 15879464 |
MMP1 promoter SNP haplotype may modify susceptibility to endometriosis. |
| 16103692 |
The capability of ANG II to induce functionally active MMP in human smooth muscle cells may contribute to the altered plaque composition seen in complicated stages of atherosclerosis |
| 16321971 |
in gastric epithelial cells, H. pylori up-regulates MMP-1 in a type IV secretion system-dependent manner via JNK and ERK1/2 |
| 16623785 |
There was a clear increase in the number of MMP-1-reactive capillaries and fibroblasts in congenital diaphragmatic hernia lungs compared with controls. |
| 17151781 |
nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1, 2, 3, and 13, thereby tipping the balance between bone matrix formation and resorption toward the latter process |
| 11705862 |
Patients with detectable concentrations of urinary MMP-1 had higher rates of disease progression and death from bladder cancer than patients with undetectable urinary MMP-1. |
| 11836255 |
induction in fibroblasts by basic calcium phosphate crystals |
| 12432557 |
Genotyping was carried out using PCR-RFLP and direct sequencing. In the MMP-1 gene polymorphism, the frequency of the 2G/2G genotype that is associated with higher enzyme activity was significantly increased in colorectal cancer patients |
| 11875051 |
These data suggest that polymorphisms in the MMP1 and MMP12 genes, but not MMP9, are either causative factors in smoking-related lung injury or are in linkage disequilibrium with causative polymorphisms |
| 14550952 |
We found a correlation between promoter polymorphism and MMP-1 expression, and that this SNP was correlated with the clinical stage of cervical cancer. |
| 13129650 |
Cultured vascular smooth muscle cells infected with Chlamydia pneumoniae secreted increased quantities of MMP-1 protein. |
| 15149160 |
a matrix metalloproteinase 1 promoter gene polymorphism may be associated with lymphnode metastasis in patients with breast cancer |
| 12949792 |
Upregulation of mmp-1 ia assiciated with neoplasm invasiveness in Hereditary nonpolyposis colorectal cancers |
| 15350133 |
MMP-1 is found to be less efficient at processing triple-helical peptidase substrates than is MMP-14, which may explain the relative collagen specificity of MMP-1. |
| 12177784 |
keratinocyte-fibroblast interactions are mediated by multiple stimulating agents acting on specific receptors to induce signalling through different mitogen-activated protein kinase pathways leading to altered expression of key biological functions. |
| 15499569 |
The specific reduction of invasive behavior by human chondrosarcoma cells transfected with matrix metalloproteinase-1 (MMP-1) siRNA supports the hypothesis that MMP-1 is involved in initiation of chondrosarcoma metastasis. |
| 12767235 |
MT1-MMP-catalyzed release of beta-amyloid precursor protein leads to reduction of the extracellular matrix-associated gelatinase A inhibitor, sAPP, thus making it feasible for gelatinase A to exert proteolytic activity only near its activator, MT1-MMP |
| 14558091 |
catabolic role of ET-1 in osteoarthritis cartilage via MMP-1 and MMP-13 up-regulation. |
| 14729059 |
Mutant MMP1 lacking the cytoplasmic tail is recruited to membrane microdomains in breast carcinoma cells. |
| 15832405 |
The 2G or 1G SNP in the MMP1 promoter might not modify the risk of esophageal squamous carcinoma and gastric cardiac adenocarcinoma development |
| 16098031 |
stratifin stimulates fibroblast MMP-1 levels through the activation of c-fos and MAPK pathway |
| 16213873 |
Although MMP-1 is not detected in patients with persistent ovarian cysts, MMP-2 and MMP-9 are expressed in all of the cysts |
| 16288711 |
results suggest that gingival fibroblast are stimulated by monocytes resulting in enhanced expression of MMP-1 and TIMP-1 and that the enhanced MMP-1 expression, in contrast to TIMP-1, is partly mediated by ICAM-1 and the signal pathway p38 MAPK |
| 16890240 |
Results describe the crystal structure of the active form of human matrix metalloproteinase-1 at 2.67 A resolution. |
| 16945025 |
No association between polymorphism and gingival enlargement was revealed in kidney transplant patients who were administered cyclosporin A as a principal immunosuppressive agent |
| 16972994 |
MMPs play a key role in regulating the balance of structural proteins of the articular cartilage matrix according to local mechanical demands |
| 17339606 |
These results suggest that the polymorphisms exert haplotype effects on the transcriptional regulation of the MMP1 gene in cancer cells. |
| 17564313 |
Expression of MMP1 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissue. |
| 14515149 |
Matrix metalloproteinase 1 (interstitial collagenase)is upregulated in endothelial cells by prostaglandin-J2. |
| 14764579 |
MMP-1 is ERK dependent and is upregulated after cigarette smoke exposure |
| 12667140 |
catalytic activity on the cell surface is regulated through a vacuolar H(+)-ATPase-dependent degradation process |
| 12861139 |
study showed no change in metalloproteinase-1 production in response to varying estrogen levels in fibroblasts that were derived from incontinent women |
| 14705229 |
stimulated expression of MMP-1 and MMP-9 may contribute to the invasive activity and the bone and cartilage loss in pigmented villonodular synovitis |
| 15688379 |
Single nucleotide polymorphism in Ets binding site of the matrix metalloproteinase-1 promoter is associated with nasopharyngeal carcinoma |
| 15817699 |
Cytokine-stimulated monocytes release Angiotensin II, which is an integral component of the signal transduction pathway that leads to MMP-1 production. |
| 16807369 |
decrease in Tat-induced neurotoxicity and HIV transactivation is due to Tat's enzymatic cleavage by MMP-1 |
| 16972255 |
Data show that UVB irradiation increases PTEN/Akt phosphorylation in dermal fibroblasts, and inhibition of PTEN and activation of Akt by phosphorylation are involved in UVB-induced MMP-1 and -3 secretions through upregulation of AP-1 activity. |
| 17245132 |
Emphasis of this review is on membrane type-1 matrix metalloproteinase (MT1-MMP)-induced chromosome instability which leads to the transition from normalcy to malignancy. |
| 17335808 |
We conclude that induction of MMP1 participates in cell invasion and also plays an important role in HIF-1alpha-induced activation of MMP2. |
| 17558677 |
MMP-1 is up-regulated by substance P to promote collagen degradation in lung fibroblasts. |
| 15611040 |
The catalytic metalloproteinase domain and the C-terminal hemopexin domain show the classical MMP-fold, but the structure has revealed new features in surface properties |
