BioPortfolio - MMP3 publications

Melittin may exert its anti-rheumatoid effects, at least in part, by inhibiting MMP3 production, most likely through inhibition of NF-kappaB activity.

17559909

describes the site-specific distribution and activities of MMPs and therefore might help in elucidating the molecular mechanisms in pathologies such as premature rupture of membranes

18063811

FOXO3a (forkhead box O3) increased the expression of MMP-3 (stromelysin-1)in human umbilical vein endothelial cells

18028894

MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to idiopathic dilated cardiomyopathy.

18225577

The high expression 5A allele of the MMP-3 gene is associated with an increased risk for oral cancer in certain individuals.

18220784

Performed molecular docking simulations to study binding at the S1' pocket in the apo form of MMP3.

17765638

Finds the MMP-3 promoter haplotype -1612 5A/6A is a novel marker of an adverse disease course progession in patients with mitral valve prolpase.

17929133

matrix metalloproteinase-3 has a role in inflammation and progression of rheumatoid arthritis

17958893

This study does not provide strong evidence for further investigation into the role of the MMP2 and MMP3 variants in melanoma progression

17436000

Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells

18077489

MMP-3 functional polymorphism is associated with serum MMP-3 titre, but is not a direct predictor for outcome measures in Japanese rheumatoid arthritis patients.

17710450

The adducts of the catalytic domain of matrix metalloproteinase-3 (MMP3) with three different nonpeptidic inhibitors were structurally characterized.

18007247

MMP-3 and IL-6 promoter polymorphisms constitute important factors for the genetic predisposition to scoliosis

17911432

associate the 5A/6A polymorphism of the MMP-3 gene with radiographic progression of rheumatoid arthritis

17316652

enhanced cell cycle entry, increased MAPK signaling, and downregulated MMP-1 and MMP-3 seen in diabetic arterial vasculature could have a role in progressive atherosclerosis and postangioplasty restenosis in diabetic patients

17763214

Serum levels may be a potential marker of disease activity in spondyloarthropathy.

17502998

MMP-3 polymorphisms may not be independent factors to influence susceptibility to adult astrocytoma

17617837

MMP-3 transcript and protein levels were significantly higher in oral squamous cell carcinoma masses than in neighboring tissues. MMP-3 function may be required in most OSCCs; may support the anchorage-independent growth of OSCC and esophageal carcinoma.

17033924

No convincing evidence was found to support the association of MMP3 SNPs with increased breast cancer risk or survival.

15203551

Data suggest that proMMP-3 (prostromelysin 1) may play an essential role in degrading and remodeling the extracellular matrix in workers with pneumoconiosis, and that proMMP-3 may also reflect the stage of pneumoconiosis disease.

15863497

extracellularly secreted alpha-synuclein is processed via the activation of MMP-3

15823277

the particular combination of MMP3 and MMP9 genotypes present at susceptibility loci may contribute to heterogeneity in the presentation of atherosclerosis.

15274394

The presence of the MMP1-2G and MMP3-6A alleles seemed to be associated with decreased risk of head and neck squamous cell carcinoma but mainly when they were carried by the same haplotype.

12866026

Increased matrix metalloproteinase-3 expression accounts for invasive properties of human astrocytoma cell lines

16802342

CDK-4/6 modulated the production of MMP-3 and MCP-1.

11824472

Modulation of angiogenesis and progelatinase a by thrombin receptor agonists and antagonists.

15288468

No general associations of MMP-1 and MMP-3 genes to primary sclerosing cholangitis(PSC) or ulcerative colitis(UC) among Norwegians, but specific alleles were associated to subsets of PSC patients with UC and cholangiocarcinoma.

15389640

Results point to a functional link between matrix metalloproteinase-3 and E-cadherin.

15955221

MMP-3 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases.

12034345

destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells.

14998290

The results suggest that the 5A/6A polymorphism of MMP-3 gene may not be linked with appearance and/or progression of ovarian cancer.

12837283

MMP3 is a senescence-associated gene in normal human oral keratinocytes.

16822591

We found that subjects APOE epsilon4 non-carriers and 6A/6A homozygous for the MMP-3 polymorphism were at increased risk of dementia.

17434489

Accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha.

12761889

regulation of expression by ATP

17589947

Allelic composition at the examined SNPs in genes coding for TIMP-1 and MMP-3 affect Crohn's disease susceptibility and/or phenotype, i.e., fistulizing disease, stricture pathogenesis and first disease localisation.

12473595

A single nucleotide polymorphism in MMP-3 promoter is associated with invasive behaviour in breast cancer

16919028

Loss of MMP-2, MMP-3 and FN in lichen planus may be associated with the destruction of the epidermal basal layer and these MMPs may be involved in the pathogenesis of interface dermatitis.

17125518

A MMP3 polymorphism is associated with increased risk of colorectal neoplasms and small adenomas.

15383690

Intra-articular hyaluronic acid may rescue inflamed joints from bone and cartilage destruction by reducing the production of MMP-3.

15763339

Hepatitis B X protein exerts selective transcriptional control in hepatoma cells and induces cellular migration through the activation of MMP-3.

12204805

The severe coronary atherosclerotic lesions were significantly associated with the MMP3 genotype as an independent factor of the coronary lesions.

15788677

Concomitant high expression of stromelysin 3 and Ets-1 favors the development of a precancerous state in oral cancers

16088212

collagen III, and probably fibronectin, are degraded extracellularly in smooth muscle cells from varicose veins by a mechanism involving MMPs, and maybe MMP3 by a direct or an indirect pathway

12009331

involvement of MAPKs, AP-1 and NF-kappa B transcription factors in the IL-1 induction of MMP-3 and MMP-13 in chondrocytes

15290728

CD154 induced production of TNF-alpha, IL-6, and MMP-3 in rheumatoid arthritis chondrocytes.

12832381

The increase in antigenic levels of uPA and MMP-3 in endometrium of women with endometriosis might contribute to the invasive potential of endometrial cells

15337261

In conclusion, our finding suggests that the MMP3 gene, especially together with APOE 4, may contribute to the development of AD.

15474069

Progesterone inhibition of MMP-3 expression and its support of endometrial integrity were prevented by local expression of MMP-3 in response to embryonic signaling.

15701845

Polymorphism in the promoter region of the MMP-3 is associated with colorectal cancer

15667946

Extracellular catalase induces STR1 in primary chondrocytes.

16871440

myelin basic protein charge isomer, component-8, was more susceptible to stromelysin-1 cleavage than myelin basic protein component-1; increased susceptibility of component-8 to proteolytic digestion may play a role in pathogenesis of multiple sclerosis

16935611

The two genes (MMP3 and TIMP1) may not play a crucial role for high myopia in young Taiwanese men.

17198194

Pancreatic myofibroblasts may play an important role in extracellular matrix turnover via MMP-3 secretion in the pancreas

15319295

Polymorphisms in MMP-3 is associated with renal cell carcinoma

15319302

Single Nucleotide Polymorphism in matrix metalloproteinase-3 promoter is associated with lymphatic metastasis in esophageal squamous cell carcinoma

15342709

association of Crohn's disease susceptibility with the stromelysin-1 gene 5A/6A polymorphism in a cohort of German sporadic Crohn's disease trios

15610507

heat shock-induced expression of MMP-1 and MMP-3 is mediated via an IL-6-dependent autocrine mechanism.

15665388

in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with ischaemic heart disease

16516860

Finally, we found that induction of mmp-3 and mmp-10 gene expression by hypomethylation was cell-specific, suggesting that epigenetic changes may predispose cells to express stromelysin genes.

16904077

The common 5A/6A promoter polymorphism of MMP3 appears to be functional only during specific environmental conditions involving inflammation.

16311244

matrix metalloproteinase 1, 3 and 12 haplotypes may associated with development of lung cancer, particularly among never smokers and men

12651627

expression and regulation by intestinal myofibroblasts in inflammatory bowel disease

12784383

The proliferative response to a MMP-3 epitope was similar in rheumatoid arthritis patients and controls; the MMP-3 epitope increased IL-4, and IL-1beta and tumor necrosis factor-a production of arthritis lymphocytes, but not cytokines in controls.

15716694

The stromelysin-1 5A-1171-6A genotype is an important determinant of blood pressure in this general population sample.

16102106

The stromelysin-1 5A gene polymorphism was an independent survival predictor after index premature myocardial infarction.

15640153

MMP-1 and MMP-3 secretion by gastric epithelial cells are differentially regulated by E prostaglandins and MAPKs

12071839

Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts.

12034715

cooperative binding of promoter with ETS-1 transcription factor

15009479

Polymorphism is not associated with myocardial infarct in Japan.

11977998

The 6A6A MMP3 genotype is a genetic susceptibility factor for restenosis after angioplasty without stenting.

15312099

polymorphisms do not influence susceptibility to periodontitis in Japanese patients

16158251

The expression of MMP3 is consistently significantly higher in neoplastic brain tissue compared to normal brain tissue, and may be involved in the process of metastasis of breast cancer to the brain.

11841844

can cleave all subclasses of igG at a specific conserved site

17024375

MMP3 sequence variation was significantly associated with variation in leukoaraiosis volume in Whites.

12867428

proteolysis of SPARC by MMP-3 produced peptides that regulate endothelial cell proliferation and influence angiogenesis

15033492

MMP3, MMP9, and TGFbeta1 are important for the modulation, composition, and maintenance of the ECM in oral squamous cell carcinoma

12485468

The presence of this protein has a higher risk for arteriosclerosis in men who are smokers.

15529384

Ox-LDL, mediated by LOX-1, enhanced MMP-3 production in articular chondrocytes. Increased ox-LDL with elevated of LOX-1 in rheumatoid arthritis(RA) cartilage indicates specific role of receptor-ligand interaction in cartilage pathology in RA.

12230559

data provide evidence that MMP-3 can inhibit breast tumour cell invasion in vitro by a mechanism involving plasminogen degradation to fragments that limit plasminogen activation and the degradation of laminin

12952836

The present results indicate that MMP-2 can be helpful in diagnosing Takayasu arteritis [TA] and that MMP-3 and MMP-9 can be used as activity markers for TA

15879464

MMP3 promoter SNP is unlikely to be associated with endometriosis in the population of North China.

16972019

sFas, sFas-L, and MMP-3, which were significantly elevated in sera of active untreated AOSD patients and paralleled disease activity, may be involved in the pathogenesis of this disease

16984617

TUNEL-positive cells and MMP-3- and -13-expressing cells were distributed in the degenerative articular cartilage and reparative fibrocartilage tissue in osteochondritis dissecans (OCD) of the elbow.

17003494

Nuclear MMP-3 can induce apoptosis via its catalytic activity.

17151781

nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1, 2, 3, and 13, thereby tipping the balance between bone matrix formation and resorption toward the latter process

17319946

IL-4 suppression of IL-1-induced MMP-3 expression in HGF is independent of lipoxygenase activity and activation of PPARgamma.

17530713

MMP-3 is a significant independent predictor of radiographic progression in patients with ankylosing spondylitis, particularly in those with preexisting radiographic damage.

11836255

induction in fibroblasts by basic calcium phosphate crystals

12432557

With regard to the MMP-3 polymorphism, unexpectedly, the frequency of the 6A/6A genotype causing lower enzyme activity was significantly increased in patients (p = 0.0129; OR = 2.110; 95% CI = 1.165-3.822).

11982752

Stromelysin-1 activation correlates with invasiveness in squamous cell carcinoma

12727228

Data demonstrate that blockade of the ERK pathway suppressed the expression of matrix metalloproteinases 3, 9, and 14, and CD44, and markedly inhibited the invasiveness of tumor cells.

13129650

Cultured vascular smooth muscle cells infected with Chlamydia pneumoniae secreted increased quantities of MMP-3 protein

15102660

MMP3 may have a role in response to chemotherapy in head and neck squamous cell carcinoma, as demonstrated by an analysis of its polymorphism

15467919

the MMP3 -1612 5A/6A polymorphism is associated with myocardial infarction in a Chinese Han population

16100452

Findings suggest that MMP-3 6A/6A genotype may be an independent risk factor for coronary artery lesions formation in Kawasaki disease.

12736398

stromelysin-1, which has the ability to degrade the mucosal extra-cellular matrix, may be responsible for the extensive tissue injury in infants with necrotizing enterocolitis

15161710

MMP3 5A/6A promoter polymorphism does not appear to influence breast cancer susceptibility but may be linked to a higher risk for metastasizing among breast cancer patients

16677108

matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia

16972994

MMPs play a key role in regulating the balance of structural proteins of the articular cartilage matrix according to local mechanical demands

17065356

MMP3 pathway is altered in human obesity, but this alteration may be the result of a combination of genetic variation within the MMP3 locus itself.

17381556

Taken together, our data suggest that numerous genes may influence ACE activity.

17564313

Expression of MMP3 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissue.

12634064

N-TIMP-1 interaction with the catalytic domain of MMP-3 investigation by titration calorimetry and 15N NMR

12750310

Matrix metalloproteinase-3 polymorphism contributes to age-related aortic stiffening through modulation of gene and protein expression.

15234427

Recent large Japanese case-control studies identified connexin-37 (GJA-4), plasminogen activator inhibitor-1 (PAI-1), and stromelysin-1 (MMP-3) polymorphisms as risk factors for myocardial infarction.

16615041

protein expression levels of MMP-3 were higher in colorectal tumor tissues than in the corresponding normal tissues.

17000887

Smokers homo/heterozygous for stromelysin-1 5A/6A show an increased rish of Buerger disease.

16972255

Data show that UVB irradiation increases PTEN/Akt phosphorylation in dermal fibroblasts, and inhibition of PTEN and activation of Akt by phosphorylation are involved in UVB-induced MMP-1 and -3 secretions through upregulation of AP-1 activity.

17320799

MMP and TIMP plasma levels in premature coronary artery disease are linked to clinical presentation and markers of inflammation and metabolic disorders rather than to genetic polymorphisms.

15070833

cleaves IGFBP-1 at (145)Lys/Lys(146), resulting in a small (9-kDa) C-terminal peptide of IGFBP-1 in first trimester decidua

15094779

MMP-3 is specifically expressed in squamous cell carcinomas of the head and neck and its expression correlates with their invasion capacity.

14715248

The observations are consistent with a downstream mediation role of MMP-3 in phosphoglucose isomerase/AMF-stimulated tumor cell metastasis.

12054564

lack of expresion in Ewing sarcoma may be due to loss of accessibility of regulatory element to the specific fusion protein in vivo

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