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dco


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Gene DB Home
Symbol:dco
Name(s):discs overgrown
Type:protein-coding
Organism:Drosophila melanogaster
Synonyms:0538/13, 0915/10, 1396/02, 1447/01, 1460/09, CG2048, CK1epsilon, CKIepsilon, DBT, DBT/CK1epsilon, DCO/CKIe, Dco/CK1, Discs overgrown/Double time, dCKIepsilon, dco-1, ddbt, l(3)S053813, l(3)S144701, l(3)dco, l(3)dco-1, l(3)discs overgrown, l(3)discs overgrown-1, l(3)j3B9, l(3)rK215
Links: Pubmed, Entrez Gene, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18258753 human casein kinase 1 epsilon cannot replace the activity of dbt in flies despite the high degree of similarity in primary sequence and kinase function
17893330 This first analysis of adult flies with a virtual lack of DBT activity demonstrates that DBT's kinase activity is necessary for normal circadian rhythms and that a general reduction of DBT kinase activity does not produce short periods.
14701759 expression of DBT in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
17134692 Dco coordinates tissue size by stimulating cell division/growth and blocking apoptosis via activation of DIAP1 expression.
14759367 doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
12442174 Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BIND-cubitus interruptus CG2125-PA [Drosophila melanogaster].Ci is phosphorylated by DCO after primed phosphorylation by PKAc. This interaction was modelled on a demonstrated interaction between Drosophila Ci and rat CK1-delta.-Pubmed

dco results (if any) from reagent suppliers

 Google CSE Logo
426229 Formic acid-d2 95 wt. % in D2O, 98 atom % D
Linear Formula: DCO2D. Molecular Weight: 48.04. EC Number: 213-057-3. MDL number : MFCD00037363. PubChem Substance ID: 24866689 ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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