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ASPA
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18264947 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 14699612 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 16437572 |
Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene |
| 12638939 |
the ASPA gene was analysed in 22 unrelated non-Jewish patients with Canavan disease, and 24 different mutations were found |
| 16669630 |
molecular weight of the purified enzyme is higher than predicted, suggesting the presence of post-translational modifications. Deglycosylation of aspartoacylase or mutation at glycosylation site causes decreased enzyme stability and catalytic activity |
| 17194761 |
the N-terminal domain of aspartoacylase adopts a protein fold similar to that of zinc-dependent hydrolases related to carboxypeptidases A |
| 17391648 |
These results show that aspartoacylase is a member of the caboxypeptidase A family and offer novel explanations for most loss-of-function aspartoacylase mutations associated with Canavan Disease. |
| 16935940 |
a green fluorescent protein-human ASPA fusion protein larger than the permissible size for the nuclear pore complex was enzymatically active and showed mixed nuclear-cytoplasmic distribution. |
| 17027983 |
The finding that wild-type and Glu178Asp have the same K(m) but different k(cat) values confirms the idea that the carboxylate group contributes importantly to the enzymatic activity of aspartoacylase. |
Recent Publications on ASPA: |  |
Proteolytic activity, mycotoxins and andrastin A in Penicillium roqueforti strains isolated from Cabrales, Valdeon and Bejes-Tresviso local varieties of blue-veined cheeses.
High quality local varieties of blue-veined cheese are made in the... | 20th October, 2009
| Institute of Biotechnology of Leon (INBIOTEC), Leon, Spain.
| Int J Food Microbiol. 2009 Nov 30;136(1):18-25. Epub 2009 Sep 23.
DOI Direct Link |
Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease?
Canavan disease (CD) is a genetic degenerative brain disorder associated... | 20th October, 2009
| Center for Neurochemistry, Nathan S Kline Institute for Psychiatric
| Neurochem Res. 2009 Sep;34(9):1523-34. Epub 2009 Mar 25.
DOI Direct Link |
First multi-locus sequence typing scheme for Arcobacter spp.
BACKGROUND: Arcobacter spp. are a common contaminant of food and water,... | 16th September, 2009
| Produce Safety and Microbiology Research Unit, Agricultural Research
| BMC Microbiol. 2009 Sep 14;9:196.
DOI Direct Link |
Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease.
Loss of the oligodendrocyte (OL)-specific enzyme aspartoacylase (ASPA)... | 10th September, 2009
| Intellectual and Developmental Disabilities Research Center, Semel
| J Neurosci Res. 2009 Nov 15;87(15):3415-27.
DOI Direct Link |
A prediction rule for estimating the risk of bacteremia in patients with community-acquired pneumonia.
BACKGROUND: We endeavored to construct a simple score based entirely on... | 1st September, 2009
| Services of 1Internal Medicine, Hospital Universitari Arnau de Vilanova,
| Clin Infect Dis. 2009 Aug 1;49(3):409-16.
DOI Direct Link |
→View more research publications. |
ASPA results (if any) from reagent suppliers | 
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ASPA antibody (ab54849) | Abcam
Aspartoacylase (ASPA) is an enzyme that catalyzes the conversion of N-acetyl_L- aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the br...
http://www.abcam.com/ASPA-antibody-ab54849.html...
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Aspartoacylase (H-93) Antibody sc-98734
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ASPA, 443, 17p13.3, P45381 ...
http://www.scbt.com/datasheet-98734-aspartoacylase-h-93-anti...
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ASPA antibodies: Neuroscience > Neurology process ...
ASPA antibodies. ... ASPA antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab54849 · ASPA antibody ...
http://www.abcam.com/index.html?t=226097&pt=1&c=3355&ei=&mu=...
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3C-3E
Monoclonal Anti-ASPA antibody produced in mouse clone 3C11, purified immunoglobulin, buffered aqueous solution, 3C11 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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Abgent - Neurosciences Antibodies
AP2019a, ASCL1 (Achaete-scute homolog 1) Antibody (N-term), WB, IHC, E, H, M. AT1218aNEW, ASPA monoclonal antibody (M09), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/neurosciences...
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MBL Oligomer ELISA Kit (KIT 029)
Aspa J, Briones ML, Garcia-Saavedra A, Rajas O, Blanquer J,. Caballero-Hidalgo A , Marcos-Ramos JA, Hernandez-Lopez. J, Rodriguez-Gallego C (2008) ...
http://www.antibodyshop.com/content/download/842/10533/versi...
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Abgent - Cell and Function Antibodies
AT1217aNEW, ASNS monoclonal antibody (M01), ELISA,S-ELISA, H. AT1218aNEW, ASPA monoclonal antibody (M09), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...
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