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MTHFR

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Symbol:	MTHFR
Name(s):	5,10-methylenetetrahydrofolate reductase (NADPH)
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	-
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
17976958	T allele subjects, the risk was almost four times greater, despite similar antipsychotic exposure. Both waist circumference and MTHFR genotype significantly predicted insulin resistance
18257130	MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome
17900242	The MTHFR C677T polymorphism may play a role in influencing liver fibrosis progression in patients with recurrent hepatitis C, in conjunction with donor age, but not via steatosis promotion.
18065414	ER stress increases MTHFR expression and IRE1 and c-Jun mediate this activation
18199718	A significant association was found between MTHFR C677T genetic polymorphism and CpG island methylation status of MGMT gene
18333414	Mutation of MTHFR C677T is associated with fetal loss in first trimester.
18199722	Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18200034	Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18203168	Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18204887	Observational study of gene-disease association. (HuGE Navigator)
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	5,10-methylenetetrahydrofolate reductase	U6 snRNA-associated Sm-like protein LSm8	-	-	Pubmed
HPRD	5,10-methylenetetrahydrofolate reductase	U6 snRNA-associated Sm-like protein LSm8	-	-	Pubmed

Recent Publications on MTHFR:
Genetic cardiovascular risk factors and age-related macular degeneration. Abstract. Purpose: To investigate the association between genetic...	29th October, 2009	Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery,	Acta Ophthalmol. 2009 Oct 23. DOI Direct Link
[Bone quality markers: pentosidine, homocysteine, and MTHFR polymorphism] Bone quality is thought to encompass the structural and material...	29th October, 2009	Department of Orthopedic Surgery, Jikei University School of Medicine,	Rinsho Byori. 2009 Sep;57(9):876-83.
Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial. PURPOSE: Predicting efficacy and toxicity could potentially allow...	28th October, 2009	Oncology & Clinical Research and Pathology & Tumour Biology Sections,	J Clin Oncol. 2009 Oct 26. DOI Direct Link
Recipient genetic determinants of inflammatory process and nonstandard atherosclerosis risk factors affect kidney graft function early posttransplantation. We analyzed the connections between recipient genetic features and...	28th October, 2009	Department of Nephrology and Transplantation Medicine, Wroclaw Medical	Transplant Proc. 2009 Oct;41(8):3060-2. DOI Direct Link
Impact of donor-dependent genetic factors on long-term renal graft function. Our aim was to study the association of donor genetic features with...	28th October, 2009	Department of Nephrology and Transplantation Medicine, Wroclaw Medical	Transplant Proc. 2009 Oct;41(8):2978-80. DOI Direct Link
→View more research publications.

Press Releases on MTHFR:
Reportlinker Adds Who's Doing What in Molecular Diagnostics? - Kalorama / Emmes Survey of US Laboratories Report	24th September, 2009	Reportlinker	-- Communicable Diseases - CMV (Cytomegalovirus), EBV (Epstein-Barr Virus), Group B Strep, Enterovirus What Labs Do Now, What They are Planning in the Future
TriLink BioTechnologies, Inc. Announces Supply Agreement With Osmetech Molecular Diagnostics	18th May, 2009	TriLink BioTechnologies, Inc.	SAN DIEGO, May 18 /PRNewswire/ -- TriLink BioTechnologies, Inc. today announced that it has signed a service agreement with Osmetech Molecular Diagnostics to supply reagents for
Nanosphere Inc. Awarded Two NIH Grants to Assess Genetic Risk Factors for	1st January, 1970	Nanosphere	Tm BIOSCIENCE LAUNCHES COAGULATION GENETIC TESTS	1st January, 1970	Tmbioscience

BioNews Results for MTHFR :
Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study	Nature Chemical Biology: Oct 7 2009 9:14AM Matching: mthfr
Reportlinker Adds Who's Doing What in Molecular Diagnostics? - Kalorama / Emmes Survey of US Laboratories Report	SmartBrief: Sep 24 2009 5:38PM Matching: mthfr
Genetics & Genomics - Findings in genetics & genomics reported from A. Haghighatgoo and co-researchers	NewsRX: Sep 20 2009 3:45PM Matching: mthfr
Gene study allays folate-prostate cancer fears	Nutra Ingredients USA: Sep 14 2009 1:51PM Matching: mthfr
Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syndrome and congenital heart defects	MDLinx: Sep 8 2009 9:37AM Matching: mthfr
Promote your company here: BioNewsCast - Press Release Distribution	→View more news.

Clinical Trials:
Examining B12 Deficiency Associated With C677T Mutation on MTHFR Gene in Terms of Commonness and Endothelial Function

Patents:
US Patent No.	Title
6964848	Invasion assay
7195871	Methods and compositions for detecting target sequences
7201929	Aspirin formulation for cardiovascular health
7202229	Aspirin formulation for cardiovascular health
7205105	Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis
→View more patents.

MTHFR results (if any) from reagent suppliers

MTHFR Antibody / MTHFR Antibodies MTHFR Antibody / MTHFR Antibodies. ... MTHFR specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ... http://www.scbt.com/table-mthfr.html...
MTHFR monoclonal antibody (M06) MTHFR (AAH18766, 1 a.a. ~ 74 a.a) full length recombinant protein with GST tag. ... Detection limit for recombinant GST tagged MTHFR is approximately ... http://www.abgent.com/products/catalog_no/AT2930a_MTHFR_mono...
MTHFR (N-20) Antibody sc-17079 MTHFR shRNA (h) Lentiviral Particles, sc-43950-V, 200 µl ... See how others have used MTHFR (N-20): sc-17079 antibody and or MTHFR (N-20) antibody ... http://www.scbt.com/datasheet-17079-mthfr-n-20-antibody.html...
MTHFR antibodies: Signal Transduction > Metabolism > Amino Acids ... MTHFR antibodies. ... MTHFR antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab55530 · MTHFR antibody ... http://www.abcam.com/index.html?t=227357&pt=1&c=712&ei=&mu=r...
MTHFR Antibody / MTHFR Antibodies MTHFR Antibody / MTHFR Antibodies. ... MTHFR specific siRNA, sHRNA Plasmid과 shRNA Lentiviral Particles gene silencers 도 제공합니다. ... http://www.scbt.com/ko/table-mthfr.html...
Protein Modification - Methylation Antibody AT2929aNEW, MTHFR monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AT2930aNEW, MTHFR monoclonal antibody (M06), ELISA,S-ELISA,WB-Re, H ... http://www.abgent.com/products/category/protein_modification...
MTHFR siRNA (h) sc-43950 Click here for details. suitable control antibody: MTHFR (N-20): sc-17079; sqRT- PCR Primer also available: MTHFR (h)-PR: sc-43950-PR, 20 µl ... http://www.scbt.com/ko/datasheet-43950-mthfr-sirna-h.html...

Search Bioportfolio and other Life Science Sites for MTHFR, or search for MTHFR on BioPortfolio's antibody search engine.
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MTHFR

Gene Information from Publications

Interacting gene products

Recent Publications on MTHFR:

Press Releases on MTHFR:

BioNews Results for MTHFR

Clinical Trials:

Patents:

MTHFR results (if any) from reagent suppliers