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MTHFR


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Symbol:MTHFR
Name(s):5,10-methylenetetrahydrofolate reductase (NADPH)
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17976958 T allele subjects, the risk was almost four times greater, despite similar antipsychotic exposure. Both waist circumference and MTHFR genotype significantly predicted insulin resistance
18257130 MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome
17900242 The MTHFR C677T polymorphism may play a role in influencing liver fibrosis progression in patients with recurrent hepatitis C, in conjunction with donor age, but not via steatosis promotion.
18065414 ER stress increases MTHFR expression and IRE1 and c-Jun mediate this activation
18199718 A significant association was found between MTHFR C677T genetic polymorphism and CpG island methylation status of MGMT gene
18333414 Mutation of MTHFR C677T is associated with fetal loss in first trimester.
18199722 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18200034 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18203168 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18204887 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRD5,10-methylenetetrahydrofolate reductaseU6 snRNA-associated Sm-like protein LSm8--Pubmed
HPRD5,10-methylenetetrahydrofolate reductaseU6 snRNA-associated Sm-like protein LSm8--Pubmed

Recent Publications on MTHFR:

Pubmed Logo
Genetic cardiovascular risk factors and age-related macular degeneration.
Abstract. Purpose: To investigate the association between genetic...
29th October, 2009
Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery, Acta Ophthalmol. 2009 Oct 23.
DOI Direct Link
[Bone quality markers: pentosidine, homocysteine, and MTHFR polymorphism]
Bone quality is thought to encompass the structural and material...
29th October, 2009
Department of Orthopedic Surgery, Jikei University School of Medicine, Rinsho Byori. 2009 Sep;57(9):876-83.
Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial.
PURPOSE: Predicting efficacy and toxicity could potentially allow...
28th October, 2009
Oncology & Clinical Research and Pathology & Tumour Biology Sections, J Clin Oncol. 2009 Oct 26.
DOI Direct Link
Recipient genetic determinants of inflammatory process and nonstandard atherosclerosis risk factors affect kidney graft function early posttransplantation.
We analyzed the connections between recipient genetic features and...
28th October, 2009
Department of Nephrology and Transplantation Medicine, Wroclaw Medical Transplant Proc. 2009 Oct;41(8):3060-2.
DOI Direct Link
Impact of donor-dependent genetic factors on long-term renal graft function.
Our aim was to study the association of donor genetic features with...
28th October, 2009
Department of Nephrology and Transplantation Medicine, Wroclaw Medical Transplant Proc. 2009 Oct;41(8):2978-80.
DOI Direct Link

View more research publications.

Press Releases on MTHFR:

BioPortfolio Logo
Reportlinker Adds Who's Doing What in Molecular Diagnostics? - Kalorama / Emmes Survey of US Laboratories Report 24th September, 2009 Reportlinker
-- Communicable Diseases - CMV (Cytomegalovirus), EBV (Epstein-Barr Virus), Group B Strep, Enterovirus

What Labs Do Now, What They are Planning in the Future

TriLink BioTechnologies, Inc. Announces Supply Agreement With Osmetech Molecular Diagnostics 18th May, 2009 TriLink BioTechnologies, Inc.

SAN DIEGO, May 18 /PRNewswire/ -- TriLink BioTechnologies, Inc. today announced that it has signed a service agreement with Osmetech Molecular Diagnostics to supply reagents for

Nanosphere Inc. Awarded Two NIH Grants to Assess Genetic Risk Factors for 1st January, 1970 Nanosphere
 

Tm BIOSCIENCE LAUNCHES COAGULATION GENETIC TESTS

1st January, 1970 Tmbioscience
 

BioNews Results for MTHFR

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BioPortfolio Logo
Mutant gene cancer risk studied
Yorkshire Forward:  Oct 22 2009 2:54PM Matching: mthfr
Sheffield expert to study breast cancer risk in women
University of Sheffield:  Oct 21 2009 7:38PM Matching: mthfr
Breast Cancer Campaign: New Breast Cancer Research Funding for Sheffield
Genetic Engineering News:  Oct 21 2009 12:02PM Matching: mthfr
17,000 grant to university researcher for breast cancer research
News-Medical.Net:  Oct 21 2009 11:53AM Matching: mthfr
Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study
Nature Chemical Biology:  Oct 7 2009 9:14AM Matching: mthfr
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Examining B12 Deficiency Associated With C677T Mutation on MTHFR Gene in Terms of Commonness and Endothelial Function

Patents:

Patents logo
US Patent No.Title
7014865 Natural formulation for the treatment and prevention of depression, containing St. John's Wort and derivatives of dihydro- and tetrahydrofolic acid
7202229 Aspirin formulation for cardiovascular health
7205105 Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7256020 Methods and compositions for detecting target sequences

View more patents.

MTHFR results (if any) from reagent suppliers

Google CSE Logo
MTHFR Antibody / MTHFR Antibodies
MTHFR Antibody / MTHFR Antibodies. ... MTHFR specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-mthfr.html...

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MTHFR antibodies: Signal Transduction > Metabolism > Amino Acids ...
MTHFR antibodies. ... MTHFR antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab55530 · MTHFR antibody ...
http://www.abcam.com/index.html?t=227357&pt=1&c=712&ei=&mu=r...

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MTHFR (N-20) Antibody sc-17079
MTHFR shRNA (h) Lentiviral Particles, sc-43950-V, 200 µl ... See how others have used MTHFR (N-20): sc-17079 antibody and or MTHFR (N-20) antibody ...
http://www.scbt.com/datasheet-17079-mthfr-n-20-antibody.html...

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Protein Modification - Methylation Antibody
AT2929aNEW, MTHFR monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AT2930aNEW, MTHFR monoclonal antibody (M06), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

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MTHFR Antibody / MTHFR Antibodies
MTHFR Antibody / MTHFR Antibodies. ... MTHFR specific siRNA, sHRNA Plasmid과 shRNA Lentiviral Particles gene silencers 도 제공합니다. ...
http://www.scbt.com/ko/table-mthfr.html...

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00-218M Focus 23.1 BODY
The MTHFR gene was amplified with the primers. TGAAG GAGAA GGTGT CTGCG .... Analysis of the C677T nucleotide substitution in the MTHFR gene ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf/fo...

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MTHFR siRNA (h) sc-43950
Click here for details. suitable control antibody: MTHFR (N-20): sc-17079; sqRT- PCR Primer also available: MTHFR (h)-PR: sc-43950-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-43950-mthfr-sirna-h.html...

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