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MUC1
| Symbol: | MUC1 | | Name(s): | mucin 1, cell surface associated | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CD227, EMA, H23AG, MAM6, PEM, PEMT, PUM | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18161663 |
CA 15-3 levels might have a role in the response to EGFR inhibitors in patients with bronchioloalveolar carcinoma |
| 18268124 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17916995 |
A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human papillary thyroid carcinoma and papillary microcarcinoma |
| 18037881 |
MUC1 is important for physiological activation of IKKbeta and that overexpression of MUC1, as found in human cancers, confers sustained induction of the IKKbeta-NF-kappaB p65 pathway. |
| 11062147 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11464247 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12105832 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12734543 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15944787 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16357367 |
Observational study of gene-disease association and genetic testing. (HuGE Navigator) | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| BIND | Human bax gene, 5' region. | mucin 1, transmembrane | MUC1 C-ter interacts with the Bax promoter. | - | Pubmed |
| BIND | Human p21 gene, partial promoter sequence. | mucin 1, transmembrane | MUC1 C-ter interacts with the p21 promoter. | - | Pubmed |
| BIND | catenin, beta 1, 88kDa | mucin 1, transmembrane | MUC1 interacts with beta-catenin. | - | Pubmed |
| HPRD | catenin, beta 1, 88kDa | Mucin-1 precursor (Breast carcinoma... | - | - | Pubmed |
| HPRD | catenin, beta 1, 88kDa | Mucin-1 precursor (Breast carcinoma... | - | - | Pubmed |
| HPRD | catenin, delta 1 isoform 1B | Mucin-1 precursor (Breast carcinoma... | - | - | Pubmed |
| HPRD | epidermal growth factor receptor oncogene homolog, avian) | Mucin-1 precursor (Breast carcinoma... | - | - | Pubmed |
| HPRD | epidermal growth factor receptor oncogene homolog, avian) | Mucin-1 precursor (Breast carcinoma... | - | - | Pubmed |
| BIND | epidermal growth factor receptor isoform a | mucin 1, transmembrane | MUC1 interacts with and is tyrosine-phosphorylated by EGFR. | - | Pubmed |
| HPRD | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog | Mucin-1 precursor (Breast carcinoma... | - | - | Pubmed |
Recent Publications on MUC1: |  |
A Novel Bacillus Calmette-Guerin-based Breast Cancer Vaccine that Coexpresses Multiple Tandem Repeats of MUC1 and CD80 Breaks the Immune Tolerance and Inhibits MUC1-Positive Breast Cancer Growth.
Abstract Many approaches targeting MUC1 for breast tumor immunotherapy... | 3rd November, 2009
| 1 Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth
| Cancer Biother Radiopharm. 2009 Oct;24(5):607-13.
DOI Direct Link |
Tumor burden influences cytotoxic T cell development in metastatic breast cancer patients--a phase I/II study.
The influence of tumor burden on the generation of tumor antigen-specific... | 29th October, 2009
| Medical Service, Amarillo Veterans Affairs Health Care System, Amarillo,
| Immunol Invest. 2009;38(8):820-38.
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Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology.
Malignant ascites may be the first presentation of an unsuspected cancer.... | 27th October, 2009
| Department of Pathology, Wayne State University and Karmanos Cancer
| Diagn Cytopathol. 2009 Oct 23.
DOI Direct Link |
Functional Neoglycopeptides: Synthesis and Characterization of a New Class of MUC1 Glycoprotein Models Having Core 2-Based O-Glycan and Complex-Type N-Glycan Chains.
An efficient protocol for the construction of MUC1-related glycopeptide... | 27th October, 2009
| Division of Advanced Chemical Biology, Graduate School of Life Science,
| Biochemistry. 2009 Oct 30.
DOI Direct Link |
Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis.
Spontaneous immune responses in cancer patients have been described. Yet... | 22nd October, 2009
| Department of Obstetrics and Gynecology, University Hospital of
| Cancer Res. 2009 Nov 1;69(21):8420-8. Epub 2009 Oct 20.
DOI Direct Link |
→View more research publications. |
Press Releases on MUC1:
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| Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline |
30th September, 2009 |
Quest PharmaTech Inc. |
TSX Venture: QPT
EDMONTON, Sept. 30 /PRNewswire-FirstCall/ - Quest PharmaTech Inc. (TSX-V: QPT) ("Quest" or the "Company"), a pharmaceutical company developing
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| Oncothyreon announces initiation of Phase 3 trial of Stimuvax in breast cancer |
22nd June, 2009 |
Oncothyreon Inc. |
SEATTLE, June 22 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY) (TSX:ONY) (the "Company") today announced that Merck KGaA of Darmstadt, Germany, has initiated a global Phase 3
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| Merck KGaA acquires manufacturing rights for Stimuvax from Oncothyreon |
18th December, 2008 |
Oncothyreon Inc. |
SEATTLE, Dec. 18 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY) (TSX:ONY) announced today that Merck KGaA of Darmstadt, Germany has licensed the right to manufacture Stimuvax(R) and,
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| Oncothyreon announces prioritization plan for development programs |
2nd September, 2008 |
Oncothyreon Inc. |
SEATTLE, Sept. 2 /PRNewswire-FirstCall/ - Oncothyreon Inc. (NASDAQ: ONTY) (TSX: ONY) (the "Company") today announced a prioritization plan to focus the Company's resources on the
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| Stimuvax Phase 1/2 survival data support prior results |
2nd June, 2008 |
Oncothyreon Inc. |
BELLEVUE, WA, June 2 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq:
ONTY) (TSX: ONY) today announced the presentation of two-year survival data
from a Phase 1/2 multicenter study of
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MUC1 results (if any) from reagent suppliers | 
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The Abcam catalog
MUC1 antibodies. ... MUC1 antibody [LBS-1]. ICC/IF, IHC-Fr. Mouse monoclonal. Reacts with: Hu. ab20158 · MUC1 antibody [PR 4D1]. IHC-FoFr. Mouse monoclonal
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http://www.abcam.com/index.html?t=53037&pt=1&c=751...
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Anti-MUC1 Polyclonal Antibody
Polyclonal Antibody against MUC1 for use in Immunohistochemistry, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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MUC1 antibody [M9E7] (ab8322) | Abcam
Mouse monoclonal [M9E7] to MUC1. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some ...
http://www.abcam.com/MUC1-antibody-M9E7-ab8322.html...
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MUC1 antibody, Mucin-1 Antibody, Chicken IgY Polyclonal Antibody
Buy quality chicken MUC1 antibody (interacts with human mouse rat), anti-MUC1, Mucin-1 antibody, chicken igy polyclonal antibody, Mucin-1 Antibody, ...
http://www.genwaybio.com/product_info.php?products_id=600...
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Anti-MUC1 Monoclonal Antibody
Monoclonal Antibody against MUC1 for use in ELISA, Immunohistochemistry ( Paraffin, Frozen)
http://www.bioreagents.com/products/productDetails/productDe...
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MUC1 Antibody Anti-MUC1
MUC1 antibody can be used for Western blot at a suggested dilution at 0.5µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be ...
http://www.prosci-inc.com/shop/catalog1/MUC1-Antibody-p-1017...
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Anti-MUC1 Polyclonal Antibody
Polyclonal Antibody against MUC1 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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