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MUC1


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Symbol:MUC1
Name(s):mucin 1, cell surface associated
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD227, EMA, H23AG, MAM6, PEM, PEMT, PUM
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18161663 CA 15-3 levels might have a role in the response to EGFR inhibitors in patients with bronchioloalveolar carcinoma
18268124 Observational study of gene-disease association. (HuGE Navigator)
17916995 A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human papillary thyroid carcinoma and papillary microcarcinoma
18037881 MUC1 is important for physiological activation of IKKbeta and that overexpression of MUC1, as found in human cancers, confers sustained induction of the IKKbeta-NF-kappaB p65 pathway.
11062147 Observational study of gene-disease association. (HuGE Navigator)
11464247 Observational study of gene-disease association. (HuGE Navigator)
12105832 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
12734543 Observational study of gene-disease association. (HuGE Navigator)
15944787 Observational study of gene-disease association. (HuGE Navigator)
16357367 Observational study of gene-disease association and genetic testing. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHuman bax gene, 5' region.mucin 1, transmembraneMUC1 C-ter interacts with the Bax promoter.-Pubmed
BINDHuman p21 gene, partial promoter sequence.mucin 1, transmembraneMUC1 C-ter interacts with the p21 promoter.-Pubmed
BINDcatenin, beta 1, 88kDamucin 1, transmembraneMUC1 interacts with beta-catenin.-Pubmed
HPRDcatenin, beta 1, 88kDaMucin-1 precursor (Breast carcinoma...--Pubmed
HPRDcatenin, beta 1, 88kDaMucin-1 precursor (Breast carcinoma...--Pubmed
HPRDcatenin, delta 1 isoform 1BMucin-1 precursor (Breast carcinoma...--Pubmed
HPRDepidermal growth factor receptor oncogene homolog, avian)Mucin-1 precursor (Breast carcinoma...--Pubmed
HPRDepidermal growth factor receptor oncogene homolog, avian)Mucin-1 precursor (Breast carcinoma...--Pubmed
BINDepidermal growth factor receptor isoform amucin 1, transmembraneMUC1 interacts with and is tyrosine-phosphorylated by EGFR.-Pubmed
HPRDv-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologMucin-1 precursor (Breast carcinoma...--Pubmed

Recent Publications on MUC1:

Pubmed Logo
Surface Mucin-1 does not play a role in dendritic cell migration.
Mucin-1 (MUC1) is a transmembrane glycoprotein that is upregulated upon...
28th October, 2008
Department of Internal Medicine, Division of Haematology, University Mol Immunol. 2008 Oct 24.
DOI Direct Link
Positive KL-6 mucin expression combined with decreased membranous beta-catenin expression indicates worse prognosis in colorectal carcinoma.
Interaction of MUC1 with beta-catenin plays a significant role in tumor...
25th October, 2008
Minimally Invasive Surgery Center, Changzheng Hospital, Second Military Oncol Rep. 2008 Nov;20(5):1013-9.
Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy.
The delivery of stimulatory signals to dendritic cells (DCs) in the tumor...
25th October, 2008
1Molecular Immunology Department, Transgene, Strasbourg, France. Cancer Gene Ther. 2008 Oct 24.
DOI Direct Link
MUC1 expression in canine malignant mammary tumours and relationship to clinicopathological features.
Mucin-1 (MUC1) is over-expressed in human breast carcinomas and is linked...
25th October, 2008
Institute of Molecular Pathology and Immunology (IPATIMUP), Rua Dr. Vet J. 2008 Oct 21.
DOI Direct Link
MVA-MUC1-IL2 vaccine immunotherapy (TG4010) improves PSA doubling time in patients with prostate cancer with biochemical failure.
Purpose: TG4010 is a recombinant MVA vector expressing the...
22nd October, 2008
Department of Solid Tumor Oncology Taussig Cancer Center, Cleveland Invest New Drugs. 2008 Oct 18.
DOI Direct Link

View more research publications.

BioNews Results for MUC1

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Cancer: Scientists at University of Nebraska, Eppley Institute for Research in Cancer and Allied Diseases desc
NewsRX:  Nov 4 2008 9:30PM Matching: muc1
Scientists at University of Nebraska, Eppley Institute for Research in Cancer and Allied Diseases describe res
Calibre Macro World:  Oct 31 2008 12:03AM Matching: muc1
Anti-CD20 antibodies and fusion proteins thereof and methods of use
PharmCast:  Oct 31 2008 12:49PM Matching: muc1
Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy
MDLinx:  Oct 29 2008 10:56AM Matching: muc1
Study: Minerva Biotechnologies' MUC1* discovery could lead to non-fibroblast stem cell growth method
Drug Discovery News:  Oct 22 2008 8:28AM Matching: muc1
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Study of the MUC1 Peptide-Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma
Risk for Colorectal Cancer

Patents:

Patents logo
US Patent No.Title
7348420 Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
7364727 Metastatic colon cancer specific promoter and uses thereof
7368548 Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer
7371207 Estrogen receptor .alpha. regulated gene expression, related assays and therapeutics
7371572 Mouse titers after two immunizations with VLPs alone

View more patents.

MUC1 results (if any) from reagent suppliers

Google CSE Logo
MUC1 antibodies | Abcam
MUC1 antibodies. ... MUC1 antibody [LBS-1]. ICC/IF, IHC-Fr. Mouse monoclonal ... MUC1 antibody [PR 4D1]. IHC-FoFr. Mouse monoclonal ...
http://www.abcam.com/index.html?t=53037&pt=1&c=751...

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Muc1.
29 Apr 2003 ... Muc1 is a heavily O-glycosylated transmembrane protein ... cancer Muc1 is overexpressed; is underglycosylated and the ...
http://www.exalpha.com/pdfs/X1602M.pdf...

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MUC1 antibody [M9E7] (ab8322) datasheet | Abcam
Mouse monoclonal [M9E7] to MUC1. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some ...
http://www.abcam.com/MUC1-antibody-M9E7-ab8322.html...

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GTX28323-MUC1 antibody [M2C5]-GeneTex Inc.
MUC1 antibody [M2C5] 4M40-M2C5 GTX28323 GTX28323 Mouse monoclonal [M2C5] to MUC1 CA 15-3 CA15-3 MAM6 M2C5 4582 | MUC1 | 158340 | P15941 | CD227 | EMA ...
http://www.genetex.com/commerce/catalog/product.jsp?product_...

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MUC1 antibody, MUC1 [X19] antibody Antibody, Mouse IgG Monoclonal ...
Buy quality mouse MUC1 antibody (interacts with human), anti-MUC1, MUC1 [X19] antibody antibody, ... Mouse monoclonal [X19] to MUC1, N/A. [ N/AN/AN/A ].
http://www.genwaybio.com/product_info.php?products_id=190085...

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GTX10118-MUC1 antibody [M2F1]-GeneTex Inc.
MUC1 antibody [M2F1] 4M40-M2F1 GTX10118 10118 GTX10118 M2F1 MUC1 MUC1 M2F1 M2F1 MUC1 ab10118 M2F1 MUC1 MUC1 M2F1 M2F1 MUC1 Breast carcinoma associated ...
http://www.genetex.com/commerce/catalog/product.jsp?product_...

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Eurogentec - Research - MUC-1 Monoclonal Antibody, Purified (SIGNET)
Purified Monoclonal Antibody against MUC-1 (BC2), (Formerly Signet Catalog No: 621-01)
http://www.eurogentec.com/product/research-muc-1-monoclonal-...

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GTX10119-MUC1 antibody [M3A106]-GeneTex Inc.
MUC1 antibody [M3A106] 4M40-M3A106 GTX10119 10119 GTX10119 M3A106 MUC1 MUC1 M3A106 M3A106 MUC1 M3A106 MUC1 MUC1 M3A106 M3A106 MUC1 Breast carcinoma ...
http://www.genetex.com/commerce/catalog/product.jsp?product_...

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Muc1 antibody, Muc1 Antibody, Mouse IgG Monoclonal Antibody
Buy quality mouse Muc1 antibody (interacts with n/a), anti-Muc1, Muc1 antibody, mouse igg monoclonal antibody, Muc1 Antibody, Mouse IgG Monoclonal Antibody ...
https://www.genwaybio.com/product_info.php?products_id=24010...

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MUC1 antibody, Mucin-1 Antibody, Chicken IgY Polyclonal Antibody
Buy quality chicken MUC1 antibody (interacts with human mouse rat), anti-MUC1, Mucin-1 antibody, chicken igy polyclonal antibody, Mucin-1 Antibody, ...
http://www.genwaybio.com/product_info.php?products_id=600...

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