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MUC1


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Symbol:MUC1
Name(s):mucin 1, cell surface associated
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD227, EMA, H23AG, MAM6, PEM, PEMT, PUM
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18161663 CA 15-3 levels might have a role in the response to EGFR inhibitors in patients with bronchioloalveolar carcinoma
18268124 Observational study of gene-disease association. (HuGE Navigator)
17916995 A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human papillary thyroid carcinoma and papillary microcarcinoma
18037881 MUC1 is important for physiological activation of IKKbeta and that overexpression of MUC1, as found in human cancers, confers sustained induction of the IKKbeta-NF-kappaB p65 pathway.
11062147 Observational study of gene-disease association. (HuGE Navigator)
11464247 Observational study of gene-disease association. (HuGE Navigator)
12105832 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
12734543 Observational study of gene-disease association. (HuGE Navigator)
15944787 Observational study of gene-disease association. (HuGE Navigator)
16357367 Observational study of gene-disease association and genetic testing. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHuman bax gene, 5' region.mucin 1, transmembraneMUC1 C-ter interacts with the Bax promoter.-Pubmed
BINDHuman p21 gene, partial promoter sequence.mucin 1, transmembraneMUC1 C-ter interacts with the p21 promoter.-Pubmed
BINDcatenin, beta 1, 88kDamucin 1, transmembraneMUC1 interacts with beta-catenin.-Pubmed
HPRDcatenin, beta 1, 88kDaMucin-1 precursor (Breast carcinoma...--Pubmed
HPRDcatenin, beta 1, 88kDaMucin-1 precursor (Breast carcinoma...--Pubmed
HPRDcatenin, delta 1 isoform 1BMucin-1 precursor (Breast carcinoma...--Pubmed
HPRDepidermal growth factor receptor oncogene homolog, avian)Mucin-1 precursor (Breast carcinoma...--Pubmed
HPRDepidermal growth factor receptor oncogene homolog, avian)Mucin-1 precursor (Breast carcinoma...--Pubmed
BINDepidermal growth factor receptor isoform amucin 1, transmembraneMUC1 interacts with and is tyrosine-phosphorylated by EGFR.-Pubmed
HPRDv-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homologMucin-1 precursor (Breast carcinoma...--Pubmed

Recent Publications on MUC1:

Pubmed Logo
A Novel Bacillus Calmette-Guerin-based Breast Cancer Vaccine that Coexpresses Multiple Tandem Repeats of MUC1 and CD80 Breaks the Immune Tolerance and Inhibits MUC1-Positive Breast Cancer Growth.
Abstract Many approaches targeting MUC1 for breast tumor immunotherapy...
3rd November, 2009
1 Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Cancer Biother Radiopharm. 2009 Oct;24(5):607-13.
DOI Direct Link
Tumor burden influences cytotoxic T cell development in metastatic breast cancer patients--a phase I/II study.
The influence of tumor burden on the generation of tumor antigen-specific...
29th October, 2009
Medical Service, Amarillo Veterans Affairs Health Care System, Amarillo, Immunol Invest. 2009;38(8):820-38.
Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology.
Malignant ascites may be the first presentation of an unsuspected cancer....
27th October, 2009
Department of Pathology, Wayne State University and Karmanos Cancer Diagn Cytopathol. 2009 Oct 23.
DOI Direct Link
Functional Neoglycopeptides: Synthesis and Characterization of a New Class of MUC1 Glycoprotein Models Having Core 2-Based O-Glycan and Complex-Type N-Glycan Chains.
An efficient protocol for the construction of MUC1-related glycopeptide...
27th October, 2009
Division of Advanced Chemical Biology, Graduate School of Life Science, Biochemistry. 2009 Oct 30.
DOI Direct Link
Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis.
Spontaneous immune responses in cancer patients have been described. Yet...
22nd October, 2009
Department of Obstetrics and Gynecology, University Hospital of Cancer Res. 2009 Nov 1;69(21):8420-8. Epub 2009 Oct 20.
DOI Direct Link

View more research publications.

Press Releases on MUC1:

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Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 30th September, 2009 Quest PharmaTech Inc.

TSX Venture: QPT

EDMONTON, Sept. 30 /PRNewswire-FirstCall/ - Quest PharmaTech Inc. (TSX-V: QPT) ("Quest" or the "Company"), a pharmaceutical company developing

Oncothyreon announces initiation of Phase 3 trial of Stimuvax in breast cancer 22nd June, 2009 Oncothyreon Inc.

SEATTLE, June 22 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY) (TSX:ONY) (the "Company") today announced that Merck KGaA of Darmstadt, Germany, has initiated a global Phase 3

Merck KGaA acquires manufacturing rights for Stimuvax from Oncothyreon 18th December, 2008 Oncothyreon Inc.

SEATTLE, Dec. 18 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY) (TSX:ONY) announced today that Merck KGaA of Darmstadt, Germany has licensed the right to manufacture Stimuvax(R) and,

Oncothyreon announces prioritization plan for development programs 2nd September, 2008 Oncothyreon Inc.

SEATTLE, Sept. 2 /PRNewswire-FirstCall/ - Oncothyreon Inc. (NASDAQ: ONTY) (TSX: ONY) (the "Company") today announced a prioritization plan to focus the Company's resources on the

Stimuvax Phase 1/2 survival data support prior results 2nd June, 2008 Oncothyreon Inc.

BELLEVUE, WA, June 2 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY) (TSX: ONY) today announced the presentation of two-year survival data from a Phase 1/2 multicenter study of

BioNews Results for MUC1

: RSS Logo
BioPortfolio Logo
Evaluation Of Ocular Surface Disorders: A New Diagnostic Tool Based On Impression Cytology And Confocal Laser Scanning Microscopy
British Journal of Ophthalmology:  Oct 14 2009 11:29PM Matching: muc1
MUC1 protein defends against the stomach ulcer bacterium, according to study
News-Medical.Net:  Oct 14 2009 10:48AM Matching: muc1
Research team identifies a protein that defend against stomach ulcer bacterium
News-Medical.Net:  Oct 14 2009 5:00AM Matching: muc1
Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer
MDLinx:  Oct 13 2009 9:51AM Matching: muc1
Sahlgrenska researchers identify special protein that defends against stomach ulcer bacterium
News-Medical.Net:  Oct 12 2009 9:45AM Matching: muc1
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Study of the MUC1 Peptide-Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma

Patents:

Patents logo
US Patent No.Title
7531300 Method of diagnosing breast cancer
7547759 Induction of tumor immunity by variants of folate binding protein
7550143 Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
7550146 Glycopeptide conjugates and uses thereof
7550148 Targeting of Herpes simplex virus to specific receptors

View more patents.

MUC1 results (if any) from reagent suppliers

Google CSE Logo
The Abcam catalog
MUC1 antibodies. ... MUC1 antibody [LBS-1]. ICC/IF, IHC-Fr. Mouse monoclonal. Reacts with: Hu. ab20158 · MUC1 antibody [PR 4D1]. IHC-FoFr. Mouse monoclonal
...
http://www.abcam.com/index.html?t=53037&pt=1&c=751...

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Anti-MUC1 Polyclonal Antibody
Polyclonal Antibody against MUC1 for use in Immunohistochemistry, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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MUC1 antibody [M9E7] (ab8322) | Abcam
Mouse monoclonal [M9E7] to MUC1. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some ...
http://www.abcam.com/MUC1-antibody-M9E7-ab8322.html...

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MUC1 antibody, Mucin-1 Antibody, Chicken IgY Polyclonal Antibody
Buy quality chicken MUC1 antibody (interacts with human mouse rat), anti-MUC1, Mucin-1 antibody, chicken igy polyclonal antibody, Mucin-1 Antibody, ...
http://www.genwaybio.com/product_info.php?products_id=600...

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Anti-MUC1 Monoclonal Antibody
Monoclonal Antibody against MUC1 for use in ELISA, Immunohistochemistry ( Paraffin, Frozen)
http://www.bioreagents.com/products/productDetails/productDe...

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MUC1 Antibody Anti-MUC1
MUC1 antibody can be used for Western blot at a suggested dilution at 0.5µg/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be ...
http://www.prosci-inc.com/shop/catalog1/MUC1-Antibody-p-1017...

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Anti-MUC1 Polyclonal Antibody
Polyclonal Antibody against MUC1 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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