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MUTYH

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Symbol:	MUTYH
Name(s):	mutY homolog (E. coli)
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	MGC4416, MYH
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18027849	investigate the possible role of germline hypermethylation of the APC promoter in FAP and AFAP families that were negative for APC and MUTYH mutations
18271935	Observational study of gene-disease association. (HuGE Navigator)
18294051	Observational study of genotype prevalence. (HuGE Navigator)
18301448	Observational study of gene-disease association. (HuGE Navigator)
18172263	KRAS2 c.34G > T somatic prescreening, followed by MUTYH hotspot mutation analysis when positive, can identify patients with (atypical) MUTYH-associated polyposis
18186383	study reports a case of siblings with identical germline mutations in the MYH gene, one of whom developed a locally advanced colon adenocarcinoma with few other adenomatous lesions, whereas the other had numerous benign colonic polyps
18155253	Observational study of gene-disease association. (HuGE Navigator)
18172263	Observational study of genotype prevalence. (HuGE Navigator)
14999774	Observational study of gene-disease association. (HuGE Navigator)
15236166	Observational study of gene-disease association and genetic testing. (HuGE Navigator)
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	Apex nuclease	mutY homolog isoform 1	-	-	Pubmed
BIND	APEX nuclease	MutY homolog	hMYH is associated in vivo with apurinic/apyrimidinic endonuclease (APE1)	-	Pubmed
HPRD	APEX nuclease	MYH	-	-	Pubmed
BIND	mutS homolog 6	mutY homolog isoform 1	hMYH interacts with hMSH6.	-	Pubmed
HPRD	MYH	replication protein A1, 70kDa	-	-	Pubmed
BIND	MutY homolog	proliferating cell nuclear antigen	hMYH is associated in vivo with proliferating cell nuclear antigen (PCNA)	-	Pubmed
BIND	MutY homolog	replication protein A1, 70kDa	hMYH is associated in vivo with replication protein A (RPA)	-	Pubmed
HPRD	mutY homolog isoform 1	Proliferating cell nuclear antigen	-	-	Pubmed
HPRD	mutY homolog isoform 1	RPA1	-	-	Pubmed

Recent Publications on MUTYH:
Idiopathic gastric acid hypersecretion in a patient with MUTYH-associated polyposis. Reactive oxygen species (ROS) interact with DNA, frequently generating...	30th October, 2009		Am J Gastroenterol. 2009 Oct;104(10):2648-9. DOI Direct Link
Deep sequencing to reveal new variants in pooled DNA samples. We evaluated massive parallel sequencing and long-range PCR (LRP) for rare...	21st October, 2009	Department of Clinical Genetics, Leiden University Medical Center, Leiden,	Hum Mutat. 2009 Sep 4. DOI Direct Link
Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer. MUTYH-associated polyposis (MAP) is the only inherited colorectal cancer...	20th October, 2009	Department of Chemistry, University of California Davis, One Shields	DNA Repair (Amst). 2009 Oct 14. DOI Direct Link
Familial adenomatous polyposis. ABSTRACT: Familial adenomatous polyposis (FAP) is characterized by the...	14th October, 2009		Orphanet J Rare Dis. 2009 Oct 12;4(1):22. DOI Direct Link
An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda. Reactive oxygen species (ROS) interact with DNA, frequently generating...	13th October, 2009	Institute of Veterinary Biochemistry and Molecular Biology, University of	Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18201-6. Epub 2009 Oct 9. DOI Direct Link
→View more research publications.

Patents:
US Patent No.	Title
7291461	Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay
7235358	Methods and compositions for diagnosing and monitoring transplant rejection
7026121	Methods and compositions for diagnosing and monitoring transplant rejection
6905827	Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

MUTYH results (if any) from reagent suppliers

MUTYH (A-13) Antibody sc-30631 MUTYH shRNA (m) Lentiviral Particles, sc-45816-V, 200 µl ... Western blot analysis of MUTYH expression in non-transfected: sc-117752 (A) and mouse MUTYH ... http://www.scbt.com/datasheet-30631-mutyh-a-13-antibody.html...
NEIL1 antibody, NEIL1 Antibody, Goat Polyclonal Antibody Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3 [4] Hatt,L., Loft,S., ... http://www.genwaybio.com/product_info.php?products_id=336098...
MUTYH (LB-9) Antibody sc-101238 MUTYH shRNA (h) Lentiviral Particles, sc-37407-V, 200 µl ... MUTYH (LB-9): sc- 101238. Western blot analysis of MUTYH expression in HeLa nuclear extract. ... http://www.scbt.com/datasheet-101238-mutyh-lb-9-antibody.htm...
Abgent - Cancer Antibodies - Cancer AT2939aNEW, MUTYH monoclonal antibody (M01), ELISA,RNAi-Ab,S-ELISA,WB-Ce,WB-Re, H. AP6717aNEW, MVD Antibody (N-term), WB, E, H ... http://www.abgent.com/products/category/cell_function/cancer...
MUTYH Antibody / MUTYH Antibodies MUTYH Antibody / MUTYH Antibodies. ... MUTYH spezifische siRNA, sHRNA Plasmide und shRNA Lentivirale Partikel Gen Silencer sind ebenfalls erhältlich. ... http://www.scbt.com/de/table-mutyh.html...
ATCC:Publications for 2004 ... Nakabeppu Y. Identification and characterization of two forms of mouse MUTYH protein encoded by alternatively spliced transcripts Nucleic Acids Res. ... http://www.atcc.org/LinkClick.aspx?link=829&tabid=688...
MUTYH (M-15) Antibody sc-30633 MUTYH shRNA (m) Lentiviral Particles, sc-45816-V, 200 µl ... MUTYH (M-15): sc- 30633. Western blot analysis of MUTYH expression in HeLa nuclear extract. ... http://www.scbt.com/datasheet-30633-MUTYH-m-15-antibody.html...

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MUTYH

Gene Information from Publications

Interacting gene products

Recent Publications on MUTYH:

Patents:

MUTYH results (if any) from reagent suppliers