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MYC


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Symbol:MYC
Name(s):v-myc myelocytomatosis viral oncogene homolog (avian)
Type:protein-coding
Organism:Homo sapiens
Synonyms:c-Myc
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18206534 The established renal cell carcinoma consist of two cell populations, one containing four and one containing five copies of the MYC oncogene.
18206725 Downregulation of c-Myc is critical for 2ME2-induced oxidative stress and apoptosis in AML cells.
18242516 By misdirecting the activity of Activation-Induced Deaminase (AID) to a conditional MYC transgene, sporadic, AID-dependent MYC activation in germinal center B cells of Vk*MYC mice, is achieved.
17881732 ZO-2 down-regulates cyclin D1 transcription by interacting with the c-Myc/E box element and by recruiting histone deacetylase 1
18085637 Id2 commonly is overexpressed in highly proliferative T-cell lymphomas, and its expression may result from transcriptional activation of myc in these tumors.
17573914 C-myc gene had the same location chromosome 8 in pluripotent and in differentiated human embryonic stem cells
17704800 A truncated form of N-Myc wild type can fully rescue the proliferation defect in myc-null fibroblasts, but rescue is dependent on the highly conserved Myc homology box II.
18190704 variation at putative 8q24 cis-regulator(s) of transcription can significantly alter germline c-MYC expression levels and, thus, contribute to prostate cancer susceptibility by down-regulating the prostate tumor suppressor KLF6 gene.
15929079 Observational study of gene-disease association. (HuGE Navigator)
15991278 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDactin-like 6A isoform 1v-myc myelocytomatosis viral oncogene homolog--Pubmed
HPRDactin-like 6A isoform 1v-myc myelocytomatosis viral oncogene homolog--Pubmed
HPRDbreast cancer 1, early onset isoform 1v-myc myelocytomatosis viral oncogene homolog--Pubmed
HPRDbreast cancer 1, early onset isoform 1v-myc myelocytomatosis viral oncogene homolog--Pubmed
BINDbreast cancer 1, early onset isoform 1v-myc myelocytomatosis viral oncogene homologBRCA1 association with c-Myc, a proto-oncogene that is implicated in tumorigenesis, embryonic development and apoptosis, inhibits its transcriptional and transforming activity in cells.-Pubmed
HPRDcyclin T1v-myc myelocytomatosis viral oncogene homolog--Pubmed
HPRDcyclin T1v-myc myelocytomatosis viral oncogene homolog--Pubmed
HPRDcell division cycle 6 proteinv-myc myelocytomatosis viral oncogene homolog--Pubmed
HPRDcell division cycle 6 proteinv-myc myelocytomatosis viral oncogene homolog--Pubmed
BINDHomo sapiens chromosome 12v-myc myelocytomatosis viral oncogene homologMYC (c-Myc) interacts with CDK4 promoter.-Pubmed

Recent Publications on MYC:

Pubmed Logo
Signal transduction of the melatonin receptor MT1 is disrupted in breast cancer cells by electromagnetic fields.
The growth of estrogen-receptor positive breast cancer cells is inhibited...
3rd November, 2009
Department of Gynecology and Obstetrics, University of Gottingen, Bioelectromagnetics. 2009 Oct 30.
DOI Direct Link
BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.
Expression profiling of BRCA1-deficient tumours has identified a pattern...
3rd November, 2009
Department of Oncology, Centre for Cancer Research and Cell Biology, Breast Cancer Res Treat. 2009 Oct 31.
DOI Direct Link
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.
Several decades of research have sought to characterize tumor cell...
3rd November, 2009
[1] Department of Pediatrics, University of Texas Southwestern Medical Oncogene. 2009 Nov 2.
DOI Direct Link
Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.
Although Wnt signaling activation is frequently observed in human breast...
3rd November, 2009
Department of Pediatrics, Washington University School of Medicine, St Oncogene. 2009 Nov 2.
DOI Direct Link
c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma.
The germinal center (GC) reaction has a pivotal function in human B-cell...
3rd November, 2009
Institute of Clinical Molecular Biology, Helmholtz Center Munich, German Oncogene. 2009 Nov 2.
DOI Direct Link

View more research publications.

Press Releases on MYC:

BioPortfolio Logo
Clarient Launches New Breast Cancer Test 5th May, 2009 Clarient, Inc.

The Clarient Insight(R) Dx Breast Cancer Profile Assists Physicians In Identifying Recurrence Risk and the Need for Chemotherapy

ALISO VIEJO, Calif., May 5 /PRNewswire

The Leukemia & Lymphoma Society Honors Five Scientists for Outstanding Work in Blood Cancer Research 4th August, 2008 The Leukemia & Lymphoma Society

WHITE PLAINS, N.Y., Aug. 4 /PRNewswire/ -- The Leukemia & Lymphoma Society (LLS) has named five researchers as Stohlman Scholars, recognizing their outstanding contributions to the

BioNews Results for MYC

: RSS Logo
BioPortfolio Logo
Avalon Pharmaceuticals, Inc. - Financial And Strategic Analysis Review - New Report Published
OfficialSpin:  Nov 14 2009 9:12AM Matching: myc
Aileron Therapeutics Collaborators Publish In Vivo Research in Nature Showing Stapled Peptides Achieve the Fir
Pharma Live:  Nov 14 2009 12:33AM Matching: myc
Stapled Peptides directly inhibit the Notch transcription factor complex
News-Medical.Net:  Nov 12 2009 9:18AM Matching: myc
Stapled Peptides can inhibit key intracellular biological targets, says new research
News-Medical.Net:  Nov 12 2009 9:10AM Matching: myc
Aileron Therapeutics Collaborators Publish In Vivo Research in Nature Showing Stapled Peptides Achieve the First Direct Inhibition of the Notch1 Trans
Yahoo! Canada:  Nov 11 2009 8:15PM Matching: myc
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Studying Tissue Samples From Women With Breast Cancer Who Were Treated on Clinical Trial NCCTG-N9831

Patents:

Patents logo
US Patent No.Title
7608423 Expanding the eukaryotic genetic code
7611700 Protease resistant modified interferon alpha polypeptides
7611703 Kidney disease targets and uses thereof
7611711 VEGFR-3 inhibitor materials and methods
7611713 Inducing cellular immune responses to hepatitis B virus using peptide compositions

View more patents.

MYC results (if any) from reagent suppliers

Google CSE Logo
Myc tag antibody (ab9106) reviews | Abcam
Rabbit polyclonal to Myc tag. Epitope tags are short peptide sequences that are easily recognized by tag-specific antibodies. Due to their small size, ...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=9...

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M4439 Monoclonal Anti-c-Myc antibody produced in mouse clone 9E10 ...
M4439 Monoclonal Anti-c-Myc antibody produced in mouse clone 9E10, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=M443...

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c-Myc antibody (ab11917) | Abcam
Rabbit polyclonal to c-Myc. The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly ...
http://www.abcam.com/c-Myc-antibody-ab11917.html...

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N-Myc Antibody #9405
Western blot analysis of extracts from HeLa cells either mock transfected or transfected with murine N-Myc, using N-Myc Antibody. ...
http://www.cellsignal.com/products/9405.html...

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c-Myc Antibody / c-Myc Antibodies
c-Myc Antibody / c-Myc Antibodies. ... c-Myc specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-c-myc.html...

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MYC Antibody
Specific antibody for the gene product of MYC, the protein c-Myc. Validated for specificity by gene-silencing with siRNA followed by Western blot detection ...
http://www.piercenet.com/Products/browse.cfm?fldID=BAB2D9BC-...

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c-Myc (9E10) Monoclonal Antibody sc-40
See how others have used c-Myc (9E10): sc-40 antibody and or c-Myc (9E10) ... Western blot analysis of c-Myc expression in non-transfected: sc-110760 (A) ...
http://www.scbt.com/datasheet-40-c-myc-9e10-antibody.html...

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