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GADD45B
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17485467 |
Association of Gadd45beta with MKK7 involves a network of interactions mediated by its putative helices alpha3 and alpha4 and loops 1 and 2 |
| 14630914 |
SMAD3 and SMAD4 activate gadd45beta through its third intron to facilitate G2 progression following TGFbeta treatment |
| 12162804 |
participation of NF-kappaB in the regulation of Gadd45beta |
| 15509538 |
methylation might play a crucial role in the epigenetic regulation of GADD45beta in hepatocyte transformation that may be directed by p53 status |
| 15546867 |
TGF-beta induces biglycan expression through ALK5 and GADD45beta |
| 17437852 |
We found significant differences in gene expression, specifically with a group of genes, including GADD45beta, known to be responsive to estrogen or to interact with estrogen receptor. |
| 17591973 |
our results suggest that GADD45beta induction by SAMe via NF-kappaB may represent a novel mechanism of SAMe-mediated hepatoprotection, with p53 playing an important role. |
| 12759252 |
Results suggest that GADD45beta, which is down-regulated in most cases of hepatocellular carcinoma (HCC), remains an ideal candidate for development as a molecular marker in the diagnosis of HCC and as a potential therapeutic target. |
| 12855571 |
in B cells, Gadd45 beta is induced by CD40 through a mechanism that requires NF-kappa B and that induction suppresses Fas-mediated killing |
| 16144844 |
GADD45beta plays an essential role during chondrocyte terminal differentiation and mediates MMP-13 gene expression | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Cyclin B1 | growth arrest and DNA-damage-inducible, beta | - | - | Pubmed |
| BIND | - | growth arrest and DNA-damage-inducible, beta | Cyclin B1 interacts with Gadd45b. This interaction was modeled on a demonstrated interaction between human Cyclin B1 and Gadd45b from an unspecified species. | - | Pubmed |
| HPRD | cyclin B1 | GADD45 beta | - | - | Pubmed |
| BIND | - | growth arrest and DNA-damage-inducible, beta | Cdk1 interacts with Gadd45b. This interaction was modeled on a demonstrated interaction between human Cdk1 and Gadd45b from an unspecified species. | - | Pubmed |
| HPRD | cell division cycle 2 protein isoform 1 | growth arrest and DNA-damage-inducible, beta | - | - | Pubmed |
| HPRD | cell division cycle 2 protein isoform 1 | growth arrest and DNA-damage-inducible, beta | - | - | Pubmed |
| HPRD | Cyclin dependent kinase inhibitor 1A | growth arrest and DNA-damage-inducible, beta | - | - | Pubmed |
| HPRD | cyclin-dependent kinase inhibitor 1A | GADD45 beta | - | - | Pubmed |
| HPRD | growth arrest and DNA-damage-inducible, alpha | growth arrest and DNA-damage-inducible, beta | - | - | Pubmed |
| HPRD | growth arrest and DNA-damage-inducible, alpha | growth arrest and DNA-damage-inducible, beta | - | - | Pubmed |
Recent Publications on GADD45B: |  |
Age-associated changes in cardiac gene expression after preconditioning.
BACKGROUND: Cardiac protection afforded by ischemic preconditioning (IPC)... | 28th October, 2009
| Department of Anesthesiology, Stony Brook University School of Medicine,
| Anesthesiology. 2009 Nov;111(5):1052-64.
DOI Direct Link |
Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli.
The GADD45 family of proteins consists of three small proteins, GADD45A,... | 17th October, 2009
| Fels Institute for Cancer Research and Molecular Biology, Temple
| J Cell Biochem. 2009 Oct 15.
DOI Direct Link |
Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells.
BACKGROUND: The precise mechanism of the anti-tumor action of fucoxanthin... | 18th September, 2009
| Department of Biochemistry and Molecular Biology, Graduate School of
| Biochim Biophys Acta. 2009 Apr;1790(4):260-6.
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The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
Our overall goal is to elucidate progressive changes, in expression and... | 18th September, 2009
| Department of Biochemistry and Molecular Biology, Michigan State
| Toxicol Sci. 2009 Aug;110(2):319-33. Epub 2009 May 29.
DOI Direct Link |
Gadd45b and Gadd45g are important for anti-tumor immune responses.
An effective Th1 type cell-mediated immune response against cancer cells... | 19th August, 2009
| Department of Immunology, University of Pittsburgh School of Medicine,
| Eur J Immunol. 2009 Aug 17;39(11):3010-3018.
DOI Direct Link |
→View more research publications. |
GADD45B results (if any) from reagent suppliers | 
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GADD45B protein (Human) (ab79246) | Abcam
GADD45B protein (Human). Expression of GADD45B is increased following treatment with DNA damage agents or other stressful growth arrest conditions.
http://www.abcam.com/GADD45B-protein-Human-ab79246.html...
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GADD 45β (N-19) Antibody sc-8775
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GADD45B, 4616, 19p13.3, NM_015675 ...
http://www.scbt.com/datasheet-8775-gadd-45beta-n-19-antibody...
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GADD45B proteins and peptides: Immunology > Immune System Diseases ...
GADD45B proteins and peptides. ... Applications (see key) & Reactivity (see key) . Image Abreview Publication. ab79246 · GADD45B protein (Human). SDS-PAGE ...
http://www.abcam.com/index.html?t=242370&pt=2&c=2241&ei=&mu=...
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GADD Antibody / GADD Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. GADD 34 (C-19) Antibody, sc-825, rabbit IgG, C-terminus (m), WB, IP, IF, ELISA, m, r ...
http://www.scbt.com/ko/table-gadd.html...
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Cell Biology: primary antibodies, proteins, peptides, kits | Abcam
... FOXO1 + FOXO3 + FOXO4 antibodies (2) · GADD45B proteins and peptides (1) · GADD45G antibodies (2) · GADD45G proteins and peptides (2) · GAS2 antibodies ...
http://www.abcam.com/index.html?cl=246&pageconfig=productmap...
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GADD Antibody / GADD Antibodies
製品名, カタログ番号, アイソタイプ, エピトープ, アプリケーション, 動物種. GADD 34 (C-19) 抗体, sc-825, rabbit IgG, C-terminus (m), WB, IP, IF, ELISA, m, r ...
http://www.scbt.com/ja/table-gadd.html...
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