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SERPINC1
| Symbol: | SERPINC1 | | Name(s): | serpin peptidase inhibitor, clade C (antithrombin), member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AT3, ATIII, MGC22579 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17244682 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18056677 |
High antithrombin III in cerebrospinal fluid is associated with CNS lymphoma |
| 17849067 |
Report novel antithrombin heparin-binding site variant associated with low thrombotic risk. |
| 17492649 |
findings suggested that FS-3Stop and Met-32Thr mutations are responsible for type I antithrombin deficiency, whereas Ser116Pro and Ala59Val mutations contribute to type II antithrombin deficiency |
| 17597998 |
REVIEW OF AT3 BINDING INTERACTIONS, HEREDITARY AT3 DEFICIENCY, LOW LEVEL IN DIC |
| 11754060 |
The karyotype showed 46XY, del(1)(q23q31.2), the antithrombin III (AT3, 1q23-q25.1) serum level and activity were half of normal. |
| 16940049 |
tyrosine 131 in the native conformation of antithrombin III activates it for factor Xa inhibition |
| 11861278 |
Antithrombin prevents endotoxin-induced hypotension by inhibiting the induction of nitric oxide synthase in rat lung. |
| 12466122 |
Data show that anti-thrombin is widely expressed in prostate cancer but is gradually lost in tumors of high Gleason grade. |
| 15733967 |
The two mutated antithrombins were the same as that of wild type, but the specific activity of the E381del mutant decreased significantly compared with that of wild type. | →View more information from publications. |
Recent Publications on SERPINC1: |  |
Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis.
INTRODUCTION: Genetic deficiencies of PROS1, PROC, and SERPINC1... | 23rd October, 2009
| National Cardiovascular Center Research Institute, Suita, Osaka, Japan.
| Thromb Res. 2009 May;124(1):14-8. Epub 2008 Oct 26.
DOI Direct Link |
Detection and characterisation of large SERPINC1 deletions in type I inherited antithrombin deficiency.
Methods routinely used for investigating the molecular basis of... | 18th September, 2009
| Service d'Hematologie Biologique, AP-HP, Hopital Europeen Georges
| Hum Genet. 2009 Sep 17.
DOI Direct Link |
Functional consequences of the prothrombotic SERPINC1 rs2227589 polymorphism on antithrombin levels.
Genetic factors involved in the interindividual variability of... | 6th August, 2009
| Centro Regional de Hemodonacion. C/ Ronda de Garay s/n. Murcia 30003.
| Haematologica. 2009 Apr;94(4):589-92. Epub 2009 Feb 19.
DOI Direct Link |
Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.
Sex differences in thrombosis are well described, but their underlying... | 26th September, 2008
| Cardiovascular Research Institute, Department of Medicine, Division of
| J Clin Invest. 2008 Aug;118(8):2969-78.
DOI Direct Link |
Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats.
The Dahl salt-sensitive (SS) rat is a widely used model of human... | 18th July, 2008
| Department of Physiology, Medical College of Wisconsin, Milwaukee,
| Physiol Genomics. 2008 Jun 12;34(1):54-64. Epub 2008 Apr 22.
DOI Direct Link |
→View more research publications. |
SERPINC1 results (if any) from reagent suppliers | 
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SERPINC1 Antibody (C-term)
Western blot analysis of SERPINC1 Antibody (C-term) (Cat. #AP6715b) in mouse liver tissue lysates (35ug/lane). SERPINC1 (arrow) was detected using the ...
http://www.abgent.com/products/catalog_no/AP6715b...
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Antibodies to Proteins of Inflammation
human ... SERPINC1(462), human, DB, ELISA (i), WB, pricing. C1688, Monoclonal Anti-C-Reactive Protein antibody produced in mouse, CRP-8 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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Abgent Antibodies and Peptides
AP6737b, Lamin B2 Antibody (C-term), WB, E, H, 2009-10-29. AP6715b, SERPINC1 Antibody (C-term), WB, E, H, M, 2009-10-29 ...
http://www.abgent.com/products/new_release...
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Antibodies to Human Plasma Proteins
ascites fluid, human ... SERPINC1(462), human, DB, ELISA (i), WB, pricing. B9277 , Monoclonal Anti-Band 3 antibody produced in mouse, BIII-136 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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ATIII (4B3) Antibody sc-80618
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SERPINC1, 462, 1q25.1, NM_000488 ...
http://www.scbt.com/datasheet-80618-atiii-4b3-antibody.html...
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A5816 Monoclonal Anti-Antithrombin III antibody produced in mouse ...
immunoblotting: 1:200 using human antithrombin III. indirect ELISA: suitable. isotype, IgG1. Gene Information, human ... SERPINC1(462). shipped in, dry ice
...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=ja...
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Abgent - Metabolism Antibodies - Metabolism
AP2787cNEW, SEPHS1 Antibody (Center), IHC, E, H. AP6714bNEW, SERPINA7 Antibody ( C-term), WB, E, H. AP6715bNEW, SERPINC1 Antibody (C-term), WB, E, H, M ...
http://www.abgent.com/products/category/cell_function/metabo...
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